DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5065 and FAR2

DIOPT Version :9

Sequence 1:	NP_001163168.1	Gene:	CG5065 / 36860	FlyBaseID:	FBgn0034145	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_011519049.1	Gene:	FAR2 / 55711	HGNCID:	25531	Length:	535	Species:	Homo sapiens

Alignment Length:	490	Identity:	194/490 - (39%)
Similarity:	298/490 - (60%)	Gaps:	0/490 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 IAQFYAGRSVFITGGTGFMGKVLVEKLLRSCPEIRNIYLLIRPKRGQEVSARLTELLNAPLFESL 183
            ||.||.|:|:.|||.|||:||||:|||.|:.|:::.||:|:|||.||.:..|:.::|::.|||.:
Human    24 IAAFYGGKSILITGATGFLGKVLMEKLFRTSPDLKVIYILVRPKAGQTLQQRVFQILDSKLFEKV 88

  Fly   184 RQEKPKELSKVIPISGDITSEELGISEKDQNLLCRNVSVVFHSAATVKFDEKLKLSVTINMLGTK 248
            ::..|....|:..|..|:...:..||::|...|....:::||.||||:||:.|:.:|.:|:..|:
Human    89 KEVCPNVHEKIRAIYADLNQNDFAISKEDMQELLSCTNIIFHCAATVRFDDTLRHAVQLNVTATR 153

  Fly   249 RLVELCHRMLSLDALIHVSTAYCNCDRTDVSEVIYAPPYNPDDIISLINWLPEDILDQLTPRLIG 313
            :|:.:..:|..|:|.||:||||.||:...:.||||..|..|..||..:.||.:.|:|::||:||.
Human   154 QLLLMASQMPKLEAFIHISTAYSNCNLKHIDEVIYPCPVEPKKIIDSLEWLDDAIIDEITPKLIR 218

  Fly   314 KRPNTYTFTKALAEHMLLKEAGNLPVAIVRPSIVTASLNEPFAGWVDNFNGPTGLVSALAKGMFR 378
            ..||.||:||||.|.::.:|:.||.:||:|||||.|:..|||.|||||.|||.|::.|..||..|
Human   219 DWPNIYTYTKALGEMVVQQESRNLNIAIIRPSIVGATWQEPFPGWVDNINGPNGIIIATGKGFLR 283

  Fly   379 TMMCEKNYVADMVPVDIVINLMIAAAWRTATRKSNNLLIYNCCTGQRNPIIWSEFVKHAMTSVRK 443
            .:......|||::|||.|:|||:|..|.||..:..:.|:|:..:|..||..|.:.....:.:..|
Human   284 AIKATPMAVADVIPVDTVVNLMLAVGWYTAVHRPKSTLVYHITSGNMNPCNWHKMGVQVLATFEK 348

  Fly   444 HPLEGCLWYPTGDLRMNRPMNTLNCIAKHFLPAYILDGVARIMGKKPFVVNVQNKIAKAVECLEY 508
            .|.|.....|..:...|...:.......|..||.|.|...|:.|:||.:..:.|::.:.|..|||
Human   349 IPFERPFRRPNANFTSNSFTSQYWNAVSHRAPAIIYDCYLRLTGRKPRMTKLMNRLLRTVSMLEY 413

  Fly   509 FATRQWRFKDDNVHALLHTLSPKDREIFVFDVRHINWDKYVERYVLGFREFLFKQRPESLPASRK 573
            |..|.|.:...|...|:..|||:|:.:|.||||.:||.:|:|.||||.:::|.|:....:|.:::
Human   414 FINRSWEWSTYNTEMLMSELSPEDQRVFNFDVRQLNWLEYIENYVLGVKKYLLKEDMAGIPKAKQ 478

  Fly   574 RMLRLYYLHQLTKLVAVLLTWRFLMSRSKRLNDLW 608
            |:.||..:|.|......|:.||.|::||:...::|
Human   479 RLKRLRNIHYLFNTALFLIAWRLLIARSQMARNVW 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5065	NP_001163168.1	FAR-N_SDR_e	126..445	CDD:187547	134/318 (42%)
CG5065	NP_001163168.1	Sterile	472..562	CDD:281068	37/89 (42%)
FAR2	XP_011519049.1	PLN02996	22..467	CDD:215538	180/442 (41%)
		FAR-N_SDR_e	31..335	CDD:187547	132/303 (44%)
		Sterile	377..467	CDD:281068	37/89 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157502
Domainoid	1	1.000	286	1.000	Domainoid score	I1606
eggNOG	1	0.900	-	-		E1_COG3320
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H69247
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1684
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		otm40264
orthoMCL	1	0.900	-	-		OOG6_100550
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.660