DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nach and ppk12

DIOPT Version :9

Sequence 1:	NP_001334724.1	Gene:	Nach / 36864	FlyBaseID:	FBgn0024319	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	132/555 - (23%)
Similarity:	226/555 - (40%)	Gaps:	79/555 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 FVGYLRRTWSDFCATSSIHGLKYTRDEDTNKIVHLVWLLISVVMFICAVVMARTFYMDYRSSPTR 83
            ||..||:    |...:|:||||:..|...:......:|...|...|..|.:....|:.:.|:|..
  Fly    22 FVRSLRQ----FLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLISNIYVKWDSTPVI 82

  Fly    84 MNVESDNTPVNRLYFPPVTICPDVLFNMQKSEAFLNTLRLPKGAELRGILRKLHIFYGFMLDDER 148
            :.:....|.:.::.||.:|||     ||.:.:..| .....:|:....:|:.|      ...|..
  Fly    83 IGISPQATSILKVPFPAITIC-----NMNQVQRSL-VANYREGSNESALLKLL------CESDSW 135

  Fly   149 YSAEDIEQMEALLFL-NNLTIPEFVEHLRWNCDEILYRCRFNGEIMDCSKIFQLSKTFFGHCCSF 212
            .|:|..|:..|..|: |||.|.|||.:...:|:.:|..|||:....:||::||...|..|.||.|
  Fly   136 ESSEADEEFSASNFVTNNLKISEFVSNHSQSCERMLLFCRFSAVERNCSQLFQQILTDEGLCCVF 200

  Fly   213 NLR-----QKGWVNN--KLNNLESFKVF----------HLNSLNFTAQRAIGGLRYGLSVVVRYK 260
            |.:     .|.:.||  .|.|.:.|:..          .|....:.|..:..|:..|.:.|:..:
  Fly   201 NFQPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGTGITLGFTAVLDAE 265

  Fly   261 DDNYDPLQSYSYGVKLLIQEADAFPSAHSAAKFIAFNSETFAAVRPQETFCSSAVKALIIEERNC 325
            ...|....:...|.|:........|....|....|...||...:.........|::::..:.|.|
  Fly   266 MGEYYCSSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAVPAIRSISRDGRQC 330

  Fly   326 VFQNEFPMRYFSDYVYPNCELNCRVTNMVKFCGCHTYFFDFNRTSDRICTFRDIPCLVDNFGRLL 390
            :|:||..:.::..|...|||..|....:...|.|..:......::..||:..|..|:
  Fly   331 LFKNEKELIFYRIYTRLNCENECLAAFLYDTCSCIPFDHPLIYSNASICSMGDTSCV-------- 387

  Fly   391 LICSKYSDFNRLLSANIITRKKSTQC--YCPLTCEHIDYDVQLTNFPL-----ELNMPVADKF-Y 447
                     .|...|:  .|....:|  .|..:|..::|.....:|||     :|...:.:.| .
  Fly   388 ---------RRAQRAS--NRPGWAKCRQQCLPSCFDLNYLASGFSFPLASNNFQLANALVESFNK 441

  Fly   448 SGLAKNDGVLHVFINSFSYRRLRRDLLSNMVTLVSNLGSAFSLFVGMSMLSVVEIIYYFSVILRK 512
            |.|:||..|::|:.....|....::....:...:||:|....||:|.|::|:.||:|:  :||:.
  Fly   442 SYLSKNIAVINVYFRESVYYGNTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAEILYF--LILKP 504

  Fly   513 NYKLECETRSQMLHKKPKFAWPKANDTHSKEQKSV 547
            ..:|              |.|.::  :|...:||:
  Fly   505 LAEL--------------FVWKRS--SHVDSEKSL 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	None
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	119/505 (24%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	119/500 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456706
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112386at6656
OrthoFinder	1	1.000	-	-		FOG0000867
OrthoInspector	1	1.000	-	-		otm24766
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	P	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.850