Protein Alignment gprs and ENC1

DIOPT Version :10

• Sequence 1: NP_725599.2
• Gene: gprs / 36862
• FlyBaseID: FBgn0024232
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_003624.1
• Gene: ENC1 / 8507
• HGNCID: 3345
• Length: 589
• Species: Homo sapiens
• Alignment Length: 272
• Identity: 61/272 - (22%)
• Similarity: 102/272 - (37%)
• Gaps: 73/272 - (26%)

  Fly    41 DVTFLVGDTREPVCAVKAVLASRSRVFAKMLYAAPSPQRKRETSTKENKLRLFLKRSSEPLLNLQ 105
            ||....|:...| |. :||||:.||.|..|....                   ||.|.:..:|..
Human    47 DVLLHAGNRTFP-CH-RAVLAACSRYFEAMFSGG-------------------LKESQDSEVNFD 90

  Fly   106 NAAQQRTGYTQQLAPIPEPSGQQHQTLIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADY 170
            |:                             ..|:|...|::|.::..|.:.......::.|.|.
Human    91 NS-----------------------------IHPEVLELLLDYAYSSRVIINEENAESLLEAGDM 126

  Fly   171 YGLEELRRACAGFVQCCINVDTVCALLASAERYIQYKCTKTLVQKVLEFVDEHGTEVLNLGSFTL 235
            ...:::|.|||.|::..::......:|..::   .::||| |.:........:...:.....|..
Human   127 LEFQDIRDACAEFLEKNLHPTNCLGMLLLSD---AHQCTK-LYELSWRMCLSNFQTIRKNEDFLQ 187

  Fly   236 LPQHVVRLILAREELRA-DEFTKFQAALMW----SKKYYDNNPNIDIKEILGTFCEYIQFHKIPA 295
            |||.:|..:|:.|||.. ||...:::|:.|    .||.|...|     |:|.|    ::...:||
Human   188 LPQDMVVQLLSSEELETEDERLVYESAINWISYDLKKRYCYLP-----ELLQT----VRLALLPA 243

  Fly   296 -----NVLMREI 302
                 ||.|.|:
Human   244 IYLMENVAMEEL 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gprs	NP_725599.2	BTB_POZ_BTBD19	26..184	CDD:349603	29/142 (20%)
		BACK_GPRS_like	189..268	CDD:350582	19/83 (23%)
ENC1	NP_003624.1	BTB_POZ_KLHL37_ENC1	6..152	CDD:349576	30/154 (19%)
		PHA03098	48..566	CDD:222983	60/271 (22%)
		BACK_KLHL37_ENC1	145..242	CDD:350590	25/109 (23%)
		Kelch 1	296..340
		KELCH repeat	330..374	CDD:276965
		Kelch 2	341..388
		KELCH repeat	378..431	CDD:276965
		Kelch 3	389..444
		KELCH repeat	434..480	CDD:276965
		Kelch 4	446..492
		Kelch 5	494..538
		KELCH repeat	528..568	CDD:276965
		Kelch 6	539..585