Protein Alignment gprs and Spop

DIOPT Version :10

• Sequence 1: NP_725599.2
• Gene: gprs / 36862
• FlyBaseID: FBgn0024232
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_079563.2
• Gene: Spop / 20747
• MGIID: 1343085
• Length: 374
• Species: Mus musculus
• Alignment Length: 247
• Identity: 49/247 - (19%)
• Similarity: 97/247 - (39%)
• Gaps: 69/247 - (27%)

  Fly    15 PDLSTFENKTGLAEDMKFLASMPELCDVTFLVGDTREPVCAVKAVLASRSRVFAKMLYAAPSPQR 79
            |:....:...||.|:.:|....  ||    :.|...:   |.||:||:||.||:.|.      :.
Mouse   182 PECRLADELGGLWENSRFTDCC--LC----VAGQEFQ---AHKAILAARSPVFSAMF------EH 231

  Fly    80 KRETSTKENKLRLFLKRSSEPLLNLQNAAQQRTGYTQQLAPIPEPSGQQHQTLIIEEFEPDVFRQ 144
            :.|.| |:|::.                                          |.:.||:||::
Mouse   232 EMEES-KKNRVE------------------------------------------INDVEPEVFKE 253

  Fly   145 LIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACAGFVQCCINVDTVCALLASAERYIQYKCT 209
            ::.:|:||......:....::.|||.|.||.|:..|...:...::|:....:|..|:.:    ..
Mouse   254 MMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLH----SA 314

  Fly   210 KTLVQKVLEFVDEHGTEVLNLGSFTLLPQHVVRLILAREELRADEFTKFQAA 261
            ..|..:.::|::.|.::||....:.       .::::...|.|:.:....:|
Mouse   315 DQLKTQAVDFINYHASDVLETSGWK-------SMVVSHPHLVAEAYRSLASA 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gprs	NP_725599.2	BTB_POZ_BTBD19	26..184	CDD:349603	36/157 (23%)
		BACK_GPRS_like	189..268	CDD:350582	11/73 (15%)
Spop	NP_079563.2	MATH_SPOP	28..166	CDD:239743
		Required for nuclear localization. /evidence=ECO:0000250	71..191		1/8 (13%)
		Important for binding substrate proteins. /evidence=ECO:0000250	123..133
		BTB_POZ_SPOP-like	182..301	CDD:349588	39/176 (22%)
		Important for homodimerization. /evidence=ECO:0000250	186..217		9/39 (23%)
		BACK_SPOP	297..367	CDD:350593	11/74 (15%)
		Important for homodimerization. /evidence=ECO:0000250	297..355		10/68 (15%)