Protein Alignment gprs and BTBD19

DIOPT Version :10

• Sequence 1: NP_725599.2
• Gene: gprs / 36862
• FlyBaseID: FBgn0024232
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: XP_011539105.1
• Gene: BTBD19 / 149478
• HGNCID: 27145
• Length: 470
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 124/558 - (22%)
• Similarity: 183/558 - (32%)
• Gaps: 186/558 - (33%)

  Fly     2 PEALILPGMADAEPDLSTFENKTGLAEDMKFLASMPELCDVTFLVGDTREPVCAVKAVLASRSRV 66
            |..|::.|  .|||          .:..::.|.:.|...||.|:||..|:.|.|.:.:||.|...
Human     3 PLGLVVHG--KAEP----------FSAALRSLVNNPRYSDVCFVVGQERQEVFAHRCLLACRCNF 55

  Fly    67 FAKML-----YAAPSPQRKRETSTK----------ENKLRLFLKRSSEPLL-----------NLQ 105
            |.::|     ...|||.......|:          .|.::|:  |.|..||           ..|
Human    56 FQRLLGTEPGPGVPSPVVLSTVPTEAFLAVLEFLYTNSVKLY--RHSVSLLTRGLGGRGGGCQRQ 118

  Fly   106 NAAQQRTGYTQQLAPIPEPS------------------GQQHQTLIIEEFEPDVFRQLIEYIHTG 152
            ..|....|..|...|...|:                  |.:....:.:  .|..|..|:    ||
Human   119 EFAHYTVGTGQGKLPSTPPTTHSTGAGSADSGCGVWAGGTERGGFLCQ--VPVSFPLLL----TG 177

  Fly   153 CVTLQPRTLLGVMNAADYYGLEE-----------LRRACAGFVQCCINVDTVCALLASAERY--- 203
            .:...|.|         :.|||.           |.:.|..||...::||.||..|..|..:
Human   178 SLPALPHT---------HSGLERNVCPHREKYVYLSQLCLQFVVKVLDVDLVCEALQVAVTFGLG 233

  Fly   204 -IQYKCTKTLVQKVLEFVDEHGTEVLNLGSFTLLPQHVVRLILAREELRADEFTKFQAALMWSKK 267
             :|.:|        :.|::.|..|.|....|..|....:..:|..::|..||....:||..|:
Human   234 QLQERC--------VAFIEAHSQEALRTRGFLELSAAALLPLLRSDKLCVDEAELVRAARSWA-- 288

  Fly   268 YYDNNPNIDIKEILGTFCEYIQFHKIPANVLMREIHPLNLVPYAIIMNALAYQADPESIDPGKLS 332
                                    ::.|.||.|        |.|.:...:..:.....:.|.:||
Human   289 ------------------------RVGAAVLER--------PVAEVAAPVVKELRLALLAPAELS 321

  Fly   333 --PNSSRQHHRHRHHHQSLPKIRKAKSQSFRTRRSPSERRSPNNAPNLTLNTS--LTSGNGEKKR 393
              ...:||.          |.|             |...|....|| |:...|  ...||.....
Human   322 ALEEQNRQE----------PLI-------------PVGTRGTGPAP-LSRGWSRLWRRGNAMPCG 362

  Fly   394 SPLTPKSPVMPVPESKSPGS--------SSQKTPTSLSRQGTLRASNRRKNSGQLSISLGTQGRR 450
            ..:.|.:|.:...|:..|||        |:..||       .|..|.|   ..|||:...|
Human   363 EGMRPGAPRVAAGEAPCPGSITAFWTCPSNDPTP-------GLAGSPR---PAQLSLPQTT---- 413

  Fly   451 SPVGLNDRSPQGRRSPLFPSSGLRSPNDPMTSPTVRSP 488
            :|..|..||  |...|..|.|  |:|.:|:::  .|||
Human   414 APEVLGVRS--GLPFPACPVS--RAPEEPLSA--TRSP 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gprs	NP_725599.2	BTB_POZ_BTBD19	26..184	CDD:349603	44/212 (21%)
		BACK_GPRS_like	189..268	CDD:350582	21/82 (26%)
BTBD19	XP_011539105.1	BTB_POZ_BTBD19	15..>101	CDD:349603	22/87 (25%)
		BACK_BTBD19	221..288	CDD:350569	17/74 (23%)