DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nach and Scnn1b

DIOPT Version :10

Sequence 1:NP_001334724.1 Gene:Nach / 36864 FlyBaseID:FBgn0024319 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_035455.1 Gene:Scnn1b / 20277 MGIID:104696 Length:638 Species:Mus musculus


Alignment Length:582 Identity:115/582 - (19%)
Similarity:199/582 - (34%) Gaps:164/582 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 GYLRR---TWSDFCATSSIHGLKYTRDEDTNKIVHLVWLLISVVMFICAVVMA-RTFYMDYRSSP 81
            ||..:   .|  :|..::.||.|....|...|  ..:|.|:: ::|.|.|... ..|...|.|..
Mouse    19 GYTYKELLVW--YCNNTNTHGPKRIICEGPKK--KAMWFLLT-LLFACLVCWQWGVFIQTYLSWE 78

  Fly    82 TRMNVESDNTPVNRLYFPPVTICPDVLFNMQKSEAFLNTLRLPKGAELRGIL----------RKL 136
            ..:::......:|   ||.||:|....|...|.:..|..|.....|.|..||          |.|
Mouse    79 VSVSLSMGFKTMN---FPAVTVCNSSPFQYSKVKHLLKDLDELMEAVLEKILAPEASHSNTTRTL 140

  Fly   137 HI----FYGFMLDDER-------------------------YSAEDIEQMEALLFLN-------N 165
            :.    ....:|.|||                         .:|:..:....|...|       |
Mouse   141 NFTIWNHTPLVLIDERNPDHPVVLNLFGDSHNSSNPAPGSTCNAQGCKVAMRLCSANGTVCTLRN 205

  Fly   166 LT---------------------IPEFVEHLRWNCDEILYRCRFNGEIMDCS-----KIFQLSKT 204
            .|                     :|:.:..:.:..|.|:..|.|..|  .||     .||...  
Mouse   206 FTSATQAVTEWYILQATNIFSQVLPQDLVGMGYAPDRIILACLFGTE--PCSHRNFTPIFYPD-- 266

  Fly   205 FFGHCCSFNLRQKGWVNNKLNNLESFKVFHLNSLNFTAQRAIGGLRYGLSVVVRYKDDNYDPLQS 269
             :|:|..||     |                .....|...|..|..:||.:::....::|.|..:
Mouse   267 -YGNCYIFN-----W----------------GMTEETLPSANPGTEFGLKLILDIGQEDYVPFLA 309

  Fly   270 YSYGVKLLIQEADAFPSAHSAAKFIAFNSETFAAV------RPQETFCSSAVKALIIEERNCVFQ 328
            .:.|.:|::.|...:|.......:....:||...|      |..|.:....:..     .:...:
Mouse   310 STAGARLMLHEQRTYPFIREEGIYAMAGTETSIGVLVDKLQRKGEPYSPCTMNG-----SDVAIK 369

  Fly   329 NEFPMRYFSDYVYPNCELNCRVTNMVKFCGCHTYFFDFNRTSDRICTFRDIPCLVDNFGRLLLIC 393
            |.:.: |.:.|....|..:|...:|::.|.|..|.:.... .::.|..||.|...          
Mouse   370 NLYSV-YNTTYSIQACLHSCFQDHMIRNCSCGHYLYPLPE-GEKYCNNRDFPDWA---------- 422

  Fly   394 SKYSDFNRLLSANIITRKKSTQCYCPLTCEHIDY--DVQLTNFPLEL-----------------N 439
              |...|..:|   :|::::....|..:|....|  .:.:.::|.|.                 |
Mouse   423 --YCYLNLQMS---VTQRETCLSMCKESCNDTQYKMTISMADWPSEASEDWILHVLSQERDQSSN 482

  Fly   440 MPVADKFYSGLAKNDGVLHVFINSFSYRRLRRDLLSNMVTLVSNLGSAFSLFVGMSMLSVVE 501
            :.::.|   |:.|    |:::...|:||.:.....:|:|.|:||||..|..::|.|:|.::|
Mouse   483 ITLSRK---GIVK----LNIYFQEFNYRTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLIE 537

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NachNP_001334724.1 ASC 30..505 CDD:459966 112/570 (20%)
Scnn1bNP_035455.1 ENaC 21..621 CDD:273304 113/580 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 594..620
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P51168 614..618
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.