DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nach and Asic4

DIOPT Version :9

Sequence 1:	NP_001334724.1	Gene:	Nach / 36864	FlyBaseID:	FBgn0024319	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_071570.2	Gene:	Asic4 / 63882	RGDID:	621068	Length:	539	Species:	Rattus norvegicus

Alignment Length:	542	Identity:	107/542 - (19%)
Similarity:	202/542 - (37%)	Gaps:	136/542 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RTWSDFCATSSIHGLKYTRDEDTNKIVHLVWLLISVVMFICAVVMARTFYMDYRSSPTRMNVESD 89
            |..:.|.:||::|||........:.:...:|:|..:......:..|.:....|.:.|..:.:: .
  Rat    40 RDLATFASTSTLHGLGRACGPGPHGLRRTLWVLALLTSLAAFLYQAASLARGYLTRPHLVAMD-P 103

  Fly    90 NTPVNRLYFPPVTICPDVLFNMQK------SEAFLNTLRLPKGAELRGILRKLHIFYGFMLDDER 148
            ..|.....||.||:|     |:.:      |:|.:..|     |.|.|:..|         |.:.
  Rat   104 AAPAPVAGFPAVTLC-----NINRFRHSALSDADIFHL-----ANLTGLPPK---------DRDG 149

  Fly   149 YSAEDIEQMEALLFLNNLTIPEFVEHLR---WNCDEILYRCRFNGEIMDCSKIFQLSKTFFGHCC 210
            :.|..:...|          |:.|:.|.   ....::|..|.|:|.....|. |.:..|.:|.|.
  Rat   150 HRAAGLRYPE----------PDMVDILNRTGHQLADMLKSCNFSGHHCSASN-FSVVYTRYGKCY 203

  Fly   211 SFNLRQKGWVNNKLNNLESFKVFHLNSLNFTAQRAIGGLRYGLSVVVRYKDDNYDPL------QS 269
            :||.       :..::|.|              || ||:..||.:::..:.:.|.|:      .|
  Rat   204 TFNA-------DPQSSLPS--------------RA-GGMGSGLEIMLDIQQEEYLPIWRETNETS 246

  Fly   270 YSYGVKLLIQEADAFPSAHSAAKFIAFNSETFAAVRPQE-TF-------CSSAVKALIIEERNCV 326
            :..|:::.|...:..|..|.....::...:||.:.:.|. |:       |.:..|.
  Rat   247 FEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESKL--------- 302

  Fly   327 FQNEFPMRYFSDYVYPNCELNCRVTNMVKFCGCHTYFFDFNRTSDRICTFRDIPCLVDNFGRLLL 391
              .|..::.:|.|....|.|.|....:::.|.|.......|.|   ||.           ..:.:
  Rat   303 --REPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNET---ICP-----------PNIYI 351

  Fly   392 ICSKYSDFNRLLSANIITRKKSTQCYCPLTCEHIDYDVQLTNFPLELNMP----------VADKF 446
            .|:.:       :.:.:.......|:||..|       .||.:..|::|.          :|.|:
  Rat   352 ECADH-------TLDSLGGGSEGPCFCPTPC-------NLTRYGKEISMVKIPNRGSARYLARKY 402

  Fly   447 YSG---LAKNDGVLHVFINSFSYRRLRRDLLSNMVTLVSNLGSAFSLFVGMSMLSVVEIIYYFSV 508
            ...   :.:|..||.||..:.:...:.:.....:..|:.:||....||:|.|:|:::||:.|.
  Rat   403 NRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYI-- 465

  Fly   509 ILRKNYKLECETRSQMLHKKPK 530
                 |::..: |.:.:.::||
  Rat   466 -----YEVSWD-RLKRVWRRPK 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	None
Asic4	NP_071570.2	ASC	40..488	CDD:295594	107/542 (20%)
Asic4	NP_071570.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345628
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8907
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850