Protein Alignment Nach and asic1a

DIOPT Version :10

• Sequence 1: NP_001334724.1
• Gene: Nach / 36864
• FlyBaseID: FBgn0024319
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_999955.1
• Gene: asic1a / 791696
• ZFINID: ZDB-GENE-040513-2
• Length: 501
• Species: Danio rerio
• Alignment Length: 599
• Identity: 128/599 - (21%)
• Similarity: 214/599 - (35%)
• Gaps: 168/599 - (28%)

  Fly     7 LKPEQVDLKVTPFVGYLRRTWSD-----------FCATSSIHGLK--YTRDEDTNKIVHLVWLLI 58
            :|...:||||.|.         |           |..||::||:.  ::.::.|.|....|...:
Zfish     1 MKTSVMDLKVEPM---------DIDFDQPPPLQVFAHTSTLHGISHIFSYEKITAKCCLWVVFFL 56

  Fly    59 SVVMFICAVVMAR-TFYMDYRSSPTRMNVESDNTPVNRLYFPPVTICPDVLFNMQKSEAFLNTLR 122
            |.:.|:..|.:.| .||::|   |....::...|||  :.||.||||.            ||::|
Zfish    57 SSLTFLMYVCIDRIQFYLEY---PHVTKLDEITTPV--MVFPAVTICN------------LNSIR 104

  Fly   123 LPK--------GAELRGILRKLHIFYGFMLDDERYSAEDIEQ--MEAL--------LFLNNLTIP 169
            ..:        ..||..:|...|         |...|..:|:  ||.|        ....:..:.
Zfish   105 FSRITRNDLYHAGELLALLNSRH---------EVREAHLVEESVMEVLKSKTDFRSFKPRHFNMW 160

  Fly   170 EFVEHLRWNCDEILYRCRFNGEIM---DCSKIFQLSKTFFGHCCSFNLRQKG--WVNNKLNNLES 229
            ||......:..::|..|:|.|...   |.|.:|    |.:|.|.:||..:.|  .|:.|
Zfish   161 EFYNRTGHDIKDMLLSCQFRGSPCRPEDFSVVF----TRYGKCYTFNSGETGPPRVSVK------ 215

  Fly   230 FKVFHLNSLNFTAQRAIGGLRYGLSVVVRYKDDNYDPL------QSYSYGVKLLIQEADAFPSAH 288
                             ||:..||.:::..:.|.|.|:      .|:..|:|:.|...|..|...
Zfish   216 -----------------GGMGNGLEIMLDIQQDEYLPVWGESDESSFEAGIKVQIHSQDEPPFID 263

  Fly   289 SAAKFIAFNSETFAAVRPQETF--------CSSAVKALIIEERNCVFQNEFPMRYFSDYVYPNCE 345
            .....:|...:||.:.:.|...        |.|...:               ..||..|....|.
Zfish   264 QLGFGVAPGFQTFVSCQEQRLVYLPAPWGSCKSTPPS---------------SDYFRAYSISACR 313

  Fly   346 LNCRVTNMVKFCGCHTYFFDFNRTSDRICTFRDIPCLVDNFGRLLLICSKYSDFNRLLSANIITR 410
            .:|....:|:.|.|.......:..   .||    |.|........|      ||        :..
Zfish   314 TDCETRYLVENCNCRMVHMPGDAP---YCT----PVLYKECAHPAL------DF--------LVE 357

  Fly   411 KKSTQCYCPLTCEHIDYDVQLT--NFPLELNMPVADKFYSG----LAKNDGVLHVFINSFSYRRL 469
            ..|..|.|...|....|..:|:  ..|.:.::....|.||.    :.:|..||.||..:.:|..:
Zfish   358 TDSDYCSCETPCNITRYSKELSFVKIPSKASVKYLAKKYSKSEKYITENVMVLDVFFEALNYETI 422

  Fly   470 RRDLLSNMVTLVSNLGSAFSLFVGMSMLSVVEIIYYFSVILRKNYKLECETRSQMLHKKPKFAWP 534
            .:.....:..|:.::|....||:|.|:|:::|:..|...:::  |:| |...::..|
Zfish   423 EQRKAYEVAGLLGDIGGQMGLFIGASILTILELFDYLYEVMK--YRL-CRCSNKKHH-------- 476

  Fly   535 KANDTHSKEQKSVF 548
              |:.::.:..:||
Zfish   477 --NNNNNTDHNAVF 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	ASC	30..505	CDD:459966	113/520 (22%)
asic1a	NP_999955.1	ENaC	23..469	CDD:273304	116/537 (22%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:Q1XA76	446..448		1/1 (100%)