DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Picot and Slc17a8

DIOPT Version :9

Sequence 1:	NP_725600.1	Gene:	Picot / 36865	FlyBaseID:	FBgn0024315	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_892004.1	Gene:	Slc17a8 / 216227	MGIID:	3039629	Length:	601	Species:	Mus musculus

Alignment Length:	501	Identity:	168/501 - (33%)
Similarity:	269/501 - (53%)	Gaps:	43/501 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 RYFVTFMLFLGMANAYVMRTNMSVAIVAMVNHTAIKSGEAEEYDDECGDRDIPIDDSQDGEFAWS 104
            ||.:..|..||...::.:|.|:.||||.|||::.:       |.|  |..:|     |..:|.|.
Mouse    88 RYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTV-------YVD--GKPEI-----QTAQFNWD 138

  Fly   105 SALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAAR--GGGVWGLCA 167
            ....|.|..|||:||::||||.|.::.|:.:.|..|..:.:.|.....:|.|||  .|.|.|
Mouse   139 PETVGLIHGSFFWGYIVTQIPGGFISNKFAASRVFGAAIFLTSTLNMFIPSAARVHYGCVMG--- 200

  Fly   168 VRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYGFDGGWPS 232
            ||.:|||.||...|..|.|.:||.||.||||:....:.|:..|.:::|||:|:|.:|   .||.|
Mouse   201 VRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQY---IGWAS 262

  Fly   233 IFYVFGIVGTVWSIAFLIFVHEDPSSHPTIDEREKKYINDSLW-GTDVVKSPPI--PFKAIIKSL 294
            :||::|:.|.:|.:.:|:..:|.|::||||...|:.||..|:. |.::......  |::....||
Mouse   263 VFYIYGMFGIIWYMFWLLQAYECPAAHPTISNAERTYIETSIGEGANLASLSKFNTPWRRFFTSL 327

  Fly   295 PFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVADWMIS 359
            |.|||:.|:...::.:..|:...|.|.::|..|::...||||::|::.|.:.......:||::.|
Mouse   328 PVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRS 392

  Fly   360 SKRFSHTATRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINHLDLTP 424
            .|..:.||.||::| .|.:|....|:........:.:.::.|.:.||.:|...|||.:||||:.|
Mouse   393 RKILTTTAVRKIMN-CGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAP 456

  Fly   425 RFAGFLMSITNCSANLAGLLAPIAAGHLISDPSKPMMGQWQIVFFIAAFVYIICGTFYNIFGSGE 489
            |:|..||.|:|....|:|::.|:..|.:....::.   :||.||.|||.|:.....||.:|.|||
Mouse   457 RYASILMGISNGVGTLSGMVCPLIVGAMTKHKTRE---EWQNVFLIAALVHYSGVIFYGVFASGE 518

  Fly   490 RQYWDNPED---------DEQKPALQT-----TVTTSPARLSNGST 521
            :|.|.:||:         |:.:.|.:|     |..:...::|.|:|
Mouse   519 KQDWADPENLSEDKCGIIDQDELAEETELNHETFVSPRKKMSYGAT 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Picot	NP_725600.1	2A0114euk	41..501	CDD:129972	161/473 (34%)
Picot	NP_725600.1	MFS	100..485	CDD:119392	134/389 (34%)
Slc17a8	NP_892004.1	2A0114euk	88..526	CDD:129972	159/461 (34%)
		MFS	93..515	CDD:119392	151/445 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	576..601
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720