DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nach and asic-2

DIOPT Version :9

Sequence 1:	NP_001334724.1	Gene:	Nach / 36864	FlyBaseID:	FBgn0024319	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_492099.1	Gene:	asic-2 / 189058	WormBaseID:	WBGene00012137	Length:	545	Species:	Caenorhabditis elegans

Alignment Length:	555	Identity:	111/555 - (20%)
Similarity:	191/555 - (34%)	Gaps:	172/555 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 WSDFCATSSIHGLKYTRDEDTNKIVHLVWLLISVVMFICA-------VVMARTFYMDYRSSPTRM 84
            :.||...|::..:.:..:.: |||..:.|  |::.:|:..       :::|:.|     |.|..:
Worm    10 FKDFSNWSTVAVVPHVANAN-NKISRIFW--IAIFLFVLGMFAYELYILIAKFF-----SYPATV 66

  Fly    85 NVESDNTPVNRLYFPPVTIC---PDVLFNMQKSEAF--LNTLRLPKGAELRGILRKLHIFYGFML 144
            |.|   ....:..||.||:|   |.....::.:.||  :|||.........|......  :|...
Worm    67 NTE---ILFEKQIFPVVTVCNMNPYKYSVVKSNSAFSSVNTLMTTYSDATVGTFSTDK--WGLYA 126

  Fly   145 D-DERYS----AEDIEQMEALLFLNNLTIPEFVEHLRWNCDEILYRCRFNGEIMDCSK--IFQLS 202
            | ||.|.    |.|...:||.|..:...:|....:.     :::..|.|.|  :.||:  ..:..
Worm   127 DNDETYDLDSRAADALVLEANLISDTAKVPALYTYA-----DLIQDCSFAG--IPCSESDFTKFI 184

  Fly   203 KTFFGHCCSFNLRQKGWVNNKLNNLESFKVFHLNSLNFTAQRAIGGLRYGLSVVVRYKDDNYDPL 267
            ...:|.|.|||                    ...|||::..|.  |:::||.:::..       .
Worm   185 DPVYGACYSFN--------------------EDASLNYSVSRE--GIQFGLKLMLTV-------T 220

  Fly   268 QSYSYGVKLLIQEADAFPSAHSAAKFIAFNS---------------------------ETFAAVR 305
            |:.:.|      ..|:.|:...|...|..||                           :...|.:
Worm   221 QTKTNG------NTDSLPTTKLAGARIGVNSRGSSPGLDSNGIDAGVGYESAVSVSLTQNVRAKK 279

  Fly   306 PQETFCSSAVKALIIEERNCVFQNEFPMRYFSDYVY--PNCELNCRVTNMVKFCGCHTYFFDFNR 368
            |..|               ||.:......|:.|::|  ..|...|:..:.:..|.|.........
Worm   280 PYGT---------------CVDREPDSSDYYKDFIYTLETCFNGCKQRDTIAKCQCANPRLALGS 329

  Fly   369 TSDRIC--TFRDIPCLVDNFGRLLLICSKYSDFNRLLSANIITRKKST-------QCYCPLTCEH 424
            | |..|  ...|:.||                  :.|..|   :..||       :|.|...|:.
Worm   330 T-DTACQPIKADLDCL------------------QTLKGN---QTSSTPNIDLLVECNCNPPCDE 372

  Fly   425 IDY--DVQLTNFPLELNMPVADKFYSGLA-------------------KNDG-VLHVFINSFSYR 467
            ..|  .|.|..|| ..:..||....:|:.                   .|:| ::.||:.:.||.
Worm   373 STYTPTVSLAQFP-STSYYVATSSTAGVGSCSSTNSKFSSKSDCQKWYNNNGMIIQVFLETLSYE 436

  Fly   468 RLRRDLLSNMVTLVSNLGSAFSLFVGMSMLSVVEI 502
            .........:..::::||....|::|:|::||||:
Worm   437 LYTETAGYTVSNVINDLGGQAGLWLGLSVISVVEM 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	None
asic-2	NP_492099.1	deg-1	12..474	CDD:273309	111/553 (20%)
asic-2	NP_492099.1	ASC	13..471	CDD:279230	109/550 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820