Protein Alignment Nach and Scnn1a

DIOPT Version :10

• Sequence 1: NP_001334724.1
• Gene: Nach / 36864
• FlyBaseID: FBgn0024319
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_113736.1
• Gene: Scnn1a / 25122
• RGDID: 3639
• Length: 699
• Species: Rattus norvegicus
• Alignment Length: 602
• Identity: 132/602 - (21%)
• Similarity: 219/602 - (36%)
• Gaps: 177/602 - (29%)

  Fly     8 KPEQVDLKVTPFVGYLRRTWSDFCATSSIHGLKYTRDEDTNKIVHLVWLLISVVMFICAVVMA-- 70
            :|.:.:..:..|....|..:..||..::|||.........|::....|    .|:::|...|.
  Rat    66 QPTEEEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFW----AVLWLCTFGMMYW 126

  Fly    71 --RTFYMDYRSSPTRMNVESDNTPVNRLYFPPVTIC---------------------PDVLFNMQ 112
              ...:.:|.|.|..:|:   |...::|.||.||:|                     ...||::.
  Rat   127 QFALLFEEYLSYPVSLNI---NLNSDKLVFPAVTVCTLNPYRYTEIKEELEELDRITEQTLFDLY 188

  Fly   113 KSE-------------------AF---LNTLRLP----KGAELRG-----------ILRKLHIFY 140
            |..                   ||   |..||.|    .|...|.           :.|| ....
  Rat   189 KYNSSYTRQAGARRRSSRDLLGAFPHPLQRLRTPPPPYSGRTARSGSSSVRDNNPQVDRK-DWKI 252

  Fly   141 GFMLDDER--------YSA--EDIEQMEALLFLNNL-----TIPEFVEHLRWNCDEILYRCRFNG 190
            ||.|.::.        ||:  :.:.:.....::|.|     |.|...|....|   .::.||||.
  Rat   253 GFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLSDTSPALEEEALGN---FIFTCRFNQ 314

  Fly   191 EIMDCSKIFQLSKTFFGHCCSFNLRQKG--WVNNKLNNLESFKVFHLNSLNFTAQRAIGGLRYGL 253
            ...:.:...:.....:|:|.:||.:...  |::                       ::.|:..||
  Rat   315 APCNQANYSKFHHPMYGNCYTFNDKNNSNLWMS-----------------------SMPGVNNGL 356

  Fly   254 SVVVRYKDDNYDPLQSYSYGVKLLIQEADAFPSAHSAAKFIAFNSETFAAVRP-QETFCSSAVKA 317
            |:.:|.:.:::.||.|...|.::::...|. |         ||..:....:|| .||..|...:|
  Rat   357 SLTLRTEQNDFIPLLSTVTGARVMVHGQDE-P---------AFMDDGGFNLRPGVETSISMRKEA 411

  Fly   318 LIIEERN---CVFQ-NEFPMR--YFSDYVYPNCELNCRVTNMVKFCGCHTYFFDFNRTSDRICTF 376
            |.....|   |... ::.|::  |.|.|....|..:|...||:|.||| .|.|.........|.:
  Rat   412 LDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGC-AYIFYPKPKGVEFCDY 475

  Fly   377 RDIPCLVDNFGRLLLICSKYSD----FNRLLSANIITRKKSTQCY--CPLTCEHIDYDVQ--LTN 433
            |                 |.|.    :.:|..|..:   .|..|:  |...|..|:|.:.  .:.
  Rat   476 R-----------------KQSSWGYCYYKLQGAFSL---DSLGCFSKCRKPCSVINYKLSAGYSR 520

  Fly   434 FP-------------LELNMPVADKFYSGLAKNDGVLHVFINSFSYRRLRRDLLSNMVTLVSNLG 485
            :|             |:.|..:.:| .:|:||    |::|....:|:.........||:|:||||
  Rat   521 WPSVKSQDWIFEMLSLQNNYTINNK-RNGVAK----LNIFFKELNYKTNSESPSVTMVSLLSNLG 580

  Fly   486 SAFSLFVGMSMLSVVEI 502
            |.:||:.|.|:|||||:
  Rat   581 SQWSLWFGSSVLSVVEM 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	ASC	30..505	CDD:459966	129/580 (22%)
Scnn1a	NP_113736.1	ENaC	80..677	CDD:273304	130/588 (22%)