DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Amyrel and Amy1

DIOPT Version :9

Sequence 1:	NP_477262.1	Gene:	Amyrel / 36863	FlyBaseID:	FBgn0020506	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_001103975.1	Gene:	Amy1 / 11722	MGIID:	88019	Length:	511	Species:	Mus musculus

Alignment Length:	518	Identity:	254/518 - (49%)
Similarity:	328/518 - (63%)	Gaps:	35/518 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KFALTLTLCLAGSLSLAQHNPHWWGNRNTIVHLFEWKWSDIAQECESFLGPRGFAGVQVSPVNEN 67
            ||.|.|:|.   ....||::||....|..|||||||:|.|||:|||.:|.|.|||||||||.|||
Mouse     2 KFFLLLSLI---GFCWAQYDPHTQYGRTAIVHLFEWRWVDIAKECERYLAPNGFAGVQVSPPNEN 63

  Fly    68 IL--SAGRPWWERYQPISYKLTTRSGNEEEFGDMVRRCNDVGVRIYVDVLLNHMSGDFDGVAVG- 129
            |:  |..|||||||||||||:.:|||||:||.|||.|||:||||||||.::|||.|  .|...|
Mouse    64 IVVHSPSRPWWERYQPISYKICSRSGNEDEFRDMVNRCNNVGVRIYVDAVINHMCG--VGAQAGQ 126

  Fly   130 --TAGTEAEPSKKSFPGVPYTAQDFHP-TCE-----ITDWNDRFQVQQCELVGLKDLDQSSDWVR 186
              |.|:...|:.:.||||||:..||:. .|.     |.::.|..||:.|.|.||.||....|:||
Mouse   127 SSTCGSYFNPNNRDFPGVPYSGFDFNDGKCRTASGGIENYQDAAQVRDCRLSGLLDLALEKDYVR 191

  Fly   187 SKLIEFLDHLIELGVAGFRVDAAKHMASEDLEYIYSSLSNLNIDHGFPHNSRPFIFQEVIDHGHE 251
            :|:.::::|||::||||||:||:|||...|::.|...|.||| ...|...|||||||||||.|.|
Mouse   192 TKVADYMNHLIDIGVAGFRLDASKHMWPGDIKAILDKLHNLN-TKWFSQGSRPFIFQEVIDLGGE 255

  Fly   252 TVSRDEYKDLGAVTEFRFSEEIGNAFR--GNNALKWLQSWGTDWGFLPSGQALTFVDNHDNQRDA 314
            .||.:||...|.||||::..::|...|  ....:.:|::||..||.:||.:||.|||||||||..
Mouse   256 AVSSNEYFGNGRVTEFKYGAKLGKVMRKWDGEKMSYLKNWGEGWGLMPSDRALVFVDNHDNQRGH 320

  Fly   315 GA----VLNYKSPRQYKMATAFHLAYPYGISRVMSSFAF----------DDHDTPPPQDAQERII 365
            ||    :|.:...|.||||..|.||:|||.:|||||:.:          :|...||..:.:.:.:
Mouse   321 GAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYYWPRNFQNGKDVNDWVGPPNNNGKTKEV 385

  Fly   366 SPEFDADGACVNGWICEHRWRQIYAMVGFKNAVRDTEITGWWDNGDNQISFCRGNKGFLAINNNL 430
            |  .:.|..|.|.||||||||||..||.|:|.|.......||||..||::|.||||||:..||:.
Mouse   386 S--INPDSTCGNDWICEHRWRQIRNMVAFRNVVNGQPFANWWDNDSNQVAFGRGNKGFIVFNNDD 448

  Fly   431 YDLSQDLNTCLPAGTYCDVISGSLIDGSCTGKSVTVNENGYGYIHIGSDDFDGVLALHVDAKV 493
            :.||:.|.|.||||||||||||..:||:|||..|.|..:|..:..|.:...|..:|:|.::|:
Mouse   449 WALSETLQTGLPAGTYCDVISGDKVDGNCTGIKVYVGNDGKAHFSISNSAEDPFIAIHAESKI 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amyrel	NP_477262.1	AmyAc_bac_euk_AmyA	29..398	CDD:200456	200/395 (51%)
Amyrel	NP_477262.1	Aamy_C	404..492	CDD:214749	43/87 (49%)
Amy1	NP_001103975.1	AmyAc_bac_euk_AmyA	25..416	CDD:200456	200/395 (51%)
		AmyA	46..>315	CDD:223443	140/271 (52%)
		Aamy_C	422..510	CDD:214749	43/87 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833810
Domainoid	1	1.000	273	1.000	Domainoid score	I1776
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	573	1.000	Inparanoid score	I1047
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53143
OrthoDB	1	1.010	-	-		D231864at33208
OrthoFinder	1	1.000	-	-		FOG0000926
OrthoInspector	1	1.000	-	-		mtm8751
orthoMCL	1	0.900	-	-		OOG6_103366
Panther	1	1.100	-	-	O	PTHR43447
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X338
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.770