DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nach and Asic5

DIOPT Version :9

Sequence 1:	NP_001334724.1	Gene:	Nach / 36864	FlyBaseID:	FBgn0024319	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_071563.1	Gene:	Asic5 / 63866	RGDID:	69295	Length:	495	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	123/555 - (22%)
Similarity:	223/555 - (40%)	Gaps:	139/555 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGHQEELK-PEQVDLKVTPFVGYLRRTWS---------------DFCATSSIHGLKYTRDEDTNK 49
            |.|.|:.| |.:..|     :|.:||..|               ||..::|.||: :...::.||
  Rat     1 MEHTEKSKGPAEKGL-----LGKIRRYLSKRPLPSPTDRKKFDHDFAISTSFHGI-HNIAQNQNK 59

  Fly    50 IVHLVWLLISVVMFICAVVMARTF--YMDYRSSPTRMNVESDNTPVNRLYFPPVTICPDVLFNMQ 112
            :..::||  |||:...::::.:.:  .::|...||..::|...  |.::.||.||.|....|..:
  Rat    60 VRKVIWL--SVVLGSVSLLVWQIYSRLVNYFMWPTTTSIEVQY--VEKIEFPAVTFCNLNRFQTE 120

  Fly   113 KSEAFLNTLRLPKGAELRGILRKLHIFYGFMLDDERYSAEDIEQMEALLFL---NNLTIPEFVEH 174
            ....|             ||:..|......:|..:..|..:....|||.|:   .|.:|.|||::
  Rat   121 AVSRF-------------GIIFFLWDIVSKVLRLQEISGNNTGSPEALDFVASHRNFSITEFVKN 172

  Fly   175 --LRWNCDEILYRCRFNGEIMDCSKIFQLSKTFFGHCCSFNLRQKGWVNNKLNNLESFKVFHLNS 237
              ...|.|.::: |.|.|:..| .|.|:...|.:|:|.:||..:.....||:
  Rat   173 NGFYLNHDTLVH-CEFFGKTCD-PKDFKHVFTEYGNCFTFNYGENVQSKNKV------------- 222

  Fly   238 LNFTAQRAIGGLRYGLSVVVRYKDDNYDPLQSYS-YGVKLLIQEADAFPSAHSAAKFIAFNSETF 301
                   ::.|....|.:.|..::...:|:..:: .||..:|         ||..|...|:.
  Rat   223 -------SVSGRGLKLLLDVHQEEFTDNPVPGFADAGVIFVI---------HSPKKEPQFDG--- 268

  Fly   302 AAVRPQETFCSSAV---KALIIEERNCVFQNEFP---------MRYFSDYVYPNCELNCRVTNMV 354
                   ...||.|   ..:.|.:...:.| |:|         :|.|:.|....|...|:..::.
  Rat   269 -------LGLSSPVGMHARVTIRQLKTIHQ-EYPWGECNPDIKLRNFTTYSTYGCLKECKAKHIQ 325

  Fly   355 KFCGCHTYFFDFNRTS-DRICTFRDIPCLVDNFGRLLLICSKYSDFNRLLSANIITRKKSTQCYC 418
            :.|||..:....|... |.:..:..:..::|:..|..| |:            :.|...|    |
  Rat   326 RLCGCLPFLLPGNGVECDLLKYYNCVSPILDHIERKGL-CT------------MGTHNSS----C 373

  Fly   419 PLTCEHIDY--DVQLTNFPLELNMPVADKFYSGLAK---------NDGVLHVFIN--SFSYRRLR 470
            |:.||..:|  .:..:.||.:.    |.||   |||         .:.::::.||  ..:|:..:
  Rat   374 PVPCEETEYPATIAYSTFPSQR----ATKF---LAKKLNQSQEYIRENLVNIEINYSDLNYKITQ 431

  Fly   471 RDLLSNMVTLVSNLGSAFSLFVGMSMLSVVEIIYY 505
            :....::..|::::|....||.|.|:::::|||.|
  Rat   432 QQKAVSVPELLADVGGQLGLFCGASLITIIEIIEY 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	None
Asic5	NP_071563.1	deg-1	40..465	CDD:273309	111/508 (22%)
Asic5	NP_071563.1	ASC	41..466	CDD:279230	111/508 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8907
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820