DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Picot and Slc17a4

DIOPT Version :9

Sequence 1:	NP_725600.1	Gene:	Picot / 36865	FlyBaseID:	FBgn0024315	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_795990.2	Gene:	Slc17a4 / 319848	MGIID:	2442850	Length:	492	Species:	Mus musculus

Alignment Length:	469	Identity:	156/469 - (33%)
Similarity:	250/469 - (53%)	Gaps:	12/469 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EQQPQRCFAT-RYFVTFMLFLGMANAYVMRTNMSVAIVAMVNHTAIKSG-EAEEYDDECGDRDI- 91
            ||..::.|.: |:.:.|:|.|...:.|..:.|:|.||.||||.|...|. .|.........:|:
Mouse    22 EQSFKKGFCSLRHGLAFILHLCNFSIYTQQMNLSFAITAMVNTTVASSQLNASTERPPTNSQDVW 86

  Fly    92 --PIDDSQDGEFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVP 154
              .:.:|:...:.|:..:||.:|||..||..|..||.|.:|..:|:...:|.|:||:||....:|
Mouse    87 NETLQESKAPVYDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIP 151

  Fly   155 VAARGGGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSG 219
            :|| ..||..|..:|.|||:.:..::...:::.|||.||.|||::.....:|:..||.:.:...|
Mouse   152 LAA-DAGVALLIVLRVIQGMAQVMVLTGQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGG 215

  Fly   220 LLAEYGFDGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSHPTIDEREKKYINDSLWGTDVVKSPP 284
            |:.:   ..|||.|||:||.:|....:.:...|::||.:||.|...|::||..||...|......
Mouse   216 LICQ---ALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGERRYITCSLAQEDCSLGWS 277

  Fly   285 IPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMF 349
            :|.||::||||.:||:.::....:...|:|...|||:..||:.:|:.:|:||:||::...:..:.
Mouse   278 LPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIIL 342

  Fly   350 ISVVADWMISSKRFSHTATRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSG 414
            ..::||:::|.|.......|||..::|.......|:...:....|:.|:|.|.:.........||
Mouse   343 GGLLADFLLSRKILRLVTIRKLFTAVGVLASSGILLPLPWVRSSRSTTMAFLVLSSVFASLCDSG 407

  Fly   415 FKINHLDLTPRFAGFLMSITNCSANLAGLLAPIAAGHLISDPSKPMMGQWQIVFFIAAFVYIICG 479
            ..||.||:.||:||||..:....:.|||.:||..||..||..|:  .| |:.|||:||.:.::..
Mouse   408 ALINFLDIAPRYAGFLKGLLQVFSYLAGGIAPTVAGFFISQDSE--FG-WRNVFFLAAAIDVVGL 469

  Fly   480 TFYNIFGSGERQYW 493
            .||.||...|.|.|
Mouse   470 LFYLIFSRAEVQDW 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Picot	NP_725600.1	2A0114euk	41..501	CDD:129972	152/457 (33%)
Picot	NP_725600.1	MFS	100..485	CDD:119392	130/384 (34%)
Slc17a4	NP_795990.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		2A0114euk	27..486	CDD:129972	154/464 (33%)
		MFS	98..475	CDD:119392	130/383 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838726
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5542
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.690