DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Amyrel and Amy-d

DIOPT Version :9

Sequence 1:	NP_477262.1	Gene:	Amyrel / 36863	FlyBaseID:	FBgn0020506	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_523768.1	Gene:	Amy-d / 36932	FlyBaseID:	FBgn0000078	Length:	494	Species:	Drosophila melanogaster

Alignment Length:	489	Identity:	295/489 - (60%)
Similarity:	365/489 - (74%)	Gaps:	7/489 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LCLA-GSLSLAQHNPHWWGNRNTIVHLFEWKWSDIAQECESFLGPRGFAGVQVSPVNENILSAGR 73
            :||: .:::.||.:.::...|:.:||||||||.|||.|||:||||.|:|||||||||||.:...|
  Fly     8 VCLSLLAVANAQFDTNYASGRSGMVHLFEWKWDDIAAECENFLGPNGYAGVQVSPVNENAVKDSR 72

  Fly    74 PWWERYQPISYKLTTRSGNEEEFGDMVRRCNDVGVRIYVDVLLNHMSGDFDGVAVGTAGTEAEPS 138
            |||||||||||||.|||||||:|..||:|||.||||.||||:.|||:.  ||...||.|:.|.||
  Fly    73 PWWERYQPISYKLETRSGNEEQFASMVKRCNAVGVRTYVDVVFNHMAA--DGGTYGTGGSTASPS 135

  Fly   139 KKSFPGVPYTAQDFHPTCEITDWNDRFQVQQCELVGLKDLDQSSDWVRSKLIEFLDHLIELGVAG 203
            .||:|||||::.||:|||.|:::||..:|:.||||||:||:|.:.:|:.|::|||||||:|||||
  Fly   136 SKSYPGVPYSSLDFNPTCAISNYNDANEVRNCELVGLRDLNQGNSYVQDKVVEFLDHLIDLGVAG 200

  Fly   204 FRVDAAKHMASEDLEYIYSSLSNLNIDHGFPHNSRPFIFQEVIDHGHETVSRDEYKDLGAVTEFR 268
            |||||||||...||..||..|.|||.||||...|:.:|.|||||.|.|.:|:.||..|||:||||
  Fly   201 FRVDAAKHMWPADLAVIYGRLKNLNTDHGFASGSKAYIVQEVIDMGGEAISKSEYTGLGAITEFR 265

  Fly   269 FSEEIGNAFRGNNALKWLQSWGTDWGFLPSGQALTFVDNHDNQRDAGA----VLNYKSPRQYKMA 329
            .|:.||..|||.:.|::|.:|||.|||..|.::|.|||||||||..||    ||.||.|:|||||
  Fly   266 HSDSIGKVFRGKDQLQYLTNWGTAWGFAASDRSLVFVDNHDNQRGHGAGGADVLTYKVPKQYKMA 330

  Fly   330 TAFHLAYPYGISRVMSSFAFDDHDTPPPQDAQERIISPEFDADGACVNGWICEHRWRQIYAMVGF 394
            :||.||:|:|..||||||:|.|.|..||......|.||.|::|.:|..||:|||||||||.||.|
  Fly   331 SAFMLAHPFGTPRVMSSFSFTDTDQGPPTTDGHNIASPIFNSDNSCSGGWVCEHRWRQIYNMVAF 395

  Fly   395 KNAVRDTEITGWWDNGDNQISFCRGNKGFLAINNNLYDLSQDLNTCLPAGTYCDVISGSLIDGSC 459
            :|||...||..|||:|.|||||.||::||:|.||:.|||:..|.|.|||||||||||||....||
  Fly   396 RNAVGLDEIQNWWDSGSNQISFSRGSRGFVAFNNDNYDLNSSLQTGLPAGTYCDVISGSKSGSSC 460

  Fly   460 TGKSVTVNENGYGYIHIGSDDFDGVLALHVDAKV 493
            |||:|||..:|...|:|||.:.|||||:||:||:
  Fly   461 TGKTVTVGSDGRASIYIGSSEDDGVLAIHVNAKL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amyrel	NP_477262.1	AmyAc_bac_euk_AmyA	29..398	CDD:200456	231/372 (62%)
Amyrel	NP_477262.1	Aamy_C	404..492	CDD:214749	54/87 (62%)
Amy-d	NP_523768.1	AmyAc_bac_euk_AmyA	28..399	CDD:200456	231/372 (62%)
		Alpha-amylase	54..342	CDD:278554	180/289 (62%)
		Aamy_C	405..493	CDD:214749	54/87 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469405
Domainoid	1	1.000	43	1.000	Domainoid score	I4741
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	45	1.000	Inparanoid score	I2673
Isobase	1	0.950	-	0	Normalized mean entropy	S3326
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D231864at33208
OrthoFinder	1	1.000	-	-		FOG0000926
OrthoInspector	1	1.000	-	-		mtm6522
orthoMCL	1	0.900	-	-		OOG6_103366
Panther	1	1.100	-	-	P	PTHR43447
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X338
	12	11.750