Protein Alignment Nach and asic4a

DIOPT Version :10

• Sequence 1: NP_001334724.1
• Gene: Nach / 36864
• FlyBaseID: FBgn0024319
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_999952.1
• Gene: asic4a / 407668
• ZFINID: ZDB-GENE-040513-5
• Length: 539
• Species: Danio rerio
• Alignment Length: 570
• Identity: 126/570 - (22%)
• Similarity: 213/570 - (37%)
• Gaps: 139/570 - (24%)

  Fly     4 QEELKPEQVDLKVTPFVGYLRRTWSDFCATSSIHGLKYTRDEDTNKIVHLVW---LLISVVMFIC 65
            :|...|...||             :.|.:.||:||:.:........:...:|   .|:|:.:|:.
Zfish    31 EESCSPPTKDL-------------AGFASASSLHGINHIFVSGRLGVRQTLWALAFLVSLALFLY 82

  Fly    66 AVVMARTFYMDYRSSPTRMNVESDNTPVNRLYFPPVTICPDVLFNMQK-SEAFLNTLRLPKGAEL 129
            ........|::: ...|.:|.|:  ||  .:.||.||||....|.... ::|.:..|     |.|
Zfish    83 QAAKCAISYLEH-PHVTALNEEA--TP--EMVFPAVTICNINRFRFSALTDADIYHL-----ANL 137

  Fly   130 RGILRKLHIFYGFMLDDERYSAEDIEQMEALLFLNNLTIPEFVEHLRWNCDEILYRCRFNGEIMD 194
            .|:..|..  .|....|..|.|.|::              :.........:|:|..|.|:|:  :
Zfish   138 TGLPPKNK--DGHKPTDLEYPAPDMQ--------------DIFNRTGHQLEEMLKSCNFSGQ--N 184

  Fly   195 CS-KIFQLSKTFFGHCCSFNLRQKGWVNNKLNNLESFKVFHLNSLNFTAQRAIGGLRYGLSVVVR 258
            || :.|.:..|.:|.|.:||       .||..:.:            |.|   ||:..||.:::.
Zfish   185 CSAEDFTVVYTRYGKCYTFN-------GNKTTSRK------------TKQ---GGMGNGLEIMLD 227

  Fly   259 YKDDNYDPL------QSYSYGVKLLIQEADAFPSAHSAAKFIAFNSETFAAVRPQETFCSSAVKA 317
            .:.|:|.|:      .|...|:::.|...|..|..|.....::...:||.:.:.|.      :..
Zfish   228 IQQDDYLPIWKETNETSLEAGIRVQIHSQDEPPYIHQLGFGVSPGFQTFVSCQEQR------LTY 286

  Fly   318 LIIEERNCVFQNEFPMRYFSDYVYPNCELNCRVTNMVKFCGCHTYFF--DFNRTSDRICTFRDIP 380
            |.....||...:|..:..:..|....|.|.|....:::.|.|.....  |.|     |||..||.
Zfish   287 LPQPWGNCRSTSEQMIPGYDTYSISACRLRCETLEVLRECKCRMVHMPGDAN-----ICTPSDIK 346

  Fly   381 CLVDNFGRLLLICSKYSDFNRLLSANIITRKKSTQCYCPLTCEHIDYDVQLTNFPLELNMPVA-- 443
            | ||.                  :..::.:.....|:|...|       .||.:..||:|...
Zfish   347 C-VDK------------------ALALLQKSSGDTCFCETPC-------NLTRYGKELSMVKIPS 385

  Fly   444 -----------DKFYSGLAKNDGVLHVFINSFSYRRLRRDLLSNMVTLVSNLGSAFSLFVGMSML 497
                       ||....:..|..||.:|..:.:|..:.:....::..|:.::|....||:|.|:|
Zfish   386 KGSARYLSRKYDKSEDYIRDNFLVLDIFFEALNYETIEQKKAYDVAGLLGDIGGQMGLFIGASVL 450

  Fly   498 SVVEII-YYFSVILRKNYKLECETRSQMLHKKPKFAWPKANDTHSKEQKS 546
            :::||: |.:.||   .::||...|.|...||         .|..::|.|
Zfish   451 TILEILDYVYEVI---KHRLERLLRPQRDDKK---------QTQQQQQAS 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	ASC	30..505	CDD:459966	110/501 (22%)
asic4a	NP_999952.1	ENaC	44..472	CDD:273304	115/517 (22%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	446..448		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	474..494		6/24 (25%)