DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Amyrel and Mal-A6

DIOPT Version :9

Sequence 1:	NP_477262.1	Gene:	Amyrel / 36863	FlyBaseID:	FBgn0020506	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_724679.2	Gene:	Mal-A6 / 246565	FlyBaseID:	FBgn0050360	Length:	601	Species:	Drosophila melanogaster

Alignment Length:	577	Identity:	116/577 - (20%)
Similarity:	195/577 - (33%)	Gaps:	160/577 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ALTLTLCLAGSLSLAQHNPHWWGNRNTIVHLFE-----WKWSD---------IAQECESFLGPRG 55
            |..:.|.|..:.:.|.....||    .:...::     :|.||         |..:.: :|...|
  Fly    23 AAAVDLDLERATTAADTTRDWW----QVAQFYQIYPRSYKDSDGDGIGDLQGIISKLD-YLKEIG 82

  Fly    56 FAGVQVSPVNENILSAGRPWWERYQPIS--YKLTTRSGNEEEFGDMVRRCNDVGVRIYVDVLLNH 118
            .....:||:..:      |..:....||  :.:....|...:|.:::.......::|.:|.:.||
  Fly    83 VTATWLSPIYSS------PMADFGYDISDFFDIQPEYGTLADFDELIAEAKKRNIKIILDFVPNH 141

  Fly   119 MSGD--------------------FDGVAVGTAGTEAEPSK--KSFPGVPYTAQDFHPTCEITDW 161
            .|.:                    .||....|.|....||.  ::|.|..:            :|
  Fly   142 SSDENVWFQKSVKREKGYEDYYMWHDGYVNATTGKREPPSNWLQAFRGSAW------------EW 194

  Fly   162 NDRFQVQQCELVGLK--DLDQSSDWVRSKLIEFLDHLIELGVAGFRVDAA----KHMASEDLEYI 220
            ||..|........:|  ||:..:..|.:::...|.:.::.||||||:||.    :.:...|..|.
  Fly   195 NDERQQYYLHQFAVKQPDLNYRNPAVVAQMKRVLTYWLDRGVAGFRMDAVPWCFEVLPDADGRYP 259

  Fly   221 YSSLSNLNID--------HGFPHNSRP-----FIFQEVID-----HGHET--VSRDEYKDL---- 261
            ...||....|        |.:..:.|.     |.::.::|     ||.:|  :..:.|..|
  Fly   260 DEPLSGYTDDPDDSSYLKHIYTQDLRETVEMVFQWRTLLDDYQRIHGGDTRVIMVETYSGLDYVM 324

  Fly   262 ---------GAVTEFRFSEEI-GNAFRGNNAL------KWLQSWGTDWGFLPSGQALTFV-DNHD 309
                     ||...|.|...| ||..:.|..|      |.:.||.:.   :|:||...:| .|||
  Fly   325 QFYGNRTTKGAQMPFNFQFIIGGNGDKNNTQLNATGFVKIISSWLSQ---MPAGQTANWVMGNHD 386

  Fly   310 NQRDAGAVLNYKSPRQYKMATAFHLAYPYGISRVMS---------SFAFDDHDTPPPQDAQERII 365
             ||..|:  .|...| ..:.....:..| |:|....         ..:::|...|...::...|.
  Fly   387 -QRRVGS--RYGENR-IDLMNMLQMFLP-GVSITYQGEELGMTDLDISWEDSRDPAACNSNSDIY 446

  Fly   366 SPEFDADGACVNGWICEHRWRQIYAMVGFKNAVRDTEITGWWDNGDNQISF-----CRGNKGFLA 425
            . :|..|.|           |..:......||...|..|.|.....|.::.     ...:...|:
  Fly   447 E-QFTRDPA-----------RTPFQWSDEANAGFSTNATTWLPINPNYVTVNAKAENSTSPSHLS 499

  Fly   426 INNNLYDLSQDLNTCLPAGTYCDV----------ISG--------SLIDGSCTGKSV 464
            :...|.||.:.......|..|.:|          :||        :::|.|.:|..|
  Fly   500 LYKQLVDLRKSKTLQFGATRYANVGDNVVAIRRYLSGEPSYVLVANVLDTSVSGIDV 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amyrel	NP_477262.1	AmyAc_bac_euk_AmyA	29..398	CDD:200456	92/462 (20%)
Amyrel	NP_477262.1	Aamy_C	404..492	CDD:214749	16/84 (19%)
Mal-A6	NP_724679.2	AmyAc_maltase	40..516	CDD:200467	103/518 (20%)
Mal-A6	NP_724679.2	trehalose_treC	43..599	CDD:274115	112/557 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443619
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830