DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Picot and T22F3.8

DIOPT Version :9

Sequence 1:	NP_725600.1	Gene:	Picot / 36865	FlyBaseID:	FBgn0024315	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_504013.1	Gene:	T22F3.8 / 178781	WormBaseID:	WBGene00020698	Length:	482	Species:	Caenorhabditis elegans

Alignment Length:	512	Identity:	110/512 - (21%)
Similarity:	199/512 - (38%)	Gaps:	86/512 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 CFATRYF---VTFMLFLGMANAYVMRTNMSVAIVAM----------------VNHTAI--KSGEA 79
            |....:|   |.|  |||.|...:|..|.....:.:                :|.|.|  |...:
Worm    11 CLYRTFFNLKVAF--FLGSAGLTMMLLNNYYRFIVLLVGFLCLASLCSNYLIINFTFICMKHDFS 73

  Fly    80 EEYDDECGDRDIPIDDSQDGEFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGY-GM 143
            :.:.:..|.|....|.:.|.: .|       ||.:...|.:|..:|..:|..|||: ||..: ..
Worm    74 DGFTEINGTRQSIYDYTPDDK-KW-------ILWAVAAGTIIGTVPMNLLLVKYGA-RFPFFLSG 129

  Fly   144 LINSVFAFLVPVAARGGGVWG---LCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAVYA 205
            :::.:...|:|.||:    |.   |..:|||||............:..:|.|..|.:...|.:..
Worm   130 IVSCISTSLIPFAAK----WNFAFLIILRFIQGFSFSADFAAIGLLAVRWAPLAETAIFVAVLTC 190

  Fly   206 GAQFGTIISMPLSGLLAEYGFDGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSHPTIDEREKKYI 270
            .....::|:...:||:.....  ||...:|:..|||.:..:.:.....:.|.....:..:|.:.|
Worm   191 FNAIASMITNMATGLICVSSL--GWKWSYYLHSIVGAILFVLWYFVYIDHPQDTRRVSGKELQSI 253

  Fly   271 NDSLWGTDVVKSPPIPFKAIIKSLP---------FY----AILFAHMGHNYGYETLMTELPTYMK 322
            ..:.....:.|...:|:..:..| |         |:    ||:|:            |.:|.|:.
Worm   254 QKNKSEAHLSKKCDVPYIKLATS-PVILCVWANAFFDLTAAIMFS------------TYIPLYLH 305

  Fly   323 QVLRFSLKSNGLLSSLPYLAMWLFSMFISVVADWMISSKRFSHTATRKLINSIGQYGPG-----V 382
            :||:|.:...|..|||.:.......:...:::|   ..:..|.....::.|:|...|.|     :
Worm   306 EVLKFGVTETGFYSSLIHGICLPVRLCFGIISD---KIQFISEPVKIQIFNTISVGGSGLFFASI 367

  Fly   383 ALIAASYTGCDRALTLAILTIG-VGLN-GGIYSGFKINHLDLTPRFAGFLMSITNCSANLAGLLA 445
            .||...|.|.  ::...|:|:. :|:| ||.|   |:..|. :.:||..:::.......||..:|
Worm   368 GLIPMEYRGW--SVFSCIMTMSCIGVNPGGFY---KVAVLH-SRQFAHVVLTAIQWIKCLALFVA 426

  Fly   446 PIAAGHLISDPSKPMMGQWQIVFFIAAFVYIICGTFYNIFGSGERQYWDNPEDDEQK 502
            |......:::.|  :..||..||.|.....:|.......|.:.:...|.:.::..:|
Worm   427 PALVSIFVTNES--IRQQWIWVFLIVGGGMVITNILGFFFLTDKPAEWTDTDEPLEK 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Picot	NP_725600.1	2A0114euk	41..501	CDD:129972	108/504 (21%)
Picot	NP_725600.1	MFS	100..485	CDD:119392	89/408 (22%)
T22F3.8	NP_504013.1	MFS	87..464	CDD:391944	91/415 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160320
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740