DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5065 and CG8303

DIOPT Version :9

Sequence 1:	NP_001163168.1	Gene:	CG5065 / 36860	FlyBaseID:	FBgn0034145	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001286495.1	Gene:	CG8303 / 36858	FlyBaseID:	FBgn0034143	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	571	Identity:	182/571 - (31%)
Similarity:	278/571 - (48%)	Gaps:	82/571 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 GGPTSSASLSIAAGVASSTALPLPPSS-----------NGLQMPYERFRADDTSYVPIAQFYAGR 126
            ||.|||                 ||.:           ||.|:         ::.:.|.:|:|.:
  Fly     8 GGTTSS-----------------PPENNNSIGNGKHRVNGHQL---------STSLTIPEFFAHK 46

  Fly   127 SVFITGGTGFMGKVLVEKLLRSCPEIRNIYLLIRPKRGQEVSARLTELLNAPLFESLRQEKPKEL 191
            ::|:||||||:|.||:|.||.:.|:|..||:|:|.||..:.:.|:..||..|:||...:   |.|
  Fly    47 NIFVTGGTGFLGTVLIEALLDTHPDIGTIYVLVRGKRKFDPNERIRRLLQKPIFEKYSE---KTL 108

  Fly   192 SKVIPISGDITSEELGISEKDQNLLCRNVSVVFHSAATVKFDEKLKLSVTINMLGTKRLVELCHR 256
            |||:|:.|:::....|...:....|...|:|::|||||:||...|:.::..|:.||.|.:||..:
  Fly   109 SKVVPVVGELSEPNFGFGPELLQELIDRVNVIYHSAATIKFSSPLRTAIRTNLTGTMRTIELAKQ 173

  Fly   257 MLSLDALIHVSTAYCNC-DRTDVSEVIYAPPYNPDDIISLIN----WLPEDILDQLTPRLIGKRP 316
            :..|.|.|:.|||:||. :|..::|.:|...::|.:::.:..    |  ||..||.....|...|
  Fly   174 LKQLAAYIYCSTAFCNSNNRGLIAEEVYKSQFDPYEMMKMAEDDSAW--EDFTDQKCKGYIRDHP 236

  Fly   317 NTYTFTKALAEHMLLKEAGNLPVAIVRPSIVTASLNEPFAGWVDNFN-GPTGLVSALAKGMFRTM 380
            |||||||.|:|::|:.|...||.||||||||..:|..|..|||.|.| |..|.::...||:||||
  Fly   237 NTYTFTKNLSENLLMAEMSGLPAAIVRPSIVYGTLEHPMKGWVGNANSGHLGFLAGFVKGIFRTM 301

  Fly   381 MCEKNYVADMVPVDIVINLMIAAAWRTATRKSNNLLIYNCCTGQRNPIIWSEFVKHAMTSVRKHP 445
            ....|.|.|::|.|.|||..:...|...|||.....|.:|.:|:.||:..:||......||.:||
  Fly   302 CGNANAVIDIIPCDYVINSSLVMGWYVGTRKLEQPEIIHCTSGEVNPLNLAEFCTIINDSVERHP 366

  Fly   446 LEGCLWYPTGDLRMNRPMNTLNCIAKHFLPAYILDGVARIMGKKPFVVNVQNKIA--------KA 502
            ....:|.|...||.....| |.....|.|||.:.     |:.:|.|.:.:....|        |.
  Fly   367 PNSFVWKPVTKLRNGWRYN-LFFYLFHLLPAMVF-----IIPEKLFGIGMPQHTAYEYMRVFQKG 425

  Fly   503 VECLEYFATRQWRFKDDNVHALLHTLSPKDREIFVFDVRHINWDKYVERYVLGFREFLFKQRPES 567
            .:..:||..:.:|:...|...:...:...||..:.||....:|.::::|.::|.|.|.||:...:
  Fly   426 TKAFDYFLDKDFRYSLKNALRISALIPESDRRRYNFDASQCDWSEFIDRCLIGIRRFYFKESAVT 490

  Fly   568 LPASRK--RMLRLYYLHQLTKLVAVL------------------LTWRFLM 598
            ....|.  ::..:.|......:.|||                  |.|.||:
  Fly   491 TDWHRNYWKVFNVLYYAGYVVIFAVLYFALTLTLGLQIGLTLAVLIWGFLV 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5065	NP_001163168.1	FAR-N_SDR_e	126..445	CDD:187547	128/324 (40%)
CG5065	NP_001163168.1	Sterile	472..562	CDD:281068	22/97 (23%)
CG8303	NP_001286495.1	FAR-N_SDR_e	46..366	CDD:187547	128/324 (40%)
CG8303	NP_001286495.1	Sterile	392..485	CDD:281068	22/97 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466829
Domainoid	1	1.000	159	1.000	Domainoid score	I1277
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I1437
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		mtm964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	8.000