DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nach and del-4

DIOPT Version :9

Sequence 1:	NP_001334724.1	Gene:	Nach / 36864	FlyBaseID:	FBgn0024319	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_492230.2	Gene:	del-4 / 189033	WormBaseID:	WBGene00012116	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	580	Identity:	122/580 - (21%)
Similarity:	209/580 - (36%)	Gaps:	138/580 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LRRTWSDFCATSSIHGLKYTRDEDTNKIVHLVWLL---ISVVMFICAVVMARTFYMDYRSSPTRM 84
            |:..::||...:|.||:.:....:. :.:...|:|   :|:.:||...:...|.|:.:     .:
Worm     8 LKYVFTDFSCWTSTHGVPHIGMANA-RWLRAFWILVVVVSIALFIWQFITLLTNYLSF-----SV 66

  Fly    85 NVESDNTPVNRLYFPPVTIC--------------PDV--LFNMQKSEAFLNTLRLPKG--AELRG 131
            |.|:......|. ||.||||              ||:  |.:...|::......||..  |:.:.
Worm    67 NTETTLQFAERT-FPTVTICHLNPWKLSETKSVDPDMSALIDAYNSDSSSAQFGLPASLTADRQQ 130

  Fly   132 ILRKLHIFYGFMLDDERYS-AEDIEQMEALLFLNNLTIPEFVEHLRWNCDEILYRCRFNGEIMDC 195
            ...|..:.|...|::::|: |.||                     .::.|:::..|.:|.:..:.
Worm   131 QASKWTLMYSERLNEKQYNDAADI---------------------AYSYDDMVVSCTYNAKTCNI 174

  Fly   196 SKIFQLSKTFFGHCCSFNLRQKGWVNNKLNNLESFKVFHLNSLNFTAQRAIGGLRYGLSVVVRYK 260
            :.........:|:|..||                      ....:::.||  |..|||.:|:|..
Worm   175 TDFNDFYNPSYGNCLQFN----------------------TDGMYSSSRA--GPLYGLRMVMRTD 215

  Fly   261 DDNYDPLQSYSYGVKLLIQEADAFPSAHSAAKFIAFNSETFAAVRPQETFCSSAVK-----ALII 320
            .|.|.|....| ||.:.|...|..|           ..:.|....|..|..|..|.     .|..
Worm   216 QDTYLPWTEAS-GVIIDIHMQDEIP-----------YPDVFGYFAPPGTASSLGVSYVQTTRLSK 268

  Fly   321 EERNCVFQNEF-PMRYFSDYVYPNCELNCRVTNMVKFCGCH--TYFFDFNRTSDRIC-----TFR 377
            ...:|..:.:. ...|...|....|..:|....::..|||:  .|....|.|....|     |..
Worm   269 PYGSCTTKTKLKTTHYTGTYTVEACFRSCMQEKIIASCGCYYPAYSHASNTTQYVSCDNGVQTLS 333

  Fly   378 DIPCLVDNFGRLLLICSKYSDFNRLLSANIITRKKSTQCYCPLTCEHIDYDVQLTN--------F 434
            ::.| ||     |:..:..::|:.|           |.|.||..||...|.|.::.        .
Worm   334 NLNC-VD-----LINSADSTEFDVL-----------TDCDCPQPCEIDSYGVTVSTAQWPSDSYV 381

  Fly   435 PLELNM--PVADKFYSG------LAKNDGVLHVFINSFSYRRLRRDLLSNMVTLVSNLGSAFSLF 491
            |.|.|.  |......||      ...|..::.::....:::.|........|..:|::|....||
Worm   382 PTECNPGGPSGPWDASGESCLDWYKANTILIEIYYERMNFQVLTESPAYTFVNFISDVGGQVGLF 446

  Fly   492 VGMSMLSVVE-----IIYYFSVILRKNYKLECETRSQMLHKKPKFAWPKANDTHSKEQKS 546
            :|||::|.:|     .:.:|.....|:.:.|.| :.:|..||.|....:..:...|.||:
Worm   447 LGMSIISAIEYLVLIFLVFFYCCTHKSRRAEIE-QLEMDIKKAKDDVDQVAEKRKKHQKA 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	None
del-4	NP_492230.2	ASC	8..466	CDD:295594	111/538 (21%)
del-4	NP_492230.2	deg-1	14..460	CDD:273309	110/526 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820