DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Picot and SLC17A8

DIOPT Version :9

Sequence 1:	NP_725600.1	Gene:	Picot / 36865	FlyBaseID:	FBgn0024315	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_647480.1	Gene:	SLC17A8 / 246213	HGNCID:	20151	Length:	589	Species:	Homo sapiens

Alignment Length:	467	Identity:	164/467 - (35%)
Similarity:	258/467 - (55%)	Gaps:	26/467 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 RYFVTFMLFLGMANAYVMRTNMSVAIVAMVNHTAIKSGEAEEYDDECGDRDIPIDDSQDGEFAWS 104
            ||.:..|..||...::.:|.|:.||||.|||::.:       |.|  |..:|     |..:|.|.
Human    75 RYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTV-------YVD--GKPEI-----QTAQFNWD 125

  Fly   105 SALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARGGGVWGLCAVR 169
            ....|.|..|||:||::||||.|.::.|:.:.|..|..:.:.|.....:|.|||......:| ||
Human   126 PETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMC-VR 189

  Fly   170 FIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYGFDGGWPSIF 234
            .:|||.||...|..|.|.:||.||.||||:....:.|:..|.:::|||:|:|.:|   .||.|:|
Human   190 ILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQY---IGWSSVF 251

  Fly   235 YVFGIVGTVWSIAFLIFVHEDPSSHPTIDEREKKYINDSLW-GTDVVKSPPI--PFKAIIKSLPF 296
            |::|:.|.:|.:.:|:..:|.|::||||...||.||..|:. |.:||.....  |:|....|||.
Human   252 YIYGMFGIIWYMFWLLQAYECPAAHPTISNEEKTYIETSIGEGANVVSLSKFSTPWKRFFTSLPV 316

  Fly   297 YAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVADWMISSK 361
            |||:.|:...::.:..|:...|.|.::|..|::...||||::|::.|.:.......:||::.|.:
Human   317 YAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQ 381

  Fly   362 RFSHTATRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINHLDLTPRF 426
            ..:.||.||::| .|.:|....|:........:.:.::.|.:.||.:|...|||.:||||:.||:
Human   382 ILTTTAVRKIMN-CGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRY 445

  Fly   427 AGFLMSITNCSANLAGLLAPIAAGHLISDPSKPMMGQWQIVFFIAAFVYIICGTFYNIFGSGERQ 491
            |..||.|:|....|:|::.|:..|.:....::.   :||.||.|||.|:.....||.:|.|||:|
Human   446 ASILMGISNGVGTLSGMVCPLIVGAMTRHKTRE---EWQNVFLIAALVHYSGVIFYGVFASGEKQ 507

  Fly   492 YWDNPED-DEQK 502
            .|.:||: .|:|
Human   508 EWADPENLSEEK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Picot	NP_725600.1	2A0114euk	41..501	CDD:129972	161/463 (35%)
Picot	NP_725600.1	MFS	100..485	CDD:119392	135/387 (35%)
SLC17A8	NP_647480.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..61
		2A0114euk	75..513	CDD:129972	160/459 (35%)
		MFS	80..502	CDD:119392	152/443 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148620
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.650