DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nach and Asic3

DIOPT Version :9

Sequence 1:	NP_001334724.1	Gene:	Nach / 36864	FlyBaseID:	FBgn0024319	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_038963092.1	Gene:	Asic3 / 286920	RGDID:	708578	Length:	564	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	113/555 - (20%)
Similarity:	198/555 - (35%)	Gaps:	147/555 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RRTWSD---FCATSSIHGLKYTRDEDTNKIVHLVW---LLISVVMFICAVVMARTFYMDYRSSPT 82
            ||..||   |.::.::|||.:........:...:|   :|:|:..|:..|.....:|.::....|
  Rat    12 RRQASDIRVFASSCTMHGLGHIFGPGGLTLRRGLWATAVLLSLAAFLYQVAERVRYYGEFHHKTT 76

  Fly    83 RMNVESDNTPVNRLYFPPVTICPDVLFNMQKSEAFLNTLRLPKGAELRGILRKLHIFY------- 140
            ....||     ::|.||.||:|.  :..:::|....|.|.. .|..|.|:....|..|
  Rat    77 LDERES-----HQLTFPAVTLCN--INPLRRSRLTPNDLHW-AGTALLGLDPAEHAAYLRALGQP 133

  Fly   141 ----GFMLDDERYSAEDIEQMEALLFLNNLTIPEFVEHLRWNCDEILYRCRFNGEIMDCS-KIFQ 200
                |||..    ...|:.|:.|              ....:.:::|..||:.|:  .|. :.|.
  Rat   134 PAPPGFMPS----PTFDMAQLYA--------------RAGHSLEDMLLDCRYRGQ--PCGPENFT 178

  Fly   201 LSKTFFGHCCSFNLRQKGWVNNKLNNLESFKVFHLNSLNFTAQRAIGGLRYGLSVVVRYKDDNYD 265
            :..|..|.|.:||....|                 ..|..|.:   ||...||.:::..:.:.|.
  Rat   179 VIFTRMGQCYTFNSGAHG-----------------AELLTTPK---GGAGNGLEIMLDVQQEEYL 223

  Fly   266 PL------QSYSYGVKLLIQEADAFPSAHSAAKFIAFNSETFAAVRPQE-TF-------CSSAVK 316
            |:      ..:..|:::.|...|..|:........|...:||.:.:.|: :|       |::|
  Rat   224 PIWKDMEETPFEVGIRVQIHSQDEPPAIDQLGFGAAPGHQTFVSCQQQQLSFLPPPWGDCNTA-- 286

  Fly   317 ALIIEERNCVFQNEF------PM-----RYFSDYVYPNCELNCRVTNMVKFCGCHTYFFDFNRTS 370
                    .:..::|      |:     |....|....|.|.|....:.:.|||.......|..
  Rat   287 --------SLDPDDFDPEPSDPLGSPRPRPSPPYSLIGCRLACESRYVARKCGCRMMHMPGNSP- 342

  Fly   371 DRICTFRDIPCLVDNFGRLLLICS--KYSD-FNRLLSANIITRKKSTQCYCPLTCEHIDY--DVQ 430
                                 :||  :|.| .:..|.|.:   :|.| |.||..|....|  ::.
  Rat   343 ---------------------VCSPQQYKDCASPALDAML---RKDT-CVCPNPCATTRYAKELS 382

  Fly   431 LTNFPLELNMPVADKFY----SGLAKNDGVLHVFINSFSYRRLRRDLLSNMVTLVSNLGSAFSLF 491
            :...|...:.....:.|    |.:.:|..||.:|..:.:|..:.:.....:..|:.::|....||
  Rat   383 MVRIPSRASARYLARKYNRSESYITENVLVLDIFFEALNYEAVEQKAAYEVSELLGDIGGQMGLF 447

  Fly   492 VGMSMLSVVEIIYYFSVILRKNYKLECETRSQMLH 526
            :|.|:|:::||:.|.           ||......|
  Rat   448 IGASLLTILEILDYL-----------CEVGKNPRH 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	None
Asic3	XP_038963092.1	ASC	17..547	CDD:413546	110/550 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345624
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8907
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850