Protein Alignment Nach and Scnn1a

DIOPT Version :9

• Sequence 1: NP_001334724.1
• Gene: Nach / 36864
• FlyBaseID: FBgn0024319
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_035454.2
• Gene: Scnn1a / 20276
• MGIID: 101782
• Length: 700
• Species: Mus musculus
• Alignment Length: 647
• Identity: 137/647 - (21%)
• Similarity: 224/647 - (34%)
• Gaps: 206/647 - (31%)

  Fly     5 EELKPEQVDLKVTPFVGYLRRTWSDFCATSSIHGLKYTRDEDTNKIVHLVWLLISVVMFICAVVM 69
            |..:|.:.:..:..|....|..:..||..::|||.........|::....|    .|:::|...|
Mouse    63 EPRQPTEEEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFW----AVLWLCTFGM 123

  Fly    70 A----RTFYMDYRSSPTRMNVESDNTPVNRLYFPPVTIC---------------------PDVLF 109
            .    ...:.:|.|.|..:|:   |...::|.||.||:|                     ...||
Mouse   124 MYWQFALLFEEYFSYPVSLNI---NLNSDKLVFPAVTVCTLNPYRYTEIKEDLEELDRITEQTLF 185

  Fly   110 NMQKSEAFLNTL---RLPKGAELRGIL-------------------------------------- 133
            ::.|..:.....   |.....:|||.|
Mouse   186 DLYKYNSSYTRQAGGRRRSTRDLRGALPHPLQRLRTPPPPNPARSARSASSSVRDNNPQVDRKDW 250

  Fly   134 ---------RKLHIFYGFMLDDERYSA--EDIEQMEALLFLNNL-----TIPEFVEHLRWNCDEI 182
                     .|...||      :.||:  :.:.:.....::|.|     |.|...|..   ....
Mouse   251 KIGFQLCNQNKSDCFY------QTYSSGVDAVREWYRFHYINILSRLPDTSPALEEEA---LGSF 306

  Fly   183 LYRCRFNGEIMDCSKIFQLSKTFFGHCCSFNLRQKGWVNNKLNNLESFKVFHLNSLNFTAQRAIG 247
            ::.||||....:.:...|.....:|:|.:||       |...:||              ...::.
Mouse   307 IFTCRFNQAPCNQANYSQFHHPMYGNCYTFN-------NKNNSNL--------------WMSSMP 350

  Fly   248 GLRYGLSVVVRYKDDNYDPLQSYSYGVKLLIQEADAFPSAHSAAKFIAFNSETFAAVRP-QETFC 311
            |:..|||:.:|.:.:::.||.|...|.::::...|. |         ||..:....||| .||..
Mouse   351 GVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDE-P---------AFMDDGGFNVRPGVETSI 405

  Fly   312 SSAVKALIIEERN---CVFQ-NEFPMR--YFSDYVYPNCELNCRVTNMVKFCGCHTYFF------ 364
            |...:||.....|   |... ::.|::  |.|.|....|..:|...||:|.|||...|:
Mouse   406 SMRKEALDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGV 470

  Fly   365 ---DFNRTS---------------DRICTFRDI--PCLVDNFGRLLLICSKYSDFNRLLSANIIT 409
               |:.:.|               |.:..|...  ||.|.|:    .:.:.||.:..:.|.:.|.
Mouse   471 EFCDYLKQSSWGYCYYKLQAAFSLDSLGCFSKCRKPCSVTNY----KLSAGYSRWPSVKSQDWIF 531

  Fly   410 RKKSTQCYCPLTCEHIDYDVQLTNFPLELNMPVADKFYSGLAKNDGVLHVFINSFSYRRLRRDLL 474
            ...|                      |:.|..:.:| .:|:||    |::|....:|:.......
Mouse   532 EMLS----------------------LQNNYTINNK-RNGVAK----LNIFFKELNYKTNSESPS 569

  Fly   475 SNMVTLVSNLGSAFSLFVGMSMLSVV---EIIYYFSVILRKNYKLECETRSQMLHKKPKFAW 533
            ..||:|:|||||.:||:.|.|:||||   |:|:...||          |...:||:.....|
Mouse   570 VTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVI----------TLIMLLHRFRSRYW 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	None
Scnn1a	NP_035454.2	ENaC	80..677	CDD:273304	134/630 (21%)
		deg-1	88..600	CDD:273309	125/589 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842200
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850