DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Picot and slc-17.4

DIOPT Version :9

Sequence 1:	NP_725600.1	Gene:	Picot / 36865	FlyBaseID:	FBgn0024315	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_503071.2	Gene:	slc-17.4 / 189054	WormBaseID:	WBGene00012130	Length:	573	Species:	Caenorhabditis elegans

Alignment Length:	524	Identity:	145/524 - (27%)
Similarity:	231/524 - (44%)	Gaps:	58/524 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 FATRYFVTFMLFLGMANAYVMRTNMSVAIVAMVNHTAIKSGEA---EEYDDE------------- 85
            |:.|..:..:...|......||.::::::..|:|.||:....|   |.:::.
Worm    27 FSRRLHICLLCMAGFCCTTFMRMHIAISMTCMINSTALALESAVFPEAFENSSSIFEELEPVSNG 91

  Fly    86 -CG-----DRDIPIDDSQDGEFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRF-----L 139
             |.     ::.:.:|  ..|:..|:|..|..|.|..|:|.:||.:|......:| |.|:     :
Worm    92 ACSSNADVNKKVVVD--YGGQLVWNSQEQNLIFSGTFWGSIITVLPSMFFINRY-SPRYVLQAAV 153

  Fly   140 GYGMLINSVFAFLVPVAARGGGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAVY 204
            |..:|:.::    .|..|...|.:.:...|.|.|||||.|:|..:|:||.|.|..|||...:...
Worm   154 GCYILMTAI----TPYIATRFGPYPVFISRVIMGLGEGFILPANNAILANWFPSAERSTAISLFT 214

  Fly   205 AGAQFGTIISMPLSGLLAEYGFDGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSHPTIDEREKKY 269
            .|.|.......|::..|....|  |||||||...||.|:||:.:.:.....||....:.:.|:.|
Worm   215 TGNQMAGAGGNPVAASLCASSF--GWPSIFYFASIVSTIWSVCWFLTASNQPSKCKVMTKTERDY 277

  Fly   270 INDSLWGTDVV-------KSPPIPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRF 327
            ::     .:||       :|..:|:..|:||..|.|.|......|:....|...||.|.|.||..
Worm   278 LD-----ANVVRRSNKTNRSLVVPYSKILKSPAFLAQLLCQFVINFIVTLLQIYLPNYFKDVLHL 337

  Fly   328 SLKSNGLLSSLPYLAMWLFSMFISVVADWMISSKRFSHTATRKLINSIGQYGPGVALIAASY-TG 391
            .:.:||..:|:|.:..:...:...:..|.....|..|.|...||..||..:|..:.||..:| ..
Worm   338 GVIANGTYTSVPNIVNFALKIVWGITIDRAKEKKIISGTFGVKLSQSIANFGGALFLILITYFVD 402

  Fly   392 C-DRALTLAILTIGVGLNGGIYSGFKINHLDLTPRFAGFLMSITNCSANLAGLLAPIAAGHLISD 455
            | :..|......:..|..|.:.|||..:.|.|.|::...:.||:...|.:..|..|...| ||.
Worm   403 CTNPTLGFVFFCMMYGCMGTLVSGFYTSLLSLAPKYTATMSSISVFCAMMGRLATPAIVG-LIK- 465

  Fly   456 PSKPMMGQWQIVFFIAAFVYIICGTFYNIFGSGERQYWDNPEDDEQKPALQTTVTTSPARLSNGS 520
             .:..:.:||.:|.:.|...||||..:.:|||||.|.|.  .:||.| .::|....:|  |::..
Worm   466 -KQNTLSEWQTLFLVCAAANIICGAVFLVFGSGELQEWG--LEDEAK-EMKTLAEKTP--LASIQ 524

  Fly   521 TAPA 524
            ..||
Worm   525 NLPA 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Picot	NP_725600.1	2A0114euk	41..501	CDD:129972	136/495 (27%)
Picot	NP_725600.1	MFS	100..485	CDD:119392	116/398 (29%)
slc-17.4	NP_503071.2	MFS	34..495	CDD:391944	128/477 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010