DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Picot and Slc17a8

DIOPT Version :9

Sequence 1:	NP_725600.1	Gene:	Picot / 36865	FlyBaseID:	FBgn0024315	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_714947.1	Gene:	Slc17a8 / 266767	RGDID:	628870	Length:	588	Species:	Rattus norvegicus

Alignment Length:	499	Identity:	167/499 - (33%)
Similarity:	268/499 - (53%)	Gaps:	39/499 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 RYFVTFMLFLGMANAYVMRTNMSVAIVAMVNHTAIKSGEAEEYDDECGDRDIPIDDSQDGEFAWS 104
            ||.:..|..||...::.:|.|:.||||.|||::.:       |.|  |..:|     |..:|.|.
  Rat    75 RYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTV-------YVD--GKPEI-----QTAQFNWD 125

  Fly   105 SALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARGGGVWGLCAVR 169
            ....|.|..|||:||::||||.|.::.|:.:.|..|..:.:.|.....:|.|||......:| ||
  Rat   126 PETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMC-VR 189

  Fly   170 FIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYGFDGGWPSIF 234
            .:|||.||...|..|.|.:||.||.||||:....:.|:..|.:::|||:|:|.:|   .||.|:|
  Rat   190 ILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQY---IGWASVF 251

  Fly   235 YVFGIVGTVWSIAFLIFVHEDPSSHPTIDEREKKYINDSLW-GTDVVKSPPI--PFKAIIKSLPF 296
            |::|:.|.:|.:.:|:..:|.|:.||||...|:.||..|:. |.::......  |::....|||.
  Rat   252 YIYGMFGIIWYMFWLLQAYECPAVHPTISNEERTYIETSIGEGANLASLSKFNTPWRRFFTSLPV 316

  Fly   297 YAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVADWMISSK 361
            |||:.|:...::.:..|:...|.|.::|..|::...||||::|::.|.:.......:||::.|.|
  Rat   317 YAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRK 381

  Fly   362 RFSHTATRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINHLDLTPRF 426
            ..:.||.||::| .|.:|....|:........:.:.::.|.:.||.:|...|||.:||||:.||:
  Rat   382 ILTTTAVRKIMN-CGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRY 445

  Fly   427 AGFLMSITNCSANLAGLLAPIAAGHLISDPSKPMMGQWQIVFFIAAFVYIICGTFYNIFGSGERQ 491
            |..||.|:|....|:|::.|:..|.:....::.   :||.||.|||.|:.....||.:|.|||:|
  Rat   446 ASILMGISNGVGTLSGMVCPLIVGAMTKHKTRE---EWQNVFLIAALVHYSGVIFYGVFASGEKQ 507

  Fly   492 YWDNPED---------DEQKPALQTTVT----TSP-ARLSNGST 521
            .|.:||:         |:.:.|.:|.:.    .|| .::|.|:|
  Rat   508 DWADPENLSEEKCGIIDQDELAEETELNHEAFVSPRKKMSYGAT 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Picot	NP_725600.1	2A0114euk	41..501	CDD:129972	159/471 (34%)
Picot	NP_725600.1	MFS	100..485	CDD:119392	132/387 (34%)
Slc17a8	NP_714947.1	MFS_SLC17A6_7_8_VGluT	79..502	CDD:340940	149/444 (34%)
Slc17a8	NP_714947.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..588		5/13 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342515
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.650