DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nach and acd-1

DIOPT Version :9

Sequence 1:	NP_001334724.1	Gene:	Nach / 36864	FlyBaseID:	FBgn0024319	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_491295.2	Gene:	acd-1 / 182852	WormBaseID:	WBGene00016064	Length:	635	Species:	Caenorhabditis elegans

Alignment Length:	578	Identity:	115/578 - (19%)
Similarity:	208/578 - (35%)	Gaps:	155/578 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LRRTWSDFCATSSIHGLKYTRDEDTNKIVHLVWLLISVVMFICA--VVMARTFYM--DYRSSPTR 83
            ::|....||.|:::||.|  |.....:...|.||    :|..|:  :::.:.|.:  :|.|.||
Worm    76 IKRETQHFCETTTMHGPK--RIFQGKRWATLFWL----IMVSCSLGLLITQVFILASEYLSKPT- 133

  Fly    84 MNVESDNTPVNR--LYFPPVTIC--------------------PDVLFNMQKSEAFLNTL----- 121
              |...:..:|.  :.||.:|||                    |.::..|.|....:.||
Worm   134 --VSDVSFLINEDGMDFPLITICNLNPIRKTYVNEINKTGEVSPPMINYMMKWFTEIPTLIGGAD 196

  Fly   122 --RLPKGAELRGILRKLHIFYGFMLDDERYSAEDIEQMEALLFLNNLTIPEFVEHLRWNCDEILY 184
              .|.:|.|...:..|.|:                          |.|:..|..:..::|.:|..
Worm   197 RPTLHEGNEELKLYMKNHL--------------------------NFTVDSFFMNSGFSCPDIFK 235

  Fly   185 RCRFNGEIMDCSKIFQLSKTFFGHCCSFNLRQKGWVNNKLNNLESFKVFHLNSLNFTAQRAIGGL 249
            .|.|.|||.||..:.....|..|.|.:.:|.            .|.|.    |::   ::...|:
Worm   236 LCSFQGEIFDCCTLSTEVLTPLGKCFTLDLS------------SSTKA----SMH---KQTEPGI 281

  Fly   250 RYGLSVVV-RYKDDNYDP--------LQSYSYGVKLLIQEADAFPSAHSAAKFIAFNSETFAAVR 305
            :.||::.: .:.::.:|.        ..|:..|.:..:...:..|...|....::.|:..|:|:
Worm   282 QAGLAITLDAHLEEQFDGSNGMDALFTNSFVNGFRYFVHPPNTIPHLSSDEFTVSPNTVAFSAI- 345

  Fly   306 PQETFCSSAVKALIIEER--NCVFQNEFPMRYFSDYVYP--NCELNCRVTNMVKFCGCHTYFFDF 366
                  ||....|:...:  ||.  ..||....|:..|.  ||...|:....::.|||....::.
Worm   346 ------SSDRYVLLPTHQWGNCT--ENFPDGIQSNLSYSSGNCLSLCKAKFYMENCGCTPALYNI 402

  Fly   367 NRTSDRICTFRDIPCLVDNFGRLLLICSKYSDFNRLLSANIITRK---KSTQC-YCPLTCEHI-- 425
            .........:....|| ||.               |...|..|.|   ::..| .|...|..:
Worm   403 ENNLKECTPYETTTCL-DNI---------------LAKPNKETGKIEFQTPNCKACAQQCNSLVY 451

  Fly   426 ----DYDVQLTNFPLELNMPVADKFYSG-LAKNDGVLHVFINSFSYRRLRRDLLSNMVTLVSNLG 485
                .|..|.:.........:..::..| :..|..::::|....||....:...:::..|:|::|
Worm   452 RAYNSYGSQFSAGAFHYLKSINPEWTDGHMRANFQMINIFYRDMSYTEYNQVQDASVTQLLSDIG 516

  Fly   486 SAFSLFVGMSMLSVVEIIYYFSVIL-------RKNYKLE------------CETRSQM 524
            ....:|:|||::::.||..:||.:.       |::|...            |||..:|
Worm   517 GNMGMFLGMSVITITEICLFFSKMFWLGFSKKRRDYMYSKRVNEKTHEREVCETVEKM 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	None
acd-1	NP_491295.2	ASC	83..536	CDD:279230	106/531 (20%)
acd-1	NP_491295.2	deg-1	83..536	CDD:273309	106/531 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162300
Domainoid	1	1.000	94	1.000	Domainoid score	I4697
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14160
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.850