Protein Alignment Amyrel and SLC3A1

DIOPT Version :10

• Sequence 1: NP_477262.1
• Gene: Amyrel / 36863
• FlyBaseID: FBgn0020506
• Length: 493
• Species: Drosophila melanogaster
• Sequence 2: NP_000332.2
• Gene: SLC3A1 / 6519
• HGNCID: 11025
• Length: 685
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 102/602 - (16%)
• Similarity: 189/602 - (31%)
• Gaps: 223/602 - (37%)

  Fly     4 FALTLT---LCLAGSLSLAQHNP---HWWGNRNTIVHLFEWKWSDIAQECESFLGPRGFAGVQVS 62
            |.||:.   :.:|.::::...:|   .|| ....:..::...:.|..::     |.....|:|..
Human    90 FWLTVASVLVLIAATIAIIALSPKCLDWW-QEGPMYQIYPRSFKDSNKD-----GNGDLKGIQDK 148

  Fly    63 PVNENILSAGRPWWERYQPISYKLTTRS---------------GNEEEFGDMVRRCNDVGVRIYV 112
            ......|:....|...:    ||.:.:.               |..|:|.::|...:|.|:::.:
Human   149 LDYITALNIKTVWITSF----YKSSLKDFRYGVEDFREVDPIFGTMEDFENLVAAIHDKGLKLII 209

  Fly   113 DVLLNHMSGDFDGVAVGTAGTEAEPSKKSFPGVPYTAQDFH--------PTCEITD---WND--- 163
            |.:.||.|                              |.|        .|.:.||   |:|
Human   210 DFIPNHTS------------------------------DKHIWFQLSRTRTGKYTDYYIWHDCTH 244

  Fly   164 --------------------------------RFQVQQCELVGLKDLDQSSDWVRSKLIEFLDHL 196
                                            :|..:|      .||:..:..|:.::.|.|...
Human   245 ENGKTIPPNNWLSVYGNSSWHFDEVRNQCYFHQFMKEQ------PDLNFRNPDVQEEIKEILRFW 303

  Fly   197 IELGVAGFRVDA------AKHMASE-------------DLEYIYSSLSNLNID-HGFPHNSRPFI 241
            :..||.||.:||      |||:..|             ....:|...:...:. |....:.|..:
Human   304 LTKGVDGFSLDAVKFLLEAKHLRDEIQVNKTQIPDTVTQYSELYHDFTTTQVGMHDIVRSFRQTM 368

  Fly   242 FQEVIDHGH----------ETVSRD-EYKDLGAVTE--FRFSEEIG--NAFRGNNALKWLQSWGT 291
            .|...:.|.          |::.|. .|..|..:.|  |.|:..:.  :...||:..:.:.||..
Human   369 DQYSTEPGRYRFMGTEAYAESIDRTVMYYGLPFIQEADFPFNNYLSMLDTVSGNSVYEVITSWME 433

  Fly   292 DWGFLPSGQALTF-VDNHDNQRDAGAVLNYKSPRQYKMATAFHLAYPYGISRVMSSFAFDDHDTP 355
            :   :|.|:...: :...|:.|     |..:...||              ..||:...|....||
Human   434 N---MPEGKWPNWMIGGPDSSR-----LTSRLGNQY--------------VNVMNMLLFTLPGTP 476

  Fly   356 PPQDAQE----RIISPEFDADGACVNGWICEHRWRQIYAMVGFKNAVRDTEITGWWDNGDNQISF 416
            .....:|    .|::...:                :.|.:    |.:| ::....|||..| ..|
Human   477 ITYYGEEIGMGNIVAANLN----------------ESYDI----NTLR-SKSPMQWDNSSN-AGF 519

  Fly   417 CRGNKGFLAINNNLYDLSQDLNTCLPAGT---YCDVISGSLIDGSCTGKSVTVNE---NGYGYIH 475
            ...:..:|..|::.:.::.|:....|...   |.|:   ||:.         .||   |...:.|
Human   520 SEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDL---SLLH---------ANELLLNRGWFCH 572

  Fly   476 IGSD--------DFDGV 484
            :.:|        :.||:
Human   573 LRNDSHYVVYTRELDGI 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Amyrel	NP_477262.1	AmyAc_bac_euk_AmyA	29..398	CDD:200456	74/469 (16%)
		Aamy_C	404..492	CDD:214749	20/95 (21%)
SLC3A1	NP_000332.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56
		AmyAc_SLC3A1	116..569	CDD:200494	93/554 (17%)