DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nach and asic4a

DIOPT Version :9

Sequence 1:	NP_001334724.1	Gene:	Nach / 36864	FlyBaseID:	FBgn0024319	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_999952.1	Gene:	asic4a / 407668	ZFINID:	ZDB-GENE-040513-5	Length:	539	Species:	Danio rerio

Alignment Length:	570	Identity:	126/570 - (22%)
Similarity:	213/570 - (37%)	Gaps:	139/570 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QEELKPEQVDLKVTPFVGYLRRTWSDFCATSSIHGLKYTRDEDTNKIVHLVW---LLISVVMFIC 65
            :|...|...||             :.|.:.||:||:.:........:...:|   .|:|:.:|:.
Zfish    31 EESCSPPTKDL-------------AGFASASSLHGINHIFVSGRLGVRQTLWALAFLVSLALFLY 82

  Fly    66 AVVMARTFYMDYRSSPTRMNVESDNTPVNRLYFPPVTICPDVLFNMQK-SEAFLNTLRLPKGAEL 129
            ........|::: ...|.:|.|:  ||  .:.||.||||....|.... ::|.:..|     |.|
Zfish    83 QAAKCAISYLEH-PHVTALNEEA--TP--EMVFPAVTICNINRFRFSALTDADIYHL-----ANL 137

  Fly   130 RGILRKLHIFYGFMLDDERYSAEDIEQMEALLFLNNLTIPEFVEHLRWNCDEILYRCRFNGEIMD 194
            .|:..|..  .|....|..|.|.|::              :.........:|:|..|.|:|:  :
Zfish   138 TGLPPKNK--DGHKPTDLEYPAPDMQ--------------DIFNRTGHQLEEMLKSCNFSGQ--N 184

  Fly   195 CS-KIFQLSKTFFGHCCSFNLRQKGWVNNKLNNLESFKVFHLNSLNFTAQRAIGGLRYGLSVVVR 258
            || :.|.:..|.:|.|.:||       .||..:.:            |.|   ||:..||.:::.
Zfish   185 CSAEDFTVVYTRYGKCYTFN-------GNKTTSRK------------TKQ---GGMGNGLEIMLD 227

  Fly   259 YKDDNYDPL------QSYSYGVKLLIQEADAFPSAHSAAKFIAFNSETFAAVRPQETFCSSAVKA 317
            .:.|:|.|:      .|...|:::.|...|..|..|.....::...:||.:.:.|.      :..
Zfish   228 IQQDDYLPIWKETNETSLEAGIRVQIHSQDEPPYIHQLGFGVSPGFQTFVSCQEQR------LTY 286

  Fly   318 LIIEERNCVFQNEFPMRYFSDYVYPNCELNCRVTNMVKFCGCHTYFF--DFNRTSDRICTFRDIP 380
            |.....||...:|..:..:..|....|.|.|....:::.|.|.....  |.|     |||..||.
Zfish   287 LPQPWGNCRSTSEQMIPGYDTYSISACRLRCETLEVLRECKCRMVHMPGDAN-----ICTPSDIK 346

  Fly   381 CLVDNFGRLLLICSKYSDFNRLLSANIITRKKSTQCYCPLTCEHIDYDVQLTNFPLELNMPVA-- 443
            | ||.                  :..::.:.....|:|...|       .||.:..||:|...
Zfish   347 C-VDK------------------ALALLQKSSGDTCFCETPC-------NLTRYGKELSMVKIPS 385

  Fly   444 -----------DKFYSGLAKNDGVLHVFINSFSYRRLRRDLLSNMVTLVSNLGSAFSLFVGMSML 497
                       ||....:..|..||.:|..:.:|..:.:....::..|:.::|....||:|.|:|
Zfish   386 KGSARYLSRKYDKSEDYIRDNFLVLDIFFEALNYETIEQKKAYDVAGLLGDIGGQMGLFIGASVL 450

  Fly   498 SVVEII-YYFSVILRKNYKLECETRSQMLHKKPKFAWPKANDTHSKEQKS 546
            :::||: |.:.||   .::||...|.|...||         .|..::|.|
Zfish   451 TILEILDYVYEVI---KHRLERLLRPQRDDKK---------QTQQQQQAS 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	None
asic4a	NP_999952.1	ASC	44..472	CDD:295594	115/517 (22%)
asic4a	NP_999952.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..494		6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586598
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26596
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850