DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Amyrel and Amy2a2

DIOPT Version :9

Sequence 1:	NP_477262.1	Gene:	Amyrel / 36863	FlyBaseID:	FBgn0020506	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_001153624.1	Gene:	Amy2a2 / 100043688	MGIID:	3711220	Length:	508	Species:	Mus musculus

Alignment Length:	515	Identity:	253/515 - (49%)
Similarity:	332/515 - (64%)	Gaps:	32/515 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KFALTLTLCLAGSLSLAQHNPHWWGNRNTIVHLFEWKWSDIAQECESFLGPRGFAGVQVSPVNEN 67
            ||.|.|:|.   ....||::||....|..|||||||:|.|||:|||.:|.|:||.||||||.|||
Mouse     2 KFVLLLSLI---GFCWAQYDPHTSDGRTAIVHLFEWRWVDIAKECERYLAPKGFGGVQVSPPNEN 63

  Fly    68 IL--SAGRPWWERYQPISYKLTTRSGNEEEFGDMVRRCNDVGVRIYVDVLLNHMSGDFDGVAVGT 130
            ::  :..|||||||||||||:.||||||:||.|||.|||:||||||||.::|||.|  .|...||
Mouse    64 VVVHNPSRPWWERYQPISYKICTRSGNEDEFRDMVTRCNNVGVRIYVDAVINHMCG--AGNPAGT 126

  Fly   131 A---GTEAEPSKKSFPGVPYTAQDFHPT-C--EITDWNDRFQVQQCELVGLKDLDQSSDWVRSKL 189
            :   |:...|:.:.||.|||:|.||:.. |  ||.::||.:||:.|.|.||.||....|:||:|:
Mouse   127 SSTCGSYLNPNNREFPAVPYSAWDFNDNKCNGEIDNYNDAYQVRNCRLTGLLDLALEKDYVRTKV 191

  Fly   190 IEFLDHLIELGVAGFRVDAAKHMASEDLEYIYSSLSNLNIDHGFPHNSRPFIFQEVIDHGHETVS 254
            .::::|||::||||||:||||||...|::.:...|.||| ...|...|||||||||||.|.|.:.
Mouse   192 ADYMNHLIDIGVAGFRLDAAKHMWPGDIKAVLDKLHNLN-TKWFSQGSRPFIFQEVIDLGGEAIK 255

  Fly   255 RDEYKDLGAVTEFRFSEEIGNAFRGNNA--LKWLQSWGTDWGFLPSGQALTFVDNHDNQRDAGA- 316
            ..||...|.||||::..::|...|..|.  :.:|::||..||.:||.:||.|||||||||..||
Mouse   256 GSEYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWGLVPSDRALVFVDNHDNQRGHGAG 320

  Fly   317 ---VLNYKSPRQYKMATAFHLAYPYGISRVMSSFAF--------DDHD--TPPPQDAQERIISPE 368
               :|.:...|.||||..|.||:|||.:|||||:.:        |.:|  .||..:...:.::
Mouse   321 GSSILTFWDARMYKMAVGFMLAHPYGFTRVMSSYRWNRNFQNGKDQNDWIGPPNNNGVTKEVT-- 383

  Fly   369 FDADGACVNGWICEHRWRQIYAMVGFKNAVRDTEITGWWDNGDNQISFCRGNKGFLAINNNLYDL 433
            .:||..|.|.|:||||||||..||.|:|.|.....:.||||..||::|.|||:||:..||:.:.|
Mouse   384 INADTTCGNDWVCEHRWRQIRNMVAFRNVVNGQPFSNWWDNNSNQVAFSRGNRGFIVFNNDDWAL 448

  Fly   434 SQDLNTCLPAGTYCDVISGSLIDGSCTGKSVTVNENGYGYIHIGSDDFDGVLALHVDAKV 493
            |..|.|.||||||||||||..:||:|||..|.|..:|..:..|.:...|..:|:|.|:|:
Mouse   449 SATLQTGLPAGTYCDVISGDKVDGNCTGLRVNVGSDGKAHFSISNSAEDPFIAIHADSKL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amyrel	NP_477262.1	AmyAc_bac_euk_AmyA	29..398	CDD:200456	199/392 (51%)
Amyrel	NP_477262.1	Aamy_C	404..492	CDD:214749	43/87 (49%)
Amy2a2	NP_001153624.1	AmyAc_bac_euk_AmyA	25..413	CDD:200456	199/392 (51%)
		AmyA	46..>344	CDD:223443	155/300 (52%)
		Aamy_C	420..507	CDD:214749	43/86 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833756
Domainoid	1	1.000	273	1.000	Domainoid score	I1776
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	573	1.000	Inparanoid score	I1047
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53143
OrthoDB	1	1.010	-	-		D231864at33208
OrthoFinder	1	1.000	-	-		FOG0000926
OrthoInspector	1	1.000	-	-		mtm8751
orthoMCL	1	0.900	-	-		OOG6_103366
Panther	1	1.100	-	-	O	PTHR43447
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X338
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.770