Protein Alignment Nach and Scnn1g

DIOPT Version :9

• Sequence 1: NP_001334724.1
• Gene: Nach / 36864
• FlyBaseID: FBgn0024319
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_035456.1
• Gene: Scnn1g / 20278
• MGIID: 104695
• Length: 655
• Species: Mus musculus
• Alignment Length: 658
• Identity: 134/658 - (20%)
• Similarity: 247/658 - (37%)
• Gaps: 190/658 - (28%)

  Fly    10 EQVDLKV---TPFVGYLRRTWSD----FCATSSIHGLK---YTRDEDTNKIVHLVWL-----LIS 59
            |::..|:   .|..|....|..|    :|..::.||.:   .:|    .::..|:|:     .::
Mouse     5 EKIKAKIKKNLPVRGPQAPTIKDLMHWYCLNTNTHGCRRIVVSR----GRLRRLLWIAFTLTAVA 65

  Fly    60 VVMFICAVVMARTFYMDYRSSPTRMNVESDNTPVNRLYFPPVTIC----------PDVLFNM--- 111
            ::::.||:::. :||        .::| |......:|.||.||||          .|:|.::
Mouse    66 LIIWQCALLVF-SFY--------TVSV-SIKVHFQKLDFPAVTICNINPYKYSAVSDLLTDLDSE 120

  Fly   112 --------------------QKSEA-------------FLNTLRL------PKG----------A 127
                                ::.||             |||.:.|      .||          .
Mouse   121 TKQALLSLYGVKDVLDSTPRKRREAGSMRSTWEGTPPRFLNLIPLLVFNENEKGKARDFFTGRKR 185

  Fly   128 ELRG-ILRK----LHI-----FYGFML------DDERYSAED----IEQMEALLFLNNLT-IP-E 170
            ::.| |:.|    :|:     ..||.|      |...|:...    |::...|.::|.:. :| |
Mouse   186 KISGKIIHKASNVMHVHESKKLVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLE 250

  Fly   171 FVEHLRWNCDEILYRCRFNGEIMDCSKIFQLSKTFFGHCCSFNLRQKGWVNNKLNNLESFKVFHL 235
            ...::.::.:|:|..|.|:|...|...........:|:|.:||.|:...:
Mouse   251 KKINMSYSAEELLVTCFFDGMSCDARNFTLFHHPMYGNCYTFNNRENATI--------------- 300

  Fly   236 NSLNFTAQRAIGGLRYGLSVVVRYKDDNYDPLQSYSYGVKLLIQEADAFPSAHSAAKFIAFNSET 300
                  ...::||..|||.|::...:|.|:|....|.|.|:|:.:.:.:|........|.....|
Mouse   301 ------LSTSMGGSEYGLQVILYINEDEYNPFLVSSTGAKVLVHQQNEYPFIEDVGTEIETAMST 359

  Fly   301 FAAVRPQETFCSSAVKALIIEERNCVFQNEFPMR--YFSDYVYPNCELNCRVTNMVKFCGCHTYF 363
            ...:...|:|..|...:...|:     .::.|:.  |.:.|....|..:|..|.||:.|||..|.
Mouse   360 SIGMHLTESFKLSEPYSQCTED-----GSDVPVTNIYNAAYSLQICLYSCFQTKMVEKCGCAQYS 419

  Fly   364 FDFNRTSDRICTFRDIPCLVDNFGRLLLICSKYSDFNRLLSANIITRKKSTQCYCPLTCEHIDYD 428
            ......:: .|.::..|    |:    :.|     :.:|..| .:..:...|..|..:|...::.
Mouse   420 QPLPPAAN-YCNYQQHP----NW----MYC-----YYQLYQA-FVREELGCQSVCKQSCSFKEWT 469

  Fly   429 V--QLTNFPLE------LNMPVAD---KFYSGLAKND-GVLHVFINSFSYRRLRRDLLSNMVTLV 481
            :  .|..:|.|      ||:...|   :....|.|.| ..|.:|....:.|.:.....:::..|:
Mouse   470 LTTSLAQWPSEASEKWLLNVLTWDQSQQINKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLL 534

  Fly   482 SNLGSAFSLFVGMSMLSVVEIIY-----YFSVILRKNYKLECETRSQMLHKKPKFAW-----PKA 536
            ||.|....|::..|::.|:|||.     :||:|.|:.:            :|.|..|     |.:
Mouse   535 SNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQW------------QKAKDWWARRRTPPS 587

  Fly   537 NDTHSKEQ 544
            .:|.|.:|
Mouse   588 TETPSSQQ 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	None
Scnn1g	NP_035456.1	ENaC	24..636	CDD:273304	130/639 (20%)
		deg-1	32..557	CDD:273309	116/579 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	582..636		4/14 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842196
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I5144
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8693
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4675
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.830