DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nach and ASIC5

DIOPT Version :10

Sequence 1:NP_001334724.1 Gene:Nach / 36864 FlyBaseID:FBgn0024319 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_059115.1 Gene:ASIC5 / 51802 HGNCID:17537 Length:505 Species:Homo sapiens


Alignment Length:515 Identity:114/515 - (22%)
Similarity:204/515 - (39%) Gaps:126/515 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 DFCATSSIHGLKYTRDEDTNKIVHLVWLLISVVMFICAVVMARTF--YMDYRSSPTRMNVESDNT 91
            ||..::|.||: :...::.:||..::||:  ||:...::|..:.:  .::|.:.||..::|... 
Human    40 DFAISTSFHGI-HNIVQNRSKIRRVLWLV--VVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQY- 100

  Fly    92 PVNRLYFPPVTICPDVLFNMQKSEAFLNTLRLPKGAELRGILRKLHIFYGFMLDDERYSAEDIEQ 156
             |.::.||.||.|.            ||..:....|:. |::..|......:|..:..:|.....
Human   101 -VEKMEFPAVTFCN------------LNRFQTDAVAKF-GVIFFLWHIVSKVLHLQEITANSTGS 151

  Fly   157 MEALLFL---NNLTIPEFVEHLRWNC-DEILYRCRFNGEIMDCS-KIFQLSKTFFGHCCSFN--- 213
            .||..|.   .|.:|.||:.:..:.. :..|..|.|.|:  .|| |.|....|.:|:|.:||   
Human   152 REATDFAASHQNFSIVEFIRNKGFYLNNSTLLDCEFFGK--PCSPKDFAHVFTEYGNCFTFNHGE 214

  Fly   214 -LRQKGWVNNKLNNLESFKVFHLNSLNFTAQRAIGGLRYGLSVVVRYKDDNYDPLQSYSYGVKLL 277
             |:.|..|:.....|.  .:|::|...||...|:|.:..|:..|:                    
Human   215 TLQAKRKVSVSGRGLS--LLFNVNQEAFTDNPALGFVDAGIIFVI-------------------- 257

  Fly   278 IQEADAFPSAHSAAKFIAFNSETFAAVRPQETFCSSAVKALIIEERNCVFQNEFP---------M 333
                      ||..|...|:.  ...:.|.....     .:.|.:...|.| |:|         :
Human   258 ----------HSPKKVPQFDG--LGLLSPVGMHA-----RVTIRQVKTVHQ-EYPWGECNPNIKL 304

  Fly   334 RYFSDYVYPNCELNCRVTNMVKFCGCHTYFFDFNRTSDRICTFRDIPCLVDNFGRLLLIC--SKY 396
            :.||.|....|...|:..::.|.|||                   :|.|:..:|   :.|  .||
Human   305 QNFSSYSTSGCLKECKAQHIKKQCGC-------------------VPFLLPGYG---IECDLQKY 347

  Fly   397 ----------SDFNRLLSANIITRKKSTQCYCPLTCEHIDY--DVQLTNFPLELNMPVADKFYSG 449
                      .:|..|.:..  |...|    ||::||.|:|  .:..::||.:..:....|..:.
Human   348 FSCVSPVLDHIEFKDLCTVG--THNSS----CPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQ 406

  Fly   450 LAK--NDGVLHVFIN--SFSYRRLRRDLLSNMVTLVSNLGSAFSLFVGMSMLSVVEIIYY 505
            ..|  .:.::.:.||  ..:|:..::....::..|:::||....||.|.|:::::|||.|
Human   407 SRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEY 466

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NachNP_001334724.1 ASC 30..505 CDD:459966 112/512 (22%)
ASIC5NP_059115.1 Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000250|UniProtKB:Q9R0W5 1..30
ASC 41..466 CDD:459966 112/512 (22%)
GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348 454..456 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

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