Protein Alignment gprs and KLHL25

DIOPT Version :10

• Sequence 1: NP_725599.2
• Gene: gprs / 36862
• FlyBaseID: FBgn0024232
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: XP_054234589.1
• Gene: KLHL25 / 64410
• HGNCID: 25732
• Length: 619
• Species: Homo sapiens
• Alignment Length: 291
• Identity: 58/291 - (19%)
• Similarity: 99/291 - (34%)
• Gaps: 93/291 - (31%)

  Fly    41 DVTFLVGDTREPVCAVKAVLASRSRVFAKMLYAAPSPQRKRETSTKENKLRLFLKRSSEPLLNLQ 105
            |||...||...| |. :||||:.||.|..|....                   |:.|.:..:|.|
Human    77 DVTLWAGDRAFP-CH-RAVLAASSRYFEAMFSHG-------------------LRESRDDTVNFQ 120

  Fly   106 NAAQQRTGYTQQLAPIPEPSGQQHQTLIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADY 170
                                         :...|:|...|:::.::..:.:.......::.|.|.
Human   121 -----------------------------DNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDM 156

  Fly   171 YGLEELRRACAGFVQ------CCINVDTVCALLASA---ERYIQYKCTKTLVQKVLEFVDEHGTE 226
            ....::|.|.|.|::      .|:.:    .||:.|   .|..::.....||         |...
Human   157 LQFHDVRDAAAEFLEKNLFPSNCLGM----MLLSDAHQCRRLYEFSWRMCLV---------HFET 208

  Fly   227 VLNLGSFTLLPQHVVRLILAREELRA-DEFTKFQAALMWSKKYYDNNPNIDIKEILGTFCEYIQF 290
            |.....|..|.:..:..:::.:||.. ||...|:|.|.|.|  :|..|
Human   209 VRQSEDFNSLSKDTLLDLISSDELETEDERVVFEAILQWVK--HDLEP----------------- 254

  Fly   291 HKIPANVLMREIHPLNLVPYAIIMNALAYQA 321
            .|:....|:|.:. |.|:|...:..|::.:|
Human   255 RKVHLPELLRSVR-LALLPSDCLQEAVSSEA 284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gprs	NP_725599.2	BTB_POZ_BTBD19	26..184	CDD:349603	27/142 (19%)
		BACK_GPRS_like	189..268	CDD:350582	19/82 (23%)
KLHL25	XP_054234589.1	BTB_POZ_KLHL25	54..181	CDD:349563	29/153 (19%)
		PHA03098	69..596	CDD:222983	58/291 (20%)
		BACK_KLHL25_ENC2	174..272	CDD:350589	27/130 (21%)
		KELCH repeat	360..404	CDD:276965
		KELCH repeat	408..461	CDD:276965
		KELCH repeat	464..510	CDD:276965
		KELCH repeat	512..554	CDD:276965