DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Amyrel and AMY2B

DIOPT Version :9

Sequence 1:	NP_477262.1	Gene:	Amyrel / 36863	FlyBaseID:	FBgn0020506	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_001373038.1	Gene:	AMY2B / 280	HGNCID:	478	Length:	511	Species:	Homo sapiens

Alignment Length:	521	Identity:	249/521 - (47%)
Similarity:	334/521 - (64%)	Gaps:	42/521 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FKFALTLTLCLAGSLSLAQHNPHWWGNRNTIVHLFEWKWSDIAQECESFLGPRGFAGVQVSPVNE 66
            |....|:..|      .||::|:....|.:|||||||:|.|||.|||.:|.|:||.||||||.||
Human     4 FLLLFTIGFC------WAQYSPNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPPNE 62

  Fly    67 NIL--SAGRPWWERYQPISYKLTTRSGNEEEFGDMVRRCNDVGVRIYVDVLLNHMSGDFDGVAVG 129
            |:.  :..|||||||||:||||.||||||:||.:||.|||:||||||||.::|||||  :.|:.|
Human    63 NVAIHNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMSG--NAVSAG 125

  Fly   130 TA---GTEAEPSKKSFPGVPYTAQDFHP-TC-----EITDWNDRFQVQQCELVGLKDLDQSSDWV 185
            |:   |:...|..:.||.|||:..||:. .|     :|.::||..||:.|.||||.||....|:|
Human   126 TSSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLVGLLDLALEKDYV 190

  Fly   186 RSKLIEFLDHLIELGVAGFRVDAAKHMASEDLEYIYSSLSNLNIDHGFPHNSRPFIFQEVIDHGH 250
            |||:.|:::|||::||||||:||:|||...|::.|...|.||| .:.||..|:|||:|||||.|.
Human   191 RSKIAEYMNHLIDIGVAGFRLDASKHMWPGDIKAILDKLHNLN-SNWFPAGSKPFIYQEVIDLGG 254

  Fly   251 ETVSRDEYKDLGAVTEFRFSEEIGNAFRGNNA--LKWLQSWGTDWGFLPSGQALTFVDNHDNQRD 313
            |.:...:|...|.||||::..::|...|..|.  :.:|::||..|||:||.:||.|||||||||.
Human   255 EPIKSSDYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWGFMPSDRALVFVDNHDNQRG 319

  Fly   314 AGA----VLNYKSPRQYKMATAFHLAYPYGISRVMSSFAF----------DDHDTPPPQDA--QE 362
            .||    :|.:...|.||||..|.||:|||.:|||||:.:          :|...||..:.  :|
Human   320 HGAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWPRQFQNGNDVNDWVGPPNNNGVIKE 384

  Fly   363 RIISPEFDADGACVNGWICEHRWRQIYAMVGFKNAVRDTEITGWWDNGDNQISFCRGNKGFLAIN 427
            ..|:|    |..|.|.|:||||||||..||.|:|.|.....|.|:|||.||::|.|||:||:..|
Human   385 VTINP----DTTCGNDWVCEHRWRQIRNMVNFRNVVDGQPFTNWYDNGSNQVAFGRGNRGFIVFN 445

  Fly   428 NNLYDLSQDLNTCLPAGTYCDVISGSLIDGSCTGKSVTVNENGYGYIHIGSDDFDGVLALHVDAK 492
            |:.:..|..|.|.||||||||||||..|:|:|||..:.|:::|..:..|.:...|..:|:|.::|
Human   446 NDDWTFSLTLQTGLPAGTYCDVISGDKINGNCTGIKIYVSDDGKAHFSISNSAEDPFIAIHAESK 510

  Fly   493 V 493
            :
Human   511 L 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amyrel	NP_477262.1	AmyAc_bac_euk_AmyA	29..398	CDD:200456	200/397 (50%)
Amyrel	NP_477262.1	Aamy_C	404..492	CDD:214749	41/87 (47%)
AMY2B	NP_001373038.1	AmyAc_bac_euk_AmyA	25..416	CDD:200456	200/397 (50%)
		PLN02447	<85..>155	CDD:215246	38/71 (54%)
		Aamy_C	422..510	CDD:214749	41/87 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	268	1.000	Domainoid score	I1866
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	550	1.000	Inparanoid score	I1140
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53143
OrthoDB	1	1.010	-	-		D231864at33208
OrthoFinder	1	1.000	-	-		FOG0000926
OrthoInspector	1	1.000	-	-		mtm8522
orthoMCL	1	0.900	-	-		OOG6_103366
Panther	1	1.100	-	-	O	PTHR43447
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X338
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.840