DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Picot and SLC17A5

DIOPT Version :9

Sequence 1:	NP_725600.1	Gene:	Picot / 36865	FlyBaseID:	FBgn0024315	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001369562.1	Gene:	SLC17A5 / 26503	HGNCID:	10933	Length:	533	Species:	Homo sapiens

Alignment Length:	434	Identity:	178/434 - (41%)
Similarity:	252/434 - (58%)	Gaps:	16/434 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 CFATRYFVTFMLFLGMANAYVMRTNMSVAIVAMV-NHTAIKSGEAEEYDDECGDRDIPI--DDSQ 97
            |.:.||.:..:.|.|....|.:|.|:|||:|.|| ::|.::.....:   .|.:...||  ..:|
Human    35 CCSARYNLAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSK---ACPEHSAPIKVHHNQ 96

  Fly    98 DG-EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARGGG 161
            .| ::.|.:..||:||.||||||:|||||.|.:|.|.|....||:|:|..:|.....|:|| ..|
Human    97 TGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAA-DLG 160

  Fly   162 VWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYGF 226
            |..|..:|.::|||||...|..|||.:.|.||.|||::.:..|||||.||:||:||||::..|
Human   161 VGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYY-- 223

  Fly   227 DGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSHPTIDEREKKYINDSLWGTDVVKSPPIPFKAII 291
             ..|..:||.||.:|..|.:.::..|.:.|..|..|...||:||..|| ...:.....:|:..|:
Human   224 -MNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSL-RNQLSSQKSVPWVPIL 286

  Fly   292 KSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVADW 356
            ||||.:||:.||..:|:.:.||:|.||||||::|||:::.||.|||||||..||..:.....||.
Human   287 KSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADN 351

  Fly   357 MISSKRFSHTATRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINHLD 421
            :.:...||....|::.:.||..||.|.|:||.:.|||.:|.:|.|||...|.|...|||.|||||
Human   352 LRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLD 416

  Fly   422 LTPRFAGFLMSITNCSANLAGLLAPIAAGHLISDPSKPMMGQWQ 465
            :.|.:||.|:.|||..|.:.|::.|:.|..|..|...    ||:
Human   417 IAPSYAGILLGITNTFATIPGMVGPVIAKSLTPDAGV----QWR 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Picot	NP_725600.1	2A0114euk	41..501	CDD:129972	176/429 (41%)
Picot	NP_725600.1	MFS	100..485	CDD:119392	158/366 (43%)
SLC17A5	NP_001369562.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Dileucine internalization motif	22..23
		MFS_SLC17A5	42..458	CDD:340939	175/427 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148602
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	1	1.010	-	-		D378598at33208
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.760