Protein Alignment Nach and Asic5

DIOPT Version :10

• Sequence 1: NP_001334724.1
• Gene: Nach / 36864
• FlyBaseID: FBgn0024319
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_067345.1
• Gene: Asic5 / 58170
• MGIID: 1929259
• Length: 495
• Species: Mus musculus
• Alignment Length: 511
• Identity: 118/511 - (23%)
• Similarity: 210/511 - (41%)
• Gaps: 116/511 - (22%)

  Fly    29 DFCATSSIHGLKYTRDEDTNKIVHLVWLLISVVMFICAVVMARTFYMDYRSSPTRMNVESDNTPV 93
            ||..::|.||: :...::.||:..::||.:.:......|....:..::|.:.||..::|...  |
Mouse    40 DFAMSTSFHGI-HNIAQNQNKVRKVIWLAVVLGSVSLLVWQIYSRLVNYFTWPTTTSIEVQY--V 101

  Fly    94 NRLYFPPVTICPDVLFNMQKSEAFLNTLRLPKGAELRGILRKLHIFYGFMLDDERYSAEDIEQME 158
            .::.||.||:|....|..:....|             ||:..|......:|..:..||.:....|
Mouse   102 EKIEFPAVTLCNLNRFQTEAVSRF-------------GIIFFLWDIVSKVLRLQEISANNTGSPE 153

  Fly   159 ALLFL---NNLTIPEFVEH--LRWNCDEILYRCRFNGEIMDCS-KIFQLSKTFFGHCCSFNLRQK 217
            .|.|:   .|.:|.|||::  ...|.|.::: |.|.|:  .|| |.|:...|.:|:|.:||..:.
Mouse   154 TLDFVTNHQNFSITEFVKNNGFYLNNDTLVH-CEFFGK--TCSPKDFKHVFTEYGNCFTFNYGEN 215

  Fly   218 GWVNNKLNNLESFKVFHLNSLNFTAQRAIGGLRYGLSVVVRYKDDNYDPLQSYS-YGVKLLIQEA 281
              :.||            |.::.:.:    ||:..|.|......||  |:..:: .||..:|
Mouse   216 --IQNK------------NKVSVSGR----GLKLLLDVHQEEFTDN--PVPGFADAGVIFVI--- 257

  Fly   282 DAFPSAHSAAKFIAFNSETFAAVRPQETFCSSAV---KALIIEERNCVFQNEFP---------MR 334
                  ||..|...|:.          ...||.|   ..:.|.:...|.| |:|         :|
Mouse   258 ------HSPKKEPQFDG----------LGLSSPVGMHARVTIRQLKTVHQ-EYPWGECNPNIKLR 305

  Fly   335 YFSDYVYPNCELNCRVTNMVKFCGCHTYFFDFNRTS-DRICTFRDIPCLVDNFGRLLLICSKYSD 398
            .|..|....|...|:..::.:.|||..:....|... |.:..:..:..::|:..|..| |:
Mouse   306 NFITYSTYGCLKECKARHIQRLCGCLPFLLPGNGVECDLLEYYNCVSPILDHIERKGL-CT---- 365

  Fly   399 FNRLLSANIITRKKSTQCYCPLTCEHIDY--DVQLTNFPLELNMPVADKFYSGLAK--------- 452
                    :.|...|    ||::||..:|  .|..:.||.:.    |.:|   |||
Mouse   366 --------MGTHNSS----CPVSCEETEYPATVSYSTFPSQR----ATRF---LAKKLNQSQEYI 411

  Fly   453 NDGVLHVFIN--SFSYRRLRRDLLSNMVTLVSNLGSAFSLFVGMSMLSVVEIIYYF 506
            .:.::::.||  ..:|:..::....::..|::::|....||.|.|:::::|||.||
Mouse   412 RENLVNIEINYSDLNYKITQQQKAVSVPELLADVGGQLGLFCGASLITIIEIIEYF 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	ASC	30..505	CDD:459966	115/507 (23%)
Asic5	NP_067345.1	Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000250|UniProtKB:Q9R0W5	1..30
		ASC	41..466	CDD:459966	115/507 (23%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	454..456		1/1 (100%)