DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Amyrel and amy2a

DIOPT Version :9

Sequence 1:	NP_477262.1	Gene:	Amyrel / 36863	FlyBaseID:	FBgn0020506	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_998176.2	Gene:	amy2a / 406539	ZFINID:	ZDB-GENE-040426-2393	Length:	512	Species:	Danio rerio

Alignment Length:	514	Identity:	245/514 - (47%)
Similarity:	324/514 - (63%)	Gaps:	30/514 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LTLTLCLAGSLSLAQHNPHWWGNRNTIVHLFEWKWSDIAQECESFLGPRGFAGVQVSPVNENIL- 69
            |.:...|.| |||||.:|:....|..|||||||:|:|||.|||.:|||.||.|||:||.:|:|:
Zfish     3 LLILAALVG-LSLAQFDPNTKSGRTAIVHLFEWRWADIAAECERYLGPNGFGGVQISPPSESIVV 66

  Fly    70 -SAGRPWWERYQPISYKLTTRSGNEEEFGDMVRRCNDVGVRIYVDVLLNHMSGDFDGVAV-GTAG 132
             :...|||:|||||.|.|.:|||||.|..||:.|||:|||.||||.::|||.|...|... .:.|
Zfish    67 TNPWHPWWQRYQPIGYNLCSRSGNENELKDMITRCNNVGVNIYVDAVINHMCGSGGGSGTHSSCG 131

  Fly   133 TEAEPSKKSFPGVPYTAQDFHP-TC-----EITDWNDRFQVQQCELVGLKDLDQSSDWVRSKLIE 191
            :....:.|.||.|||:..||:. .|     .|.::.|..||:.|.||||.||....|:||||:.:
Zfish   132 SYFNANNKDFPTVPYSNLDFNDGKCNTGSGNIENYQDINQVRNCRLVGLLDLALEKDYVRSKVAD 196

  Fly   192 FLDHLIELGVAGFRVDAAKHMASEDLEYIYSSLSNLNIDHGFPHNSRPFIFQEVIDHGHETVSRD 256
            :::.||::|||||||||.|||...||..:|..|.||| ...||..::|||||||||.|.|.::..
Zfish   197 YMNKLIDMGVAGFRVDACKHMWPGDLSAVYGRLHNLN-TRWFPSGAKPFIFQEVIDLGGEPITSS 260

  Fly   257 EYKDLGAVTEFRFSEEIGNAFRGNNA--LKWLQSWGTDWGFLPSGQALTFVDNHDNQRDAGA--- 316
            ||..:|.||||::..::||..|..|.  |.:|::||..|||:||.:||.|||||||||..||
Zfish   261 EYTGIGRVTEFKYGAKLGNIIRKWNGEKLSYLKNWGEGWGFMPSDKALVFVDNHDNQRGHGAGGA 325

  Fly   317 -VLNYKSPRQYKMATAFHLAYPYGISRVMSSFAFDDHDTPPPQDAQERIISPEFDADGA------ 374
             ::.:...|.||||..|.||:|||.:|||||:.: |.:....|| |...|.|..:.||:
Zfish   326 SIVTFWDARLYKMAVGFMLAHPYGFTRVMSSYRW-DRNIVNGQD-QNDWIGPPSNGDGSTKPVPI 388

  Fly   375 -----CVNGWICEHRWRQIYAMVGFKNAVRDTEITGWWDNGDNQISFCRGNKGFLAINNNLYDLS 434
                 |.:.|:||||||||..||.|:|.|.....:.|||||.|||:|.||::||:.|||:.::|:
Zfish   389 NPDSTCGDNWVCEHRWRQIKNMVIFRNVVNGQPFSNWWDNGSNQIAFSRGSRGFIIINNDDWELN 453

  Fly   435 QDLNTCLPAGTYCDVISGSLIDGSCTGKSVTVNENGYGYIHIGSDDFDGVLALHVDAKV 493
            ..|:|.||.|||||||||...:|.||||.|.|..:|.....|.:.:.|..:|:|.|:|:
Zfish   454 VSLSTGLPGGTYCDVISGQKENGRCTGKEVNVGGDGKASFRISNQEEDPFIAIHADSKL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amyrel	NP_477262.1	AmyAc_bac_euk_AmyA	29..398	CDD:200456	191/394 (48%)
Amyrel	NP_477262.1	Aamy_C	404..492	CDD:214749	43/87 (49%)
amy2a	NP_998176.2	AmyAc_bac_euk_AmyA	25..417	CDD:200456	191/394 (48%)
amy2a	NP_998176.2	Aamy_C	424..511	CDD:214749	43/86 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576476
Domainoid	1	1.000	269	1.000	Domainoid score	I1797
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	577	1.000	Inparanoid score	I1002
OMA	1	1.010	-	-		QHG53143
OrthoDB	1	1.010	-	-		D231864at33208
OrthoFinder	1	1.000	-	-		FOG0000926
OrthoInspector	1	1.000	-	-		mtm6522
orthoMCL	1	0.900	-	-		OOG6_103366
Panther	1	1.100	-	-	O	PTHR43447
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X338
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.770