DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nach and asic5

DIOPT Version :9

Sequence 1:	NP_001334724.1	Gene:	Nach / 36864	FlyBaseID:	FBgn0024319	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_017951381.2	Gene:	asic5 / 100498195	XenbaseID:	XB-GENE-983430	Length:	852	Species:	Xenopus tropicalis

Alignment Length:	512	Identity:	112/512 - (21%)
Similarity:	199/512 - (38%)	Gaps:	118/512 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 FCATSSIHGLKYTRDE----DTNKIVHLVWLLISVVMFICAVVMARTFYMDYRSSPTRMNVESDN 90
            |..::|.||:....:.    ..:|....:|..:..|..|.|.....|..::|.|.||..:|....
Frog   387 FATSTSFHGVHNLVENGGSGKNSKFRTAIWTSVVSVFIIMACWQVCTRVINYFSWPTTTSVNVQY 451

  Fly    91 TPVNRLYFPPVTICPDVLFNMQKSEA-FLNTLRLPKGAELRGILRKLHIFYGFMLDDERYSAEDI 154
              |..:.||.:|.|     |:.:.:. .:|.|.:  ...|..|:..:..|.....|     ..::
Frog   452 --VENIDFPAITFC-----NLNRFQTKAVNNLSI--AFFLWNIVSAVLHFTSIASD-----PGEM 502

  Fly   155 EQMEALLFLN-NLTIPEFVEHLRWNC-DEILYRCRFNGEIM---DCSKIFQLSKTFFGHCCSFNL 214
            :::...|.|| |.:|.||.::..:.. :..|.:|.|.|...   |...||    |.:|:|.:||.
Frog   503 QEVTDFLKLNKNFSIKEFTKNYGFYLNNSTLLKCSFFGYPCYPEDFEHIF----TEYGNCYTFNY 563

  Fly   215 RQKGWVNNKLNNL-ESFKV-FHLNSLNFTAQRAIGGLRYGLSVVVRYKDDNYDPLQSYSY-GVKL 276
            .... :|.::... ....| |.:....||.:.::|.:..|:|.|:      :.||....: |:.|
Frog   564 NTVS-MNKRITTAGRGLSVLFDIKQTEFTDEPSLGFVDAGISFVL------HSPLVPPRFDGLGL 621

  Fly   277 LIQEADAFPSAHSAAKFIAFNS-ETFAAVRPQETF--CSSAVKALIIEERNCVFQNEFPMRYFSD 338
                       ||.|...|..| ..|..|..:..:  |:.::|                ::|...
Frog   622 -----------HSPAGMHAHVSMRRFKTVIQEHPWGECNPSLK----------------LKYHEI 659

  Fly   339 YVYPNCELNCRVTNMVKFCGCHTYFFDFNRTSDRICTFRDIPCLVDNFGRLLLICSKYSDFNRL- 402
            |....|...|:...:...|||                   ||.|:...|       |..|..:|
Frog   660 YSTYGCLQECKSYYIQNECGC-------------------IPFLLPGNG-------KECDLQQLY 698

  Fly   403 --LSANIITRKKSTQC-------YCPLTCEHIDY--DVQLTNFPLELNMPVADKFYSG-LAKN-- 453
              :|..:.|.:||..|       .||:.||..|:  .:..:.||.:    .|.:|.|. |:|:
Frog   699 NCVSRALYTIEKSELCSMGTYNSTCPVPCEETDFPATISYSTFPSD----KAAQFLSAKLSKSAL 759

  Fly   454 ---DGVLHVFI--NSFSYRRLRRDLLSNMVTLVSNLGSAFSLFVGMSMLSVVEIIYY 505
               :.::::.|  :..:|:.:::........|:||:|....||.|.||::::|::.|
Frog   760 YMRNNLVYIDIKYHEMNYKIMKQQKALTASELLSNIGGQLGLFCGASMITIIEVLEY 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nach	NP_001334724.1	None
asic5	XP_017951381.2	Inhibitor_I29	66..129	CDD:400519
		Peptidase_C1A	158..360	CDD:239068
		ASC	387..816	CDD:395688	111/510 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010