DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nach and Asic4

DIOPT Version :9

Sequence 1:	NP_001334724.1	Gene:	Nach / 36864	FlyBaseID:	FBgn0024319	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_036020902.1	Gene:	Asic4 / 241118	MGIID:	2652846	Length:	586	Species:	Mus musculus

Alignment Length:	563	Identity:	113/563 - (20%)
Similarity:	207/563 - (36%)	Gaps:	131/563 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RTWSDFCATSSIHGLKYTRDEDTNKIVHLVWLLISVVMFICAVVMARTFYMDYRSSPTRMNVESD 89
            |..:.|.:||::|||........:.:...:|.|..:......:..|.:....|.:.|..:.:: .
Mouse    40 RDLATFASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAASLARGYLTRPHLVAMD-P 103

  Fly    90 NTPVNRLYFPPVTICPDVLFNMQK------SEAFLNTLRLPKGAELRGILRKLHIFYGFMLDDER 148
            ..|.....||.||:|     |:.:      |:|.:..|     |.|.|:..|         |.:.
Mouse   104 AAPAPVAGFPAVTLC-----NINRFRHSALSDADIFHL-----ANLTGLPPK---------DRDG 149

  Fly   149 YSAEDIEQMEALLFLNNLTIPEFVEHLR---WNCDEILYRCRFNGEIMDCSKIFQLSKTFFGHCC 210
            :.|..:...|          |:.|:.|.   ....::|..|.|:|.....|. |.:..|.:|.|.
Mouse   150 HRAAGLRYPE----------PDMVDILNRTGHQLADMLKSCNFSGHHCSASN-FSVVYTRYGKCY 203

  Fly   211 SFNLRQKGWVNNKLNNLESFKVFHLNSLNFTAQRAIGGLRYGLSVVVRYKDDNYDPL------QS 269
            :||.       :..::|.|              || ||:..||.:::..:.:.|.|:      .|
Mouse   204 TFNA-------DPQSSLPS--------------RA-GGMGSGLEIMLDIQQEEYLPIWRETNETS 246

  Fly   270 YSYGVKLLIQEADAFPSAHSAAKFIAFNSETFAAVRPQETFCSSAVKALIIEERNCVFQNEF--- 331
            :..|:::.|...:..|..|.....::...:||.:.:.|.      :..|.....||..::|.
Mouse   247 FEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQR------LTYLPQPWGNCRAESELREP 305

  Fly   332 PMRYFSDYVYPNCELNCRVTNMVKFCGCHTYFFD-------------FNRTSDRICTFRDIPCLV 383
            .::.:|.|....|.|.|....:::.|.|......             .:|||.|....|.....:
Mouse   306 ELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGGHLQPVFGATLLSSRTSRRQRCMRTTCTRI 370

  Fly   384 DNFGRLLLICSKYSDFNR--LLSANI-----------ITRKKSTQCYCPLTCEHIDYDVQLTNFP 435
            ....|:|:..|.|.....  :...||           :.......|:||..|       .||.:.
Mouse   371 YTHERVLMCMSGYLHMGNETICPPNIYIECADHTLDSLGGGSEGPCFCPTPC-------NLTRYG 428

  Fly   436 LELNMP----------VADKFYSG---LAKNDGVLHVFINSFSYRRLRRDLLSNMVTLVSNLGSA 487
            .|::|.          :|.|:...   :.:|..||.||..:.:...:.:.....:..|:.:||..
Mouse   429 KEISMVKIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQQAAYGLSALLGDLGGQ 493

  Fly   488 FSLFVGMSMLSVVEIIYYFSVILRKNYKLECETRSQMLHKKPK 530
            ..||:|.|:|:::||:.|.       |::..: |.:.:.::||
Mouse   494 MGLFIGASILTLLEILDYI-------YEVSWD-RLKRVWRRPK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	None
Asic4	XP_036020902.1	ASC	40..535	CDD:413546	113/563 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842198
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8693
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840