DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nach and asic1c

DIOPT Version :9

Sequence 1:	NP_001334724.1	Gene:	Nach / 36864	FlyBaseID:	FBgn0024319	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_021325802.1	Gene:	asic1c / 407670	ZFINID:	ZDB-GENE-040513-3	Length:	562	Species:	Danio rerio

Alignment Length:	544	Identity:	117/544 - (21%)
Similarity:	196/544 - (36%)	Gaps:	160/544 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 FCATSSIHGLKYTRDEDTNKIVHLVWLLISVVMFICAVVM-----ARTFYMDYRSSPTRMNVESD 89
            |...:.:||||:......:|...|.|||   .:.:|..::     .|..|:....:.|::.:...
Zfish    41 FVLRTKVHGLKHAFSPHKSKTQRLFWLL---ALLVCLGLLFTWSWNRILYLLSYPAVTKIYMVWS 102

  Fly    90 NTPVNRLYFPPVTICPDVLFNMQKSEAFLNTLRLPKGAELRGILRKLHIFY-GFMLD----DERY 149
                |.:.||.:|.|..            |.||:..       |.:..::| |:.:|    :...
Zfish   103 ----NNMTFPAITFCNQ------------NRLRVSS-------LTRDDLYYSGYWMDILHLNHTL 144

  Fly   150 SAEDIEQM------EALLFL-----------NNLTIPEFVEHLRWNCDEILYRCRFNGEIMDCS- 196
            :.:.:..:      |.||.|           .:|...|.::.|.....::|..|||.||  :|:
Zfish   145 NRQSVSMLKHSRHRERLLHLLDFSHYSPPPDQSLNTTEMIDRLGHQLQDMLLECRFRGE--NCTY 207

  Fly   197 KIFQLSKTFFGHCCSFNLRQKGWVNNKLNNLESFKVFHLNSLNFTAQRAIGGLRYGLSVVVRYKD 261
            |.|....|.:|.|.:||....|  |..|..|:                  ||...||.:::..:.
Zfish   208 KNFTPIYTRYGKCYTFNSGLDG--NPLLTTLK------------------GGTGNGLEIMLDIQQ 252

  Fly   262 DNYDPL------QSYSYGVKLLIQEADAFPSAHSAAKFIAFNSETFAAVRPQETF--------CS 312
            |.|.|:      .||..|:|:.|...|..|........:|...:||.:.:.|...        |.
Zfish   253 DEYLPVWGDTDETSYEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQQQLLLYLPPPWGDCR 317

  Fly   313 SAVKALIIEERNCVFQNEFPM--RYFSDYVYPNCELNCRVTNMVKFCGCHTYFFDFNRTSDRICT 375
            ||                 ||  .|||.|....|.::|....:::.|.|.........|   :||
Zfish   318 SA-----------------PMDSEYFSTYSITACRIDCETRYLLENCNCRMVHMPGTST---VCT 362

  Fly   376 ---FRDI--PCLVDNFGRLLLICSKYSDFNRLLSANIITRKKSTQCYCPLTCEHIDYDVQLTNFP 435
               ::|.  |.|               ||        :..|.:..|.|...|       .:|.:.
Zfish   363 PEQYKDCADPAL---------------DF--------LVEKDNDYCVCDTPC-------NMTRYG 397

  Fly   436 LELNMP----------VADKFYSG---LAKNDGVLHVFINSFSYRRLRRDLLSNMVTLVSNLGSA 487
            .||:|.          :|.||...   :..|..||.:|..:.:|.::.:.....:..|:.::|..
Zfish   398 KELSMVKIPSKASAKYLAKKFNKTEQYITDNILVLDIFFEALNYEKIEQKKAYEVAGLLGDIGGQ 462

  Fly   488 FSLFVGMSMLSVVEIIYYFSVILR 511
            ..||:|.|:|:::||..|...:|:
Zfish   463 MGLFIGASVLTILEIFDYLYEVLK 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	None
asic1c	XP_021325802.1	ASC	34..531	CDD:322155	117/544 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586602
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26495
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850