DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Amyrel and amy2b

DIOPT Version :9

Sequence 1:	NP_477262.1	Gene:	Amyrel / 36863	FlyBaseID:	FBgn0020506	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_001007948.1	Gene:	amy2b / 493323	XenbaseID:	XB-GENE-5725537	Length:	512	Species:	Xenopus tropicalis

Alignment Length:	516	Identity:	243/516 - (47%)
Similarity:	325/516 - (62%)	Gaps:	35/516 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FALTLTLCLAGSLSLAQHNPHWWGNRNTIVHLFEWKWSDIAQECESFLGPRGFAGVQVSPVNEN- 67
            |.:.:.||      ..|::|:....:.:|||||||||.|||.|||.:|||.||.|||:||.|||
Frog     6 FLVVIKLC------SGQYDPNVKPGKTSIVHLFEWKWEDIADECERYLGPNGFGGVQISPPNENL 64

  Fly    68 -ILSAGRPWWERYQPISYKLTTRSGNEEEFGDMVRRCNDVGVRIYVDVLLNHMSGDFDGVAVG-- 129
             |....|||.|||||:||:|.|||||||:|.|||.|||:.||.||||.::|||:|  .|..:|
Frog    65 VITKPWRPWDERYQPVSYQLCTRSGNEEQFIDMVTRCNNAGVHIYVDTVINHMTG--YGAGIGNS 127

  Fly   130 -TAGTEAEPSKKSFPGVPYTAQDF-HPTCE-----ITDWNDRFQVQQCELVGLKDLDQSSDWVRS 187
             |.|:......:.||.|||:..|| :..|:     |.::||.:||:.|:|:||.||....|:||.
Frog   128 STCGSYFNSGARDFPAVPYSFLDFSNYKCKSHSGGIENYNDPYQVRDCQLLGLLDLALEKDYVRE 192

  Fly   188 KLIEFLDHLIELGVAGFRVDAAKHMASEDLEYIYSSLSNLNIDHGFPHNSRPFIFQEVIDHGHET 252
            |:.|::::||.:||||||:||:|||...|::.|.:.|.:||.. .|.:.:|||::|||||.|.|.
Frog   193 KIAEYMNNLINIGVAGFRLDASKHMWPGDIKAILNRLEDLNTT-WFSNGTRPFVYQEVIDLGGEA 256

  Fly   253 VSRDEYKDLGAVTEFRFSEEIGNAFRGNNALK--WLQSWGTDWGFLPSGQALTFVDNHDNQRDAG 315
            :|..:|...|.||||::..::|...|..|..|  :|::||..|||:||.:||.|||||||||..|
Frog   257 ISASDYFGTGRVTEFKYGAKLGTVIRRWNGEKMAYLRNWGEGWGFMPSDRALVFVDNHDNQRGHG 321

  Fly   316 A----VLNYKSPRQYKMATAFHLAYPYGISRVMSSFAFDDHDTP---------PPQDAQERIISP 367
            |    :|.:...:.||||..|..|:|||.:|||||:.:..|...         ||.:........
Frog   322 AGGSSILTFFESQLYKMAVGFMHAHPYGFTRVMSSYRWPRHFADGKDINNWMGPPSNPDGSTQPV 386

  Fly   368 EFDADGACVNGWICEHRWRQIYAMVGFKNAVRDTEITGWWDNGDNQISFCRGNKGFLAINNNLYD 432
            ...||..|.|.|:||||||||..||.|:|.|....:|.|||||:|||:|.||||||:..||:.:|
Frog   387 TIKADTTCGNNWVCEHRWRQIKNMVIFRNVVDGQALTNWWDNGNNQIAFGRGNKGFIVFNNDDWD 451

  Fly   433 LSQDLNTCLPAGTYCDVISGSLIDGSCTGKSVTVNENGYGYIHIGSDDFDGVLALHVDAKV 493
            |...|||.||||||||||||...|..|:||.:|||::...:..|.:...|..:|:||:||:
Frog   452 LDVTLNTGLPAGTYCDVISGQKQDTMCSGKKITVNKDSTAHFQISNTAEDPFVAIHVNAKL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amyrel	NP_477262.1	AmyAc_bac_euk_AmyA	29..398	CDD:200456	188/394 (48%)
Amyrel	NP_477262.1	Aamy_C	404..492	CDD:214749	47/87 (54%)
amy2b	NP_001007948.1	AmyAc_bac_euk_AmyA	25..417	CDD:200456	188/394 (48%)
amy2b	NP_001007948.1	Aamy_C	423..511	CDD:214749	47/87 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	264	1.000	Domainoid score	I1877
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	567	1.000	Inparanoid score	I1058
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D231864at33208
OrthoFinder	1	1.000	-	-		FOG0000926
OrthoInspector	1	1.000	-	-		mtm9418
Panther	1	1.100	-	-	O	PTHR43447
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X338
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160