Protein Alignment Nach and SCNN1B

DIOPT Version :10

• Sequence 1: NP_001334724.1
• Gene: Nach / 36864
• FlyBaseID: FBgn0024319
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: XP_016879014.1
• Gene: SCNN1B / 6338
• HGNCID: 10600
• Length: 659
• Species: Homo sapiens
• Alignment Length: 633
• Identity: 130/633 - (20%)
• Similarity: 222/633 - (35%)
• Gaps: 201/633 - (31%)

  Fly    21 GYLRR---TWSDFCATSSIHGLKYTRDEDTNKIVHLVWLLISVVMFICAV-----VMARTFYMDY 77
            ||..:   .|  :|..::.||.|....|...|  ..:|.|:: ::|...|     :..|| |:.:
Human    38 GYTYKELLVW--YCDNTNTHGPKRIICEGPKK--KAMWFLLT-LLFAALVCWQWGIFIRT-YLSW 96

  Fly    78 RSSPTRMNVESDNTPVNRLYFPPVTICPDVLFNMQKSEAFLNTLRLPKGAELRGIL--------- 133
            ..|      .|.:.....:.||.||||....|...|.:..|..|.....|.|..||
Human    97 EVS------VSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELMEAVLERILAPELSHANA 155

  Fly   134 -RKLHI----FYGFMLDDER---------------------------YSAEDIEQMEALLFLN-- 164
             |.|:.    ....:|.|||                           .:|...:....|..||
Human   156 TRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSLNRT 220

  Fly   165 -----NLT--------------------IP--EFVEHLRWNCDEILYRCRFNGEIMDCSKIFQLS 202
                 |.|                    :|  |.|| :.:..::::..|.|..|..:......:.
Human   221 QCTFRNFTSATQALTEWYILQATNIFAQVPQQELVE-MSYPGEQMILACLFGAEPCNYRNFTSIF 284

  Fly   203 KTFFGHCCSFN--LRQKGWVNNKLNNLESFKVFHLNSLNFTAQRAIGGLRYGLSVVVRYKDDNYD 265
            ...:|:|..||  :.:|.                |.|.|       .|..:||.:::....::|.
Human   285 YPHYGNCYIFNWGMTEKA----------------LPSAN-------PGTEFGLKLILDIGQEDYV 326

  Fly   266 PLQSYSYGVKLLIQEADAFPSAHSAAKFIAFNSETFAAV------RPQETFCSSAVKALIIEERN 324
            |..:.:.||:|::.|..::|.......:....:||...|      |..|.:....|..
Human   327 PFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNG------- 384

  Fly   325 CVFQNEFPMR-YFSDY--VY--PNCELNCRVTNMVKFCGCHTYFFDFNRTSDRICTFRDIP---- 380
                :|.|:: ::|||  .|  ..|..:|...:|::.|.|..|.:...| .::.|..||.|
Human   385 ----SEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPR-GEKYCNNRDFPDWAH 444

  Fly   381 CLVDNFGRLLLICSKYSDFNRLLSANIITRKKSTQCYCPLTCEHIDY--DVQLTNFPLE------ 437
            |              |||...     .:.::::....|..:|....|  .:.:.::|.|
Human   445 C--------------YSDLQM-----SVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWI 490

  Fly   438 -----------LNMPVADKFYSGLAKNDGVLHVFINSFSYRRLRRDLLSNMVTLVSNLGSAFSLF 491
                       .|:.::.|   |:.|    |:::...|:||.:.....:|:|.|:||||..|..:
Human   491 FHVLSQERDQSTNITLSRK---GIVK----LNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFW 548

  Fly   492 VGMSMLSVV---EIIYYF-------SVILRKNYKLECETRSQMLHKKP 529
            :|.|:|.::   |||..|       .|.|.|:.:   :.|:|..:..|
Human   549 MGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLR---QRRAQASYAGP 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	ASC	30..505	CDD:459966	120/588 (20%)
SCNN1B	XP_016879014.1	ENaC	40..642	CDD:273304	128/631 (20%)