DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Amyrel and amy2al2

DIOPT Version :9

Sequence 1:	NP_477262.1	Gene:	Amyrel / 36863	FlyBaseID:	FBgn0020506	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_001003729.1	Gene:	amy2al2 / 445049	ZFINID:	ZDB-GENE-040801-179	Length:	512	Species:	Danio rerio

Alignment Length:	512	Identity:	241/512 - (47%)
Similarity:	320/512 - (62%)	Gaps:	25/512 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LTLTLCLAGSLSLAQHNPHWWGNRNTIVHLFEWKWSDIAQECESFLGPRGFAGVQVSPVNENI-- 68
            :.|.|.....|..|||||:....|.:|||||||:|:|||:|||.:|.|.|:.|||:||.:|::
Zfish     2 MLLVLVAIFGLGFAQHNPNTKNGRTSIVHLFEWRWADIAEECERYLAPNGYGGVQISPPSEHVKL 66

  Fly    69 LSAGRPWWERYQPISYKLTTRSGNEEEFGDMVRRCNDVGVRIYVDVLLNHMSGDFDGVAV-GTAG 132
            .:...|||:|||||||.|.:|||.|.|..||:.|||:|||.||.||::|||.....|... .:.|
Zfish    67 TNPWHPWWQRYQPISYNLCSRSGTEAELKDMITRCNNVGVNIYADVVINHMCKSIHGAGTPSSCG 131

  Fly   133 TEAEPSKKSFPGVPYTAQDFHP-TC-----EITDWNDRFQVQQCELVGLKDLDQSSDWVRSKLIE 191
            :..:.:|:.||.|||:..||:. .|     :|..:||.:||:.|.|..|.||....|:||.|:.|
Zfish   132 SHFDANKEDFPTVPYSYLDFNDGKCKSASGQIESYNDIYQVRDCRLEDLLDLALEKDYVRGKVAE 196

  Fly   192 FLDHLIELGVAGFRVDAAKHMASEDLEYIYSSLSNLNIDHGFPHNSRPFIFQEVIDHGHETVSRD 256
            :|:.|||||||||||||.|||...||..:||.|..|| ...||..::|||:|||||.|.|.:...
Zfish   197 YLNKLIELGVAGFRVDACKHMWPGDLSNVYSRLKTLN-TKWFPSGTKPFIYQEVIDLGGEPIKAS 260

  Fly   257 EYKDLGAVTEFRFSEEIGNAFR--GNNALKWLQSWGTDWGFLPSGQALTFVDNHDNQRDAGA--- 316
            ||..|..||||:.|.:||.|.|  ....|.:|::||..|||:||.:||.|||||||||..||
Zfish   261 EYYGLARVTEFKHSAKIGTAVRKWDGEKLSYLKNWGEGWGFMPSDKALVFVDNHDNQRGHGAGGA 325

  Fly   317 -VLNYKSPRQYKMATAFHLAYPYGISRVMSSFAF--------DDHDTPPPQDAQERIISP-EFDA 371
             ||.:...|.||||..|.||:|||::|||||:.:        |::|...|....:....| ..:.
Zfish   326 SVLTFWDSRLYKMAAGFMLAHPYGVTRVMSSYQWDRKIVNGKDENDWMGPPSFSDGSTKPVPINP 390

  Fly   372 DGACVNGWICEHRWRQIYAMVGFKNAVRDTEITGWWDNGDNQISFCRGNKGFLAINNNLYDLSQD 436
            |..|.:||:||||||||..||.|:|.|....:..|||||::||:|.||:|||:.|||:.::|:..
Zfish   391 DSTCGDGWVCEHRWRQIRNMVIFRNVVNGQPLFNWWDNGNSQIAFSRGSKGFIVINNDNWELNAT 455

  Fly   437 LNTCLPAGTYCDVISGSLIDGSCTGKSVTVNENGYGYIHIGSDDFDGVLALHVDAKV 493
            |||.|.:|||||:|||.....|||||.|:|:.:|.....|...:.|..:|:|.|:|:
Zfish   456 LNTGLQSGTYCDIISGEKSGNSCTGKQVSVDSDGKATFSISHTEEDPFMAIHADSKL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amyrel	NP_477262.1	AmyAc_bac_euk_AmyA	29..398	CDD:200456	189/392 (48%)
Amyrel	NP_477262.1	Aamy_C	404..492	CDD:214749	42/87 (48%)
amy2al2	NP_001003729.1	AmyAc_bac_euk_AmyA	25..417	CDD:200456	189/392 (48%)
amy2al2	NP_001003729.1	Aamy_C	424..511	CDD:214749	42/86 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576493
Domainoid	1	1.000	269	1.000	Domainoid score	I1797
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	577	1.000	Inparanoid score	I1002
OMA	1	1.010	-	-		QHG53143
OrthoDB	1	1.010	-	-		D231864at33208
OrthoFinder	1	1.000	-	-		FOG0000926
OrthoInspector	1	1.000	-	-		mtm6522
orthoMCL	1	0.900	-	-		OOG6_103366
Panther	1	1.100	-	-	O	PTHR43447
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X338
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.770