DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nach and rpk

DIOPT Version :9

Sequence 1:	NP_001334724.1	Gene:	Nach / 36864	FlyBaseID:	FBgn0024319	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001246909.1	Gene:	rpk / 40580	FlyBaseID:	FBgn0022981	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	131/549 - (23%)
Similarity:	222/549 - (40%)	Gaps:	79/549 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TWSDFCATSSIHGLKYTRDEDTNKIVHLVWLLISVVMFICAVVMARTFYMDYRSSPTRMNVESDN 90
            |:.::|..:||||::|..:::......:.||.:.::.......:.::.|..:..:|..::....:
  Fly    35 TYHEYCRNTSIHGVQYLGEQERPFRERIFWLFVFLISIYGCSTLIQSAYTKWTETPVIVSFAEKS 99

  Fly    91 TPVNRLYFPPVTICPD---VLFNMQKSEAFLNTLRLPKGAELRGILRKLHIFYGFMLDDERYSAE 152
            |||..:.||.||:|.:   ||....|...:.:..     ::....:|...:|     ..|..||.
  Fly   100 TPVWNIPFPAVTVCSETKRVLKQKGKETTYADLY-----SQFSEDMRASRVF-----RPENVSAL 154

  Fly   153 DIEQMEALLFLNNLTIPE---------------FVEHLRWNCDEILYRCRFNGEIMDCSKIFQLS 202
            ::|:...||.:.|..|.|               .::.:....|...:.||:.....:|...|:.:
  Fly   155 EMEEFRTLLHVCNTQIIEEDIPLIAGDDLDYFDVLQRMLPQFDRYFFYCRWLSRFGECETFFRKT 219

  Fly   203 KTFFGHCCSFN-LR------------QKGWVNNKLNNLESFKV-------FHLNS--LNFTAQRA 245
            .|..|.|.:|| ||            |......::.|:.|...       :.|:|  ..|.|:..
  Fly   220 LTEEGICYTFNGLRATEIYRDDTYQYQHSGEPLEMENISSQHTAWTLETGYALDSDVETFPARVL 284

  Fly   246 IGGLRYGLSVVVRYKDDNYD-----PLQSYSYG--VKLLIQEADAFPSAHSAAKFIAFNSETFAA 303
            ..|.|.|:.:.::......|     |:|.:..|  ..:|:...|..|........|....|...|
  Fly   285 SAGARSGIFLALQSFKQEVDYACRGPVQGFKVGKFENVLLHAPDDVPQVSKQFVRIPMGKEVLIA 349

  Fly   304 VRPQETFCSSAVKALIIEERNCVFQNEFPMRYFSDYVYPNCELNCRVTNMVKFCGCHTYFFDFNR 368
            |:|.....||.:.......|.|...:|..:|:|..|...||:|.|.....:..|||  ..|...|
  Fly   350 VKPNMITMSSGIAEYHPVRRQCFLSHERSLRFFKVYTESNCQLECLANFTLTKCGC--VKFSMPR 412

  Fly   369 TSDR-ICTFRDIPCLVDNFGRLLLICSKYSDFNRLLSANI---ITRKKSTQCYCPLTCEHIDYDV 429
            ..|. :|....|.| .|...|.||:    .:|.|:.:.|.   .:|...:.|.|...|..:.|:.
  Fly   413 NVDMPVCGEDKIHC-YDRAERELLV----REFKRVKALNAGRENSRSVESACNCMPACTSLVYNT 472

  Fly   430 QLT--NFPLELNMPVAD------KFYSGLAKNDGVLHVFINSFSYRRLRRDLLSNMVTLVSNLGS 486
            :::  ||.|| .|.||:      |.|.|...:.  |.::.....:...:|..|..|...::|.|.
  Fly   473 EISQANFDLE-EMLVAEGDTEFLKEYPGSQMSR--LSIYFKQSQFITSKRSELYGMTEFLANCGG 534

  Fly   487 AFSLFVGMSMLSVVEIIYYFSVILRKNYK 515
            .|.||:|.|:||:||:||:|::.|..|.|
  Fly   535 IFGLFMGFSILSLVEMIYHFTLRLFTNLK 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	None
rpk	NP_001246909.1	ASC	39..552	CDD:279230	124/532 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456724
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112386at6656
OrthoFinder	1	1.000	-	-		FOG0000867
OrthoInspector	1	1.000	-	-		otm24766
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	P	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.850