Protein Alignment Nach and scnn1a

DIOPT Version :10

• Sequence 1: NP_001334724.1
• Gene: Nach / 36864
• FlyBaseID: FBgn0024319
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_001184124.1
• Gene: scnn1a / 395013
• XenbaseID: XB-GENE-996083
• Length: 633
• Species: Xenopus tropicalis
• Alignment Length: 646
• Identity: 142/646 - (21%)
• Similarity: 237/646 - (36%)
• Gaps: 198/646 - (30%)

  Fly     5 EELKPEQVDLKVTPFVGYLRRTWSDFCATSSIHGLKYTRDEDTNKIVHLVWLLISVVMFICAVVM 69
            :|:|.|:..|  ..|....|..:..||:.::|||........:|::....||::.:..|......
 Frog     3 KEVKNEKEPL--IEFFSSYRELFEFFCSNTTIHGAIRLVCSRSNRMKTAFWLVLFLATFGLMYWQ 65

  Fly    70 ARTFYMDYRSSPT--RMNVESDNTPVNRLYFPPVTICPDVLFNMQKSEAFLNTLR---------- 122
            ....:..|.|.|.  .:||.||..|     ||.||:|   ..|..:.:|..|.|:
 Frog    66 FGLLFGQYFSYPVSINLNVNSDKLP-----FPAVTVC---TLNPYRYKAIQNDLQELDKETQRTL 122

  Fly   123 ----------------------------------LPKGA------------ELRGILRKLHIFYG 141
                                              :|.|:            ||:...|:.:|  |
 Frog   123 YELYKYNSTGVQGWIPTNQRVRRDRPGLPHLLELVPPGSKTHRVSRSVIEEELQVKRREWNI--G 185

  Fly   142 FMLDDE--------RYSA--EDIEQMEALLFLNNLT-IPEFVEHLRWNCDEILYRCRFNGEIMDC 195
            |.|.:|        .|::  :.|.:.....::|.|. :||.........:..::.||||.|....
 Frog   186 FKLCNETGGDCFYQTYTSGVDAIREWYRFHYINILARVPEEAAIDGEQLENFIFACRFNEESCTK 250

  Fly   196 SKIFQLSKTFFGHCCSFNLRQKGWVNNKLNNLESFKVFHLNSLNFTAQRAIGGLRYGLSVVVRYK 260
            :.........:|:|.:||..:.|     .:||.|              .::.|::.||::::|.:
 Frog   251 ANYSHFHHAIYGNCYTFNQNRSG-----QSNLWS--------------SSMPGIKNGLTLILRTE 296

  Fly   261 DDNYDPLQSYSYGVKLLI--QEADAF---------PSAHSAAKFIAFNSETFAAVRPQETFCSSA 314
            ..:|.||.|...|.::|:  .:..||         |...::   |....||...:..:.:.||
 Frog   297 QHDYIPLLSSVAGARVLVHGHKEPAFMDDSGFNIPPGMETS---IGMKKETVNRMGGKYSDCS-- 356

  Fly   315 VKALIIEERNCV-FQNEFPMRYFSDYVYPNCELNCRVTNMVKFCGCHTYFF---------DFNR- 368
                  |:.:.| .:|.|.    |:|....|..:|....||:.|||...|:         |:|:
 Frog   357 ------EDGSDVDVKNLFE----SEYTEQVCVRSCFQAAMVERCGCGYAFYPLSPGDEFCDYNKH 411

  Fly   369 --------------TSDRICTFRDI--PCLVDNFGRLLLICSKYSDFNRLLSANIITRKKSTQCY 417
                          ||:::..|...  ||||..:    .:.:.||.:...:|.:.:....|.|
 Frog   412 KSWGHCYYKLIIEFTSNKLGCFSKCRKPCLVSEY----QLTAGYSKWPNRVSQDWVFHTLSRQ-- 470

  Fly   418 CPLTCEHIDYDVQLTNFPLELNMPVADKFYSGLAKNDGVLHVFINSFSYRRLRRDLLSNMVTLVS 482
                     |::...|               |:||    |:::....:|:.::.....|||.|:|
 Frog   471 ---------YNLTDRN---------------GIAK----LNIYFEELNYKTIQESPTINMVMLLS 507

  Fly   483 NLGSAFSLFVGMSMLSVVE---------IIYYFSVILRKNYKL--ECETRSQMLHKKPKFA 532
            .|||.:||:.|.|:|||||         ||....:..|..||.  |.|..|.:....|.||
 Frog   508 LLGSQWSLWFGSSVLSVVEMLELVIDLVIIVLIMLFHRYYYKQADEGEATSAVPTPAPSFA 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	ASC	30..505	CDD:459966	127/590 (22%)
scnn1a	NP_001184124.1	ENaC	18..602	CDD:273304	137/629 (22%)