DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Picot and R10D12.1

DIOPT Version :9

Sequence 1:	NP_725600.1	Gene:	Picot / 36865	FlyBaseID:	FBgn0024315	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_506456.1	Gene:	R10D12.1 / 179888	WormBaseID:	WBGene00011185	Length:	485	Species:	Caenorhabditis elegans

Alignment Length:	518	Identity:	110/518 - (21%)
Similarity:	208/518 - (40%)	Gaps:	73/518 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VLVWNQRNLHESLEQQPQRCFATRYFVTFMLFLGMANAYVMRTNMSVAIVAMVNHTAI---KSGE 78
            |.:.:.::.::..:.||          .::.:|.|.:..:..|::...:|.. |.|.:   .|||
Worm    16 VAIPDTKSSNDDSKDQP----------GYVRYLIMISTMLCLTSLMSNVVCF-NFTVLCMPGSGE 69

  Fly    79 AEEYDDECGDRDIPIDDSQDGEFAWSSALQGY-------ILSSFFYGYVITQIPFGILAKKYGSL 136
            ..|.   .|:|               :...||       :||:...|.|....|..|...|.|..
Worm    70 TGEL---VGNR---------------THFVGYTRQEKTVLLSTVAIGAVCGVFPVIIGISKLGLK 116

  Fly   137 R-FLGYGMLINSVFAFLVPVAARGGGVWGL-----CAVRFIQGLGEGPIVPCTHAMLAKWIPPNE 195
            : |:..|:| .::..||:|:.|      .|     ..:||:|||......|...|:.:.|....:
Worm   117 KVFMTSGVL-TAISTFLIPILA------PLHFHLFIMLRFVQGLSYAACFPAVGAITSSWASLAQ 174

  Fly   196 RSRMGAAVYAGAQFGTIISMPLSGLLAEYGFDGGWPSIFYVFGIVG-TVWSIAFLIFVHEDPSSH 259
            :....||:....|..:|.|||::|.|....|  ||.|:||:..|:. .|::|.|.:|. :.|..:
Worm   175 QGLFIAALTTFGQTSSIFSMPVAGELCTSVF--GWKSVFYLHAIISLVVFTIWFALFT-DSPEDN 236

  Fly   260 PTIDEREKKYINDSLWGTDVVKSPPIPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQV 324
            ..:...|...|.......::.:....|:..|:.:...:.|.....|.....:.:....|.::..|
Worm   237 KLVRPAELAEIEFGKSEDEIHEHSNTPYLEILTTPSVWGIWIGAFGDLIAVQLIHIYSPVFLHDV 301

  Fly   325 LRFSLKSNGLLSSLPYLAMWLFSMFISVVADWMISSKRFSHTATRKLINSIGQYGPGVALIAASY 389
            ..:|.:..|..:::|.|..:...||....:|   .....|.|...::.|:|......:.|::..:
Worm   302 GGYSFEKTGFAAAVPVLFQFFVKMFAGHSSD---KVHGISETTKLRIYNTIALGASAIFLVSLGF 363

  Fly   390 TGCDR-ALTLAILTIGVGL---NGGIYSGFKINHLDLTPRFAGFLMSITNCSANLAGLLAPIAAG 450
            ....: .|.|.::|:..|:   |||   ||......::.::..|:|:|......|:.::.||...
Worm   364 VKQGQGVLGLVLMTLATGMFGFNGG---GFSKCAALVSRQYNHFVMAIQQILVCLSMIVCPIIVS 425

  Fly   451 HLISDPSKPMMGQWQIVFFIAAFVYIICGTFYNIFGSGERQYWDN----PEDDEQKPALQTTV 509
            .::...:   ..:|:||||:.|.:.:||...:....:.:...|.:    ....:..|..||.|
Worm   426 TILQHGT---TAEWRIVFFVHAAILLICNAIFCWLATAKPAPWTDRTIKHSATKNTPLYQTKV 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Picot	NP_725600.1	2A0114euk	41..501	CDD:129972	103/484 (21%)
Picot	NP_725600.1	MFS	100..485	CDD:119392	90/402 (22%)
R10D12.1	NP_506456.1	MFS	55..455	CDD:391944	99/437 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160311
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740