Protein Alignment Nach and ASIC3

DIOPT Version :9

• Sequence 1: NP_001334724.1
• Gene: Nach / 36864
• FlyBaseID: FBgn0024319
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_064717.1
• Gene: ASIC3 / 9311
• HGNCID: 101
• Length: 549
• Species: Homo sapiens
• Alignment Length: 597
• Identity: 127/597 - (21%)
• Similarity: 209/597 - (35%)
• Gaps: 186/597 - (31%)

  Fly    24 RRTWSD---FCATSSIHGLKYTRDEDTNKIVHLVW---LLISVVMFICAVVMARTFYMDYRSSPT 82
            ||..||   |.:..|:|||.:.....:..:...:|   :::||..|:..|.....:|.::.....
Human    11 RRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTA 75

  Fly    83 RMNVESDNTPVNRLYFPPVTIC-----------PD-------VLFNMQKSE--AFLNTLRLPKGA 127
            ....||     :||.||.||:|           |:       .|..:..:|  |||..|..|...
Human    76 LDERES-----HRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPAP 135

  Fly   128 ELRGILRKLHIFYGFMLDDERYSAEDIEQMEALLFLNNLTIPEFVEHLRWNCDEILYRCRFNGEI 192
            .            |||..    ...|:.|:.|              ....:.|::|..|||.|:
Human   136 P------------GFMPS----PTFDMAQLYA--------------RAGHSLDDMLLDCRFRGQ- 169

  Fly   193 MDCS-KIFQLSKTFFGHCCSFNLRQKGWVNNKLNNLESFKVFHLNSLNFTAQRAIGGLRYGLSVV 256
             .|. :.|....|..|.|.:||....|                  :...|..|  ||:..||.::
Human   170 -PCGPENFTTIFTRMGKCYTFNSGADG------------------AELLTTTR--GGMGNGLDIM 213

  Fly   257 VRYKDDNYDPL------QSYSYGVKLLIQEADAFPSAHSAAKFIAFNSETFAAVRPQE-TF---- 310
            :..:.:.|.|:      ..:..|:::.|...:..|........::...:||.:.:.|: :|
Human   214 LDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPP 278

  Fly   311 ---CSSAVKALIIEERNCVFQNEFPMRYFSD------------YVYPNCELNCRVTNMVKFCGCH 360
               ||||       ..|..::.| |    ||            |....|.|.|....:.:.|||.
Human   279 WGDCSSA-------SLNPNYEPE-P----SDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCR 331

  Fly   361 TYFFDFNRTSDRICTFRDIPCLVDNFGRLLLICSKYSDFNRLLSA-NIITRKKSTQCYCPLTCEH 424
            ..:..           .|:|           :||.....|....| :.:.||.|  |.||..|..
Human   332 MVYMP-----------GDVP-----------VCSPQQYKNCAHPAIDAMLRKDS--CACPNPCAS 372

  Fly   425 IDYDVQLTNFPLELNM-----PVADKFYSG--------LAKNDGVLHVFINSFSYRRLRRDLLSN 476
                   |.:..||:|     ..|.:|.:.        :|:|...|.:|..:.:|..:.:.....
Human   373 -------TRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYE 430

  Fly   477 MVTLVSNLGSAFSLFVGMSMLSVVEIIYYFSVILRKNYKLECET-RSQMLHKKPKFAWPKANDTH 540
            |..|:.::|....||:|.|:|:::||:.|.           ||. |.::|    .:.|   |..|
Human   431 MSELLGDIGGQMGLFIGASLLTILEILDYL-----------CEVFRDKVL----GYFW---NRQH 477

  Fly   541 SKEQKSVFIIHK 552
            |:...|..::.:
Human   478 SQRHSSTNLLQE 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	None
ASIC3	NP_064717.1	ASC	20..534	CDD:295594	123/588 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..307		6/33 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152121
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41723
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4675
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.880