DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Picot and MFS10

DIOPT Version :9

Sequence 1:	NP_725600.1	Gene:	Picot / 36865	FlyBaseID:	FBgn0024315	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001285188.1	Gene:	MFS10 / 32263	FlyBaseID:	FBgn0030452	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	211/518 - (40%)
Similarity:	293/518 - (56%)	Gaps:	59/518 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 TRYFVTFMLFLGMANAYVMRTNMSVAIVAMVNHTAIKSGEAEEYD-DECGDRDIPI--------D 94
            ||:...||.|||.|..|.||.|:|||||||||.|||....:...| |.|   .:|.        :
  Fly    67 TRHIFGFMGFLGFAVVYAMRVNLSVAIVAMVNQTAIPHSNSSVIDTDTC---PLPAPHHNGSDPN 128

  Fly    95 DSQDGEFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARG 159
            ..::|||.|..|.||.:|.|||||||:||:|.|.:|:.||..:..|||:||.:||..:.|:||.
  Fly   129 PQKEGEFVWDEATQGLVLGSFFYGYVLTQVPGGRMAELYGGKKIYGYGVLITAVFTLITPLAAH- 192

  Fly   160 GGVWG---LCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLL 221
               |.   |..||.::|:|||...|..|||||.||||.||::..|.||||:..||:|||||:|.|
  Fly   193 ---WDLPLLVLVRILEGMGEGVTYPAMHAMLAHWIPPLERNKFAAIVYAGSNIGTVISMPLAGWL 254

  Fly   222 AEYGFDGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSHPTIDEREKKYINDSLW----------- 275
            ....|.|||||.||:||::|.:|.||::..|::.||.||.|.|.|::||..||.
  Fly   255 CSLDFLGGWPSAFYIFGLLGILWFIAWMYLVYDKPSDHPRISESEREYIERSLQVQRLINQDLAE 319

  Fly   276 -----GTDVV--KSP---PIPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLK 330
                 |.|.|  ::|   |||:.:::.|:|.:|||....|..:.:.|.:|||||||..:|.|.::
  Fly   320 AEEEEGQDEVSLRAPPEEPIPWSSLLTSVPLWAILLTQCGQGWAFYTQLTELPTYMSNILHFDIQ 384

  Fly   331 SNGLLSSLPYLAMWLFSMFISVVADWMISSKRFSHTATRKLINSIGQYGPGVALIAASYTGCDRA 395
            ||.||:::|||..|...:..|.:||||::.:..|...:.||.|::....|.:.||...|.||| .
  Fly   385 SNALLNAVPYLTSWFVGIACSALADWMLARRYISLLNSYKLWNTVASVVPSLGLIGIIYVGCD-W 448

  Fly   396 LTLAILTIGVGLNGG-IYSGFKINHLDLTPRFAGFLMSITNCSANLAGLLAPIAAGHLISDPSKP 459
            :.:..:..|||..|| :|:|.::||:.|:||:||.:..|||.:||:.|.|||...|.:|:  .:.
  Fly   449 VWVTFMLAGVGSFGGAVYAGNQMNHIALSPRYAGTMYGITNSAANICGFLAPYVIGLIIN--HRE 511

  Fly   460 MMGQWQIVFFIAAFVYIICGTFYNIFGSGERQYWDNPEDDEQKPALQTTVTTSPARLSNGSTA 522
            .:.||.:||::||.:.|.....|.||.|.|.|.|..               |.|.|.|....|
  Fly   512 TLTQWHLVFWLAAGLNIAGNFIYLIFASAEEQSWSK---------------TPPTRNSRSQRA 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Picot	NP_725600.1	2A0114euk	41..501	CDD:129972	204/493 (41%)
Picot	NP_725600.1	MFS	100..485	CDD:119392	171/409 (42%)
MFS10	NP_001285188.1	2A0114euk	63..547	CDD:129972	206/489 (42%)
MFS10	NP_001285188.1	MFS	134..538	CDD:119392	172/410 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	270	1.000	Domainoid score	I959
eggNOG	1	0.900	-	-		E1_KOG2532
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		mtm6607
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
	9	8.860