Protein Alignment Nach and Asic2

DIOPT Version :10

• Sequence 1: NP_001334724.1
• Gene: Nach / 36864
• FlyBaseID: FBgn0024319
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: XP_006532059.1
• Gene: Asic2 / 11418
• MGIID: 1100867
• Length: 596
• Species: Mus musculus
• Alignment Length: 571
• Identity: 103/571 - (18%)
• Similarity: 190/571 - (33%)
• Gaps: 188/571 - (32%)

  Fly    31 CATSSIHGLKYTRDEDTNKIVHLVWLLISVVMFICAVVMARTFYMDYRSSPTRMNVESDNTPVNR 95
            ||..:..|..:.|        ..:|:|.........:..:....:.:.|.|:...|..:.:  .:
Mouse    73 CAGRTAAGGSFQR--------RALWVLAFCTSLGLLLSWSSNRLLYWLSFPSHTRVHREWS--RQ 127

  Fly    96 LYFPPVTICPDVLFNMQKSEAFLNTLRLPKGAELRGILRKLHIFY-----GFML----------- 144
            |.||.||:|.:            |.||.|:       |.|..::|     |.:|
Mouse   128 LPFPAVTVCNN------------NPLRFPR-------LSKGDLYYAGHWLGLLLPNRTARPLVSE 173

  Fly   145 ----DDERYSAEDIEQMEALLFLNNLTIP---------EFVEHLRWNCDEILYRCRFNGEI---- 192
                |:.|      .|....|....|.:|         .|::.|....:::|..|::.||:
Mouse   174 LLRGDEPR------RQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELCGPH 232

  Fly   193 ----MDC----------------------------SKIFQLSKTFFGHCCSFNLRQKGWVNNKLN 225
                :.|                            :.:|    |.:|.|..||..:.|
Mouse   233 NFSSVSCPPREPALSDPALPRSPEALRWAPGTGHQAPVF----TKYGKCYMFNSGEDG------- 286

  Fly   226 NLESFKVFHLNSLNFTAQRAIGGLRYGLSVVVRYKDDNYDPL------QSYSYGVKLLIQEADAF 284
                      ..|..|.:   ||...||.:::..:.|.|.|:      .::..|||:.|......
Mouse   287 ----------KPLLTTVK---GGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEP 338

  Fly   285 PSAHSAAKFIAFNSETFAAVRPQE-TF-------CSSAVKALIIEERNCVFQNEFPMRYFSDYVY 341
            |........:|...:||.|.:.|. |:       |.|               :|..:.:|..|..
Mouse   339 PFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRS---------------SEMGLDFFPVYSI 388

  Fly   342 PNCELNCRVTNMVKFCGCHTYFFDFNRTSDRICTFRDIP-CLVDNFGRLLLICSKYSDFNRLLSA 405
            ..|.::|....:|:.|.|......           .|.| |..:....    |::       .:.
Mouse   389 TACRIDCETRYIVENCNCRMVHMP-----------GDAPFCTPEQHKE----CAE-------PAL 431

  Fly   406 NIITRKKSTQCYCPLTCEHIDYDVQLT--NFP-------LELNMPVADKFYSGLAKNDGVLHVFI 461
            .::..|.|..|.|...|....|:.:|:  ..|       ||.....::|:   :::|..||.:|.
Mouse   432 GLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKY---ISENILVLDIFF 493

  Fly   462 NSFSYRRLRRDLLSNMVTLVSNLGSAFSLFVGMSMLSVVEIIYYFSVILRK 512
            .:.:|..:.:.....:..|:.::|....||:|.|:|:::|:..|...::::
Mouse   494 EALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKE 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	ASC	30..505	CDD:459966	102/562 (18%)
Asic2	XP_006532059.1	ENaC	64..590	CDD:273304	103/571 (18%)