Protein Alignment Amyrel and AMY1A

DIOPT Version :9

• Sequence 1: NP_477262.1
• Gene: Amyrel / 36863
• FlyBaseID: FBgn0020506
• Length: 493
• Species: Drosophila melanogaster
• Sequence 2: NP_001008222.1
• Gene: AMY1A / 276
• HGNCID: 474
• Length: 511
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 248/522 - (47%)
• Similarity: 333/522 - (63%)
• Gaps: 42/522 - (8%)

  Fly     1 MFKFALTLTLCLAGSLSLAQHNPHWWGNRNTIVHLFEWKWSDIAQECESFLGPRGFAGVQVSPVN 65
            :|....|:..|      .||::.:....|.:|||||||:|.|||.|||.:|.|:||.||||||.|
Human     3 LFWLLFTIGFC------WAQYSSNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPPN 61

  Fly    66 ENIL--SAGRPWWERYQPISYKLTTRSGNEEEFGDMVRRCNDVGVRIYVDVLLNHMSGDFDGVAV 128
            ||:.  :..|||||||||:||||.||||||:||.:||.|||:||||||||.::|||.|  :.|:.
Human    62 ENVAIHNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMCG--NAVSA 124

  Fly   129 GTA---GTEAEPSKKSFPGVPYTAQDFHP-TC-----EITDWNDRFQVQQCELVGLKDLDQSSDW 184
            ||:   |:...|..:.||.|||:..||:. .|     :|.::||..||:.|.|.||.||....|:
Human   125 GTSSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLSGLLDLALGKDY 189

  Fly   185 VRSKLIEFLDHLIELGVAGFRVDAAKHMASEDLEYIYSSLSNLNIDHGFPHNSRPFIFQEVIDHG 249
            ||||:.|:::|||::||||||:||:|||...|::.|...|.||| .:.||..|:|||:|||||.|
Human   190 VRSKIAEYMNHLIDIGVAGFRIDASKHMWPGDIKAILDKLHNLN-SNWFPEGSKPFIYQEVIDLG 253

  Fly   250 HETVSRDEYKDLGAVTEFRFSEEIGNAFRGNNA--LKWLQSWGTDWGFLPSGQALTFVDNHDNQR 312
            .|.:...:|...|.||||::..::|...|..|.  :.:|::||..|||:||.:||.|||||||||
Human   254 GEPIKSSDYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWGFMPSDRALVFVDNHDNQR 318

  Fly   313 DAGA----VLNYKSPRQYKMATAFHLAYPYGISRVMSSFAF--------DDHD-TPPPQD---AQ 361
            ..||    :|.:...|.||||..|.||:|||.:|||||:.:        |.:| ..||.|   .:
Human   319 GHGAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWPRYFENGKDVNDWVGPPNDNGVTK 383

  Fly   362 ERIISPEFDADGACVNGWICEHRWRQIYAMVGFKNAVRDTEITGWWDNGDNQISFCRGNKGFLAI 426
            |..|:|    |..|.|.|:||||||||..||.|:|.|.....|.|:|||.||::|.|||:||:..
Human   384 EVTINP----DTTCGNDWVCEHRWRQIRNMVNFRNVVDGQPFTNWYDNGSNQVAFGRGNRGFIVF 444

  Fly   427 NNNLYDLSQDLNTCLPAGTYCDVISGSLIDGSCTGKSVTVNENGYGYIHIGSDDFDGVLALHVDA 491
            ||:.:..|..|.|.||||||||||||..|:|:|||..:.|:::|..:..|.:...|..:|:|.::
Human   445 NNDDWTFSLTLQTGLPAGTYCDVISGDKINGNCTGIKIYVSDDGKAHFSISNSAEDPFIAIHAES 509

  Fly   492 KV 493
            |:
Human   510 KL 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Amyrel	NP_477262.1	AmyAc_bac_euk_AmyA	29..398	CDD:200456	200/397 (50%)
		Aamy_C	404..492	CDD:214749	41/87 (47%)
AMY1A	NP_001008222.1	AmyAc_bac_euk_AmyA	25..416	CDD:200456	200/397 (50%)
		Aamy_C	422..510	CDD:214749	41/87 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	268	1.000	Domainoid score	I1866
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	550	1.000	Inparanoid score	I1140
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53143
OrthoDB	1	1.010	-	-		D231864at33208
OrthoFinder	1	1.000	-	-		FOG0000926
OrthoInspector	1	1.000	-	-		mtm8522
orthoMCL	1	0.900	-	-		OOG6_103366
Panther	1	1.100	-	-	O	PTHR43447
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X338
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840