DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5065 and Far2

DIOPT Version :9

Sequence 1:	NP_001163168.1	Gene:	CG5065 / 36860	FlyBaseID:	FBgn0034145	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_006237759.1	Gene:	Far2 / 500368	RGDID:	1565966	Length:	515	Species:	Rattus norvegicus

Alignment Length:	494	Identity:	207/494 - (41%)
Similarity:	309/494 - (62%)	Gaps:	8/494 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 IAQFYAGRSVFITGGTGFMGKVLVEKLLRSCPEIRNIYLLIRPKRGQEVSARLTELLNAPLFESL 183
            ||.||:.:|:.|||.|||:||||:|||.|:.|.::.||:|:|||.||.:..|:.::||:.|||.:
  Rat     4 IAAFYSNKSILITGATGFLGKVLMEKLFRTSPHLKVIYILVRPKSGQTLQERVFQILNSKLFERV 68

  Fly   184 RQEKPKELSKVIPISGDITSEELGISEKDQNLLCRNVSVVFHSAATVKFDEKLKLSVTINMLGTK 248
            ::..|....|:.|||.|:...:..||::|...|....::|||.||||:||..|:.:|.:|:..|:
  Rat    69 KEVCPNVHEKIRPISADLNQRDFAISKEDMQELLSCTNIVFHCAATVRFDAHLREAVQLNVTATQ 133

  Fly   249 RLVELCHRMLSLDALIHVSTAYCNCDRTDVSEVIYAPPYNPDDIISLINWLPEDILDQLTPRLIG 313
            :|:.:...|..|:|.||:|||:.||:.:.:.||||..|..|..||..:.||.:.|::::||:|||
  Rat   134 QLLLMASEMPKLEAFIHISTAFSNCNLSHIDEVIYPCPVEPRKIIDSMEWLDDSIIEEITPKLIG 198

  Fly   314 KRPNTYTFTKALAEHMLLKEAGNLPVAIVRPSIVTASLNEPFAGWVDNFNGPTGLVSALAKGMFR 378
            .||||||:||||.|.::.:|:|||.|||||||||.|:..|||.|||||.|||:||:.|..||..|
  Rat   199 DRPNTYTYTKALGEVVVQQESGNLNVAIVRPSIVGATWQEPFPGWVDNLNGPSGLIIATGKGFLR 263

  Fly   379 TMMCEKNYVADMVPVDIVINLMIAAAWRTATRKSNNLLIYNCCTGQRNPIIWSEFVKHAMTSVRK 443
            ::......|||::|||.|:||.||..|.||..:..:.|||:..:|..||..|.|.....:.:|.|
  Rat   264 SIKATPMAVADLIPVDTVVNLTIAVGWYTAVHRPKSTLIYHSTSGNLNPCNWYEMGLQVLATVEK 328

  Fly   444 HPLEGCLWYPTGDLRMN----RPMNTLNCIAKHFLPAYILDGVARIMGKKPFVVNVQNKIAKAVE 504
            .|.|.....|..|...|    :..||::    |:.||.|.|...|:.|:||.::.:.|::.|.:.
  Rat   329 IPFESAFRRPNADFTTNNFTTQYWNTVS----HWAPAIIYDFYLRLTGRKPRMLKLMNRLLKTIS 389

  Fly   505 CLEYFATRQWRFKDDNVHALLHTLSPKDREIFVFDVRHINWDKYVERYVLGFREFLFKQRPESLP 569
            .||||....|.:..:|...||..|||:|:.:|.||||.:||.:|:|.||||.:::|.|:....:|
  Rat   390 MLEYFINHSWEWSTNNTEMLLSELSPEDQRVFNFDVRQLNWLEYIENYVLGVKKYLLKEDLAGIP 454

  Fly   570 ASRKRMLRLYYLHQLTKLVAVLLTWRFLMSRSKRLNDLW 608
            .:::.:.||..:|.|......|:.||.|::||:...::|
  Rat   455 KAKQHLKRLRNIHYLFNTALFLIIWRLLIARSQMARNIW 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5065	NP_001163168.1	FAR-N_SDR_e	126..445	CDD:187547	146/318 (46%)
CG5065	NP_001163168.1	Sterile	472..562	CDD:281068	37/89 (42%)
Far2	XP_006237759.1	FAR-N_SDR_e	11..318	CDD:187547	143/306 (47%)
Far2	XP_006237759.1	Sterile	357..447	CDD:397244	37/89 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351502
Domainoid	1	1.000	288	1.000	Domainoid score	I1509
eggNOG	1	0.900	-	-		E1_COG3320
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H69247
Inparanoid	1	1.050	437	1.000	Inparanoid score	I1632
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		otm44391
orthoMCL	1	0.900	-	-		OOG6_100550
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X145
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.660