Protein Alignment gprs and gprs

DIOPT Version :10

• Sequence 1: NP_725599.2
• Gene: gprs / 36862
• FlyBaseID: FBgn0024232
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: XP_061514418.1
• Gene: gprs / 1280431
• VectorBaseID: AGAMI1_000813
• Length: 1295
• Species: Anopheles gambiae
• Alignment Length: 1444
• Identity: 733/1444 - (50%)
• Similarity: 881/1444 - (61%)
• Gaps: 291/1444 - (20%)

  Fly     1 MPEALILPGMADAEPDLSTFENKTGLAEDMKFLASMPELCDVTFLVGDTREPVCAVKAVLASRSR 65
            |||.|.|.|||||||||||||||:|||||||||||||||||||||||:|||||||||||||:|||
Mosquito     1 MPEVLPLSGMADAEPDLSTFENKSGLAEDMKFLASMPELCDVTFLVGETREPVCAVKAVLAARSR 65

  Fly    66 VFAKMLYAAPSPQRKRETSTKENKLRLFLKRSSEPLLNLQNAAQQRTGYTQQLAPIPEPSGQQHQ 130
            ||.||||.|||||||:|...:||||||||||||||||||||||||             |:|||||
Mosquito    66 VFQKMLYQAPSPQRKKEPPPRENKLRLFLKRSSEPLLNLQNAAQQ-------------PAGQQHQ 117

  Fly   131 TLIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACAGFVQCCINVDTVCA 195
            ||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||
Mosquito   118 TLIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACGGFVQCCINVDTVCA 182

  Fly   196 LLASAERYIQYKCTKTLVQKVLEFVDEHGTEVLNLGSFTLLPQHVVRLILAREELRADEFTKFQA 260
            |||||||||||||||:|||||||||||||.|||||||||||||||||||||||||||||||||||
Mosquito   183 LLASAERYIQYKCTKSLVQKVLEFVDEHGNEVLNLGSFTLLPQHVVRLILAREELRADEFTKFQA 247

  Fly   261 ALMWSKKYYDNNPNIDIKEILGTFCEYIQFHKIPANVLMREIHPLNLVPYAIIMNALAYQADPES 325
            ||||||||.|:|.|..:||::|.|.||||||||||||||||:|||.||||:||||||||||||.|
Mosquito   248 ALMWSKKYCDSNQNTPLKEVIGNFLEYIQFHKIPANVLMREVHPLGLVPYSIIMNALAYQADPAS 312

  Fly   326 IDPGKLSPNSSRQHHRHRHHHQ----------SLPKIRKAKSQSFRTRRSPSERRSP-NNAPNLT 379
            :|||||||||||.||..:|.||          ||||||||||||||||||||||.|. .:.....
Mosquito   313 VDPGKLSPNSSRHHHHSQHLHQPNSGGSSSSRSLPKIRKAKSQSFRTRRSPSERSSKGGHVSPWN 377

  Fly   380 LNTSLTSGNGE----KKRSPLTPKSPV--MPVPESKSPGSSSQKTPTSLSRQGTLRASNRRKNSG 438
            .:..|::|.|.    :::....|||||  |...|......||.|:| .||||||||:|:|||:|.
Mosquito   378 FSAQLSTGTGTSTQVQQQQQQLPKSPVGSMTHLEQHRSSISSAKSP-CLSRQGTLRSSHRRKSSL 441

  Fly   439 QLSISLGTQGRRSPVG-LNDRSPQG-------------------RRSPLFPS-------SGLRSP 476
            ..|::| :||||||:. ||||||.|                   ||||...|       ||||||
Mosquito   442 GASLNL-SQGRRSPISMLNDRSPSGRPKSPNLLITDQAYASSFDRRSPTAMSFSGRRSPSGLRSP 505

  Fly   477 NDPMTSPT-VRSPTGEPRRSSPTFSVHTQERRSPLGAVAPTDFGCQFGVPGTRRSPTSTVHVQDM 540
            :..:.||: .|||.|...:|..:..:.:|:.|     .:|..........|..|..:.|:|:
Mosquito   506 SGGLRSPSGRRSPLGFNLQSEYSELLQSQQDR-----FSPNSLSSHQSTSGADRRTSPTIHL--- 562

  Fly   541 ATEPEEA----GFVGLKRPSISLFTPIYFASEKRS------PMGPIPPITVSNPAETY----KSA 591
              .||.:    ||.  .|...||:.|:  .||.||      .:|.|||||:|||:|||    ||.
Mosquito   563 --PPERSRSPVGFG--SRLGGSLYGPV--GSESRSARTSPTTLGTIPPITISNPSETYEIVQKSI 621

  Fly   592 EREREAAEAAAREKEKEKEKEAAQPQ---------------EKKSVMREILAFVRKPSKHLSSRT 641
            |..::..:.....|..:..|...:|:               ||.|||:|||||||||||.:::||
Mosquito   622 ETNQQQQQQQRSPKSPKSPKSPMKPEPGAANGGGQSAPEKKEKTSVMKEILAFVRKPSKKVTTRT 686

  Fly   642 NRFANAFTRAESGSSGGPLIRQSTFSASPAASSTAAKSAVQKQMSEVGFEPKISQ-KFTHY-AKM 704
            ::||.||||.|| ::|.||:||||||:...:||.|.::|:.|||||:.|||.:|. |:.:. :||
Mosquito   687 SKFAAAFTRTES-TTGAPLLRQSTFSSIQNSSSCAGRNAITKQMSEIAFEPIMSSLKWKNVGSKM 750

  Fly   705 SL----RLRRSTKRDDEEKEKQKQSSASGSKRPSADLSQTNADQQVGGSS-----DELPFE-LAN 759
            ||    :|.:......:.:.:.|:||..       ::|...:.....|:|     .|..|| |.:
Mosquito   751 SLKSLKKLSQGMSVTSDGRSRDKRSSGD-------EVSDVESSDGAAGASGIPNASEAVFEVLES 808

  Fly   760 VHFEKVGESYIKHERLRELQEPEVVKEEDTEKDAEAEVEVEQTDAAMAQF--VEEVTNSLKVVAL 822
            ||||||||:||||:::||.:.|...::.....|.:   |...:|:...:.  |.|:..||:.:
Mosquito   809 VHFEKVGEAYIKHDQIREEESPRGSQDSAAGSDDD---ERHGSDSGRLRVTAVSEIKKSLEAL-- 868

  Fly   823 NGEGGTAAVHHFTRRSESREPIEPRISEERESDSNDLMIPDDMRAELVEILKAYPPEPVYVNLQA 887
                       |||    :|||:
Mosquito   869 -----------FTR----QEPID------------------------------------------ 876

  Fly   888 LRRETEDADLAIAQAEAAALAAAEPAKKP--LQCPTIEFEPPSRRSSFDPPRSPFLEQLRSPGVD 950
                           ||....|....::|  :||||.|.||||||:|||||||||||.|||.. |
Mosquito   877 ---------------EAGETGATGTTREPDAIQCPTFEIEPPSRRASFDPPRSPFLENLRSLS-D 925

  Fly   951 TETDLINLQRLDSGGDSFELVESKWSKSSRGESSFDCPYSSRDTSFDVSISRYQSTSYEDQTSSF 1015
            |:.:..:..||||||||||::::  :....|.|.....:||.|||||  ||||||||||||.|||
Mosquito   926 TDHEGTHHSRLDSGGDSFEMIDT--TDRMPGSSVSGDRHSSMDTSFD--ISRYQSTSYEDQNSSF 986

  Fly  1016 EIVDTDEKGQGRRAV---DLRKSSIELVDAETFQRSGSSCGGRKSSLETHFDYTPT--------E 1069
            |:|:.|...:|.:.:   |:|||||||||||||||||.. .|||||||||||...:        :
Mosquito   987 ELVELDNSQRGDKTLSPFDIRKSSIELVDAETFQRSGYP-EGRKSSLETHFDLADSYQQHQQHQQ 1050

  Fly  1070 GGGRSPSLPFPAMS------KKQRTENFR------------------QLHVSQFSAFSRARSPLS 1110
            ....||...|..:|      :||.:|..|                  :.|   :||..||:||||
Mosquito  1051 QRSASPRSAFSLISNSRAPTRKQISEPGRCRDSLPRSGAPAGTGTGMKTH---YSAPHRAKSPLS 1112

  Fly  1111 QQTSSNYSSRDSYDS-SGSYPHGYGYPPEP--------QRSPY--GDPSRKHFPLTVRQKGEEER 1164
            .|||||:|||||||| ..|.|     ||.|        |:|||  .|| ::||||..|:...|..
Mosquito  1113 NQTSSNFSSRDSYDSIFESMP-----PPPPHYHTHQHQQKSPYSSSDP-KQHFPLPPRKSSNESP 1171

  Fly  1165 EVRTFLCTDQRCASIFEPRPSSVLTQQLSTGSMSTPSGYTNGTPRIPGAAPVGPVPLPHPSAPLS 1229
            .   |||||:|||:|||||||..     |.|::|...|...|.    |||.|        :..||
Mosquito  1172 R---FLCTDKRCAAIFEPRPSVG-----SIGTVSAGGGVGGGI----GAASV--------TGRLS 1216

  Fly  1230 SC--GFSSGSEFEPPSPRRAASASPKHTFTFRIVMKKVDSSPEALCPERHRSRIID----RYRRR 1288
            ||  ..||||||||||||||||||||||||||||:|||||||:|:||...|.::.:    |::||
Mosquito  1217 SCYLDTSSGSEFEPPSPRRAASASPKHTFTFRIVLKKVDSSPDAICPSAERRQLREKAESRHKRR 1281

  Fly  1289 DSRRKRIHDAGKSF 1302
            |||||::.:.||||
Mosquito  1282 DSRRKKLLEIGKSF 1295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gprs	NP_725599.2	BTB_POZ_BTBD19	26..184	CDD:349603	133/157 (85%)
		BACK_GPRS_like	189..268	CDD:350582	76/78 (97%)
gprs	XP_061514418.1	None